Zinc therapy of neurological Wilsons disease in a woman with two foetus with agenesis of the corpus callosum
CLINICAL REPORT: A patient diagnosed Wilsons disease (WD) 22 years previously, successfully treated initially with zinc, developed neuropsychiatric disease after years of irregular therapy. Reassuming zinc therapy was successful. After a normal pregnancy, she had two therapeutic abortions for corpus callosum agenesis, and a missed abortion. We review the genetics, physiopathology, clinics and imagiologic response to zinc therapy, the problems of pregnancy in WD, advising to maintain therapy. A hypothetic cause for fetus brain anomaly would be hypocupremia due to zinc therapy, confronting with two other possibilities, one related to Wilsons disease in itself, other due to a congenital syndrome of agenesis of the corpus callosum, impossible to diagnose by our available diagnostic methods.
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Sociedade Portuguesa de Gastrenterologia
2010
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oai:scielo:S0872-817820100003000052010-12-28Zinc therapy of neurological Wilsons disease in a woman with two foetus with agenesis of the corpus callosumMurinello,AntónioTomé,TeresaGoulão,AugustoCohen,Álvaro Wilsons disease zinc corpus callosum agenesis hypocupremia CLINICAL REPORT: A patient diagnosed Wilsons disease (WD) 22 years previously, successfully treated initially with zinc, developed neuropsychiatric disease after years of irregular therapy. Reassuming zinc therapy was successful. After a normal pregnancy, she had two therapeutic abortions for corpus callosum agenesis, and a missed abortion. We review the genetics, physiopathology, clinics and imagiologic response to zinc therapy, the problems of pregnancy in WD, advising to maintain therapy. A hypothetic cause for fetus brain anomaly would be hypocupremia due to zinc therapy, confronting with two other possibilities, one related to Wilsons disease in itself, other due to a congenital syndrome of agenesis of the corpus callosum, impossible to diagnose by our available diagnostic methods.info:eu-repo/semantics/openAccessSociedade Portuguesa de GastrenterologiaJornal Português de Gastrenterologia v.17 n.3 20102010-05-01info:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782010000300005en |
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Murinello,António Tomé,Teresa Goulão,Augusto Cohen,Álvaro |
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Murinello,António Tomé,Teresa Goulão,Augusto Cohen,Álvaro Zinc therapy of neurological Wilsons disease in a woman with two foetus with agenesis of the corpus callosum |
| author_facet |
Murinello,António Tomé,Teresa Goulão,Augusto Cohen,Álvaro |
| author_sort |
Murinello,António |
| title |
Zinc therapy of neurological Wilsons disease in a woman with two foetus with agenesis of the corpus callosum |
| title_short |
Zinc therapy of neurological Wilsons disease in a woman with two foetus with agenesis of the corpus callosum |
| title_full |
Zinc therapy of neurological Wilsons disease in a woman with two foetus with agenesis of the corpus callosum |
| title_fullStr |
Zinc therapy of neurological Wilsons disease in a woman with two foetus with agenesis of the corpus callosum |
| title_full_unstemmed |
Zinc therapy of neurological Wilsons disease in a woman with two foetus with agenesis of the corpus callosum |
| title_sort |
zinc therapy of neurological wilsons disease in a woman with two foetus with agenesis of the corpus callosum |
| description |
CLINICAL REPORT: A patient diagnosed Wilsons disease (WD) 22 years previously, successfully treated initially with zinc, developed neuropsychiatric disease after years of irregular therapy. Reassuming zinc therapy was successful. After a normal pregnancy, she had two therapeutic abortions for corpus callosum agenesis, and a missed abortion. We review the genetics, physiopathology, clinics and imagiologic response to zinc therapy, the problems of pregnancy in WD, advising to maintain therapy. A hypothetic cause for fetus brain anomaly would be hypocupremia due to zinc therapy, confronting with two other possibilities, one related to Wilsons disease in itself, other due to a congenital syndrome of agenesis of the corpus callosum, impossible to diagnose by our available diagnostic methods. |
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Sociedade Portuguesa de Gastrenterologia |
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2010 |
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http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-81782010000300005 |
| work_keys_str_mv |
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1756002039883628544 |