Occult hepatitis B virus infection in immunocompromised patients
Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAg-negative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV positive patients was not a determining factor for occult HBV infection. In addition, no significant relationship between HBV-DNA and HCV co-infection in the HIV-positive patient group was found. A lack of significant associations was also observed between positivity for HBV-DNA and CD4 count, viral load and previous lamivudine treatment in these HIV-positive patients.
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Brazilian Society of Infectious Diseases
2008
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oai:scielo:S1413-867020080004000082008-11-13Occult hepatitis B virus infection in immunocompromised patientsJardim,Ruth Nogueira Cordeiro MoraesGonçales,Neiva Sellan LopesPereira,Josiane Silveira FelixFais,Viviane CristinaGonçales Junior,Fernando Lopes Occult HBV infection HBV-DNA anti-HBc alone hemodialysis HIV immunosupressed patients Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAg-negative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV positive patients was not a determining factor for occult HBV infection. In addition, no significant relationship between HBV-DNA and HCV co-infection in the HIV-positive patient group was found. A lack of significant associations was also observed between positivity for HBV-DNA and CD4 count, viral load and previous lamivudine treatment in these HIV-positive patients.info:eu-repo/semantics/openAccessBrazilian Society of Infectious DiseasesBrazilian Journal of Infectious Diseases v.12 n.4 20082008-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400008en10.1590/S1413-86702008000400008 |
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Jardim,Ruth Nogueira Cordeiro Moraes Gonçales,Neiva Sellan Lopes Pereira,Josiane Silveira Felix Fais,Viviane Cristina Gonçales Junior,Fernando Lopes |
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Jardim,Ruth Nogueira Cordeiro Moraes Gonçales,Neiva Sellan Lopes Pereira,Josiane Silveira Felix Fais,Viviane Cristina Gonçales Junior,Fernando Lopes Occult hepatitis B virus infection in immunocompromised patients |
author_facet |
Jardim,Ruth Nogueira Cordeiro Moraes Gonçales,Neiva Sellan Lopes Pereira,Josiane Silveira Felix Fais,Viviane Cristina Gonçales Junior,Fernando Lopes |
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Jardim,Ruth Nogueira Cordeiro Moraes |
title |
Occult hepatitis B virus infection in immunocompromised patients |
title_short |
Occult hepatitis B virus infection in immunocompromised patients |
title_full |
Occult hepatitis B virus infection in immunocompromised patients |
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Occult hepatitis B virus infection in immunocompromised patients |
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Occult hepatitis B virus infection in immunocompromised patients |
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occult hepatitis b virus infection in immunocompromised patients |
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Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAg-negative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV positive patients was not a determining factor for occult HBV infection. In addition, no significant relationship between HBV-DNA and HCV co-infection in the HIV-positive patient group was found. A lack of significant associations was also observed between positivity for HBV-DNA and CD4 count, viral load and previous lamivudine treatment in these HIV-positive patients. |
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Brazilian Society of Infectious Diseases |
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2008 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400008 |
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