Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis
BACKGROUND: This study evaluated the role of HA as a marker of liver fibrosis in patients with hepatitis C on haemodialysis. METHODS: This is a cross-sectional study in which 52 patients were divided into two groups: Group 1: patients with hepatitis C and end-stage renal disease (ESRD) undergoing haemodialysis (n = 23); and Group 2: patients with hepatitis C without ESRD (n = 29). Plasma levels of HA were associated with histological data of the samples obtained by liver biopsy and classified by METAVIR group scoring system. RESULTS: Higher plasma levels were significantly correlated to significant liver fibrosis (METAVIR > F2). In Group 1, the HA cutoff to discriminate significant fibrosis was 984.8 ng/mL, with accuracy, sensitivity and specificity of 80.8%, 83.0%, and 70.0%, respectively. In Group 2, the HA cutoff was 222.3 ng/mL, with accuracy, sensitivity and specificity of 74.5%, 70.0%, and 94.0%, respectively. CONCLUSION: HA was an accurate noninvasive marker in predicting significant fibrosis in patients with hepatitis C on haemodialysis.
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Brazilian Society of Infectious Diseases
2010
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oai:scielo:S1413-867020100004000042010-10-06Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysisÁvila,Renata Eliane deCarmo,Ricardo AndradeFarah,Kátia de PaulaTeixeira,Antônio LúcioCoimbra,Lucas VianaAntunes,Carlos MaurÃcio de FigueiredoLambertucci,José Roberto liver fibrosis hyaluronic acid end-stage renal disease haemodialysis hepatitis C BACKGROUND: This study evaluated the role of HA as a marker of liver fibrosis in patients with hepatitis C on haemodialysis. METHODS: This is a cross-sectional study in which 52 patients were divided into two groups: Group 1: patients with hepatitis C and end-stage renal disease (ESRD) undergoing haemodialysis (n = 23); and Group 2: patients with hepatitis C without ESRD (n = 29). Plasma levels of HA were associated with histological data of the samples obtained by liver biopsy and classified by METAVIR group scoring system. RESULTS: Higher plasma levels were significantly correlated to significant liver fibrosis (METAVIR > F2). In Group 1, the HA cutoff to discriminate significant fibrosis was 984.8 ng/mL, with accuracy, sensitivity and specificity of 80.8%, 83.0%, and 70.0%, respectively. In Group 2, the HA cutoff was 222.3 ng/mL, with accuracy, sensitivity and specificity of 74.5%, 70.0%, and 94.0%, respectively. CONCLUSION: HA was an accurate noninvasive marker in predicting significant fibrosis in patients with hepatitis C on haemodialysis.info:eu-repo/semantics/openAccessBrazilian Society of Infectious DiseasesBrazilian Journal of Infectious Diseases v.14 n.4 20102010-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400004en10.1590/S1413-86702010000400004 |
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Ávila,Renata Eliane de Carmo,Ricardo Andrade Farah,Kátia de Paula Teixeira,Antônio Lúcio Coimbra,Lucas Viana Antunes,Carlos MaurÃcio de Figueiredo Lambertucci,José Roberto |
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Ávila,Renata Eliane de Carmo,Ricardo Andrade Farah,Kátia de Paula Teixeira,Antônio Lúcio Coimbra,Lucas Viana Antunes,Carlos MaurÃcio de Figueiredo Lambertucci,José Roberto Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis |
author_facet |
Ávila,Renata Eliane de Carmo,Ricardo Andrade Farah,Kátia de Paula Teixeira,Antônio Lúcio Coimbra,Lucas Viana Antunes,Carlos MaurÃcio de Figueiredo Lambertucci,José Roberto |
author_sort |
Ávila,Renata Eliane de |
title |
Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis |
title_short |
Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis |
title_full |
Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis |
title_fullStr |
Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis |
title_full_unstemmed |
Hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis C on haemodialysis |
title_sort |
hyaluronic acid in the evaluation of liver fibrosis in patients with hepatitis c on haemodialysis |
description |
BACKGROUND: This study evaluated the role of HA as a marker of liver fibrosis in patients with hepatitis C on haemodialysis. METHODS: This is a cross-sectional study in which 52 patients were divided into two groups: Group 1: patients with hepatitis C and end-stage renal disease (ESRD) undergoing haemodialysis (n = 23); and Group 2: patients with hepatitis C without ESRD (n = 29). Plasma levels of HA were associated with histological data of the samples obtained by liver biopsy and classified by METAVIR group scoring system. RESULTS: Higher plasma levels were significantly correlated to significant liver fibrosis (METAVIR > F2). In Group 1, the HA cutoff to discriminate significant fibrosis was 984.8 ng/mL, with accuracy, sensitivity and specificity of 80.8%, 83.0%, and 70.0%, respectively. In Group 2, the HA cutoff was 222.3 ng/mL, with accuracy, sensitivity and specificity of 74.5%, 70.0%, and 94.0%, respectively. CONCLUSION: HA was an accurate noninvasive marker in predicting significant fibrosis in patients with hepatitis C on haemodialysis. |
publisher |
Brazilian Society of Infectious Diseases |
publishDate |
2010 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400004 |
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