Polypharmacy and potential drug-drug interactions in an HIV-infected elderly population
Abstract Objective: Comorbidities associated with the ageing of the HIV+ population may require chronic treatment. Our aim is to determine the degree of polypharmacy and the number of potential drug-drug interactions, as well as the relationship between both variables in a HIV-infected population over the age of 65. Methods: Descriptive transversal study targeting HIV+ patients aged ≥65, attended in a Spanish hospital in 2014. The prevalence of polypharmacy (≥5 drugs) and potential drug-drug interactions were assessed, and also risk factors associated with such. Results: 265 subjects aged ≥65 years were identified, 197 of whom were on antiretroviral treatment and had data about their electronic prescription. 93% were polymedicated. The patients whose antiretroviral treatment included a non -nucleoside reverse transcriptase inhibitor (NNRTI) demonstrated a fourfold probability of being polymedicated. 65% of the patients showed at least one potential drug-drug interaction and 6.6% a severe potential drug-drug interaction. The risk of interaction was significantly associated with the number of prescribed drugs (incidence rate ratio per prescribed drug, CI 95%: 1.18 (1.14;1.22; p<0.0001) and with the use of protease inhibitors (PI) (incidence rate ratio, CI 95%: 1.65 (1.28;2.11; p=0.0001)). Conclusion: Polypharmacy has a high prevalence and is more common in patients treated with NNRTI. The number of potential drug-drug interactions increase with the number of prescribed drugs and is higher in those patients on PI.
Autores principales: | Bastida,Carla, Grau,Ana, Márquez,Mónica, Tuset,Montse, De Lazzari,Elisa, Martínez,Esteban, Gatell,Josep María |
---|---|
Formato: | Digital revista |
Idioma: | English |
Publicado: |
Grupo Aula Médica
2017
|
Acceso en línea: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-63432017000500618 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Polypharmacy and potential drug-drug interactions in an HIV-infected elderly population
Publicado: (2017) -
Drug-drug interactions and adverse drug reactions in polypharmacy among older adults: an integrative review
por: Rodrigues,Maria Cristina Soares, et al.
Publicado: (2016) -
Pharmacogenetics, polypharmacy and drug interactions. The landscape of individualized medicine in dogs
por: Alfaro-Mora, Ramsés
Publicado: (2023) -
Gender differences, polypharmacy, and potential pharmacological interactions in the elderly
por: Venturini,Carina Duarte, et al.
Publicado: (2011) -
Drug-drug interactions and potentially inappropriate medications among elderly outpatients
por: Fatemeh,Atrianfar, et al.
Publicado: (2021)