Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma
This study aimed to assess the immunoexpression of cell proliferation markers (Ki-67 and Mcm-2) in oral tongue cancer, correlating it with patients' age and prognostic indicators. Sample was composed of 22 cases under 40 years and 22 over 50 years of age. Clinical staging and histological grade of malignancy were obtained. Cell proliferation was evaluated through labeling indices. Statistical analysis was performed (p<0.05 for statistical significance). Most young patients were stages III/IV (n=13/65 %) and most older patients were stages I/II (n=11/61.1 %) (p>0.05). Mean Ki-67-LI in young and older patients was 42.4 % and 44.15 %, respectively (p>0.05). Mean Mcm-2-LI was higher in older (63.6 %) than in young patients (55.75 %) (p<0.05). We found that young patients presented more aggressive lesions in comparison to older patients, however Mcm-2 expression was significantly higher in older than in young patients. SCC of tongue can be more aggressive in young patients, and this may not be related to cell proliferation. Our findings for Mcm-2 LI and Ki-67 LI suggests that Mcm-2 could be a more sensitive marker for cell proliferation.
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Universidad de La Frontera. Facultad de Medicina
2016
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oai:scielo:S0718-381X20160003000202017-02-15Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell CarcinomaPereira,Joabe dos SantosBarroso,Keila Martha AmorimNonaka,Cassiano Francisco WeegePinto,Leão Pereirade Souza,Lélia Batista oral cancer squamous cell carcinoma age groups ki-67 antigen biological markers prognosis This study aimed to assess the immunoexpression of cell proliferation markers (Ki-67 and Mcm-2) in oral tongue cancer, correlating it with patients' age and prognostic indicators. Sample was composed of 22 cases under 40 years and 22 over 50 years of age. Clinical staging and histological grade of malignancy were obtained. Cell proliferation was evaluated through labeling indices. Statistical analysis was performed (p<0.05 for statistical significance). Most young patients were stages III/IV (n=13/65 %) and most older patients were stages I/II (n=11/61.1 %) (p>0.05). Mean Ki-67-LI in young and older patients was 42.4 % and 44.15 %, respectively (p>0.05). Mean Mcm-2-LI was higher in older (63.6 %) than in young patients (55.75 %) (p<0.05). We found that young patients presented more aggressive lesions in comparison to older patients, however Mcm-2 expression was significantly higher in older than in young patients. SCC of tongue can be more aggressive in young patients, and this may not be related to cell proliferation. Our findings for Mcm-2 LI and Ki-67 LI suggests that Mcm-2 could be a more sensitive marker for cell proliferation.info:eu-repo/semantics/openAccessUniversidad de La Frontera. Facultad de MedicinaInternational journal of odontostomatology v.10 n.3 20162016-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2016000300020en10.4067/S0718-381X2016000300020 |
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Pereira,Joabe dos Santos Barroso,Keila Martha Amorim Nonaka,Cassiano Francisco Weege Pinto,Leão Pereira de Souza,Lélia Batista |
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Pereira,Joabe dos Santos Barroso,Keila Martha Amorim Nonaka,Cassiano Francisco Weege Pinto,Leão Pereira de Souza,Lélia Batista Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma |
author_facet |
Pereira,Joabe dos Santos Barroso,Keila Martha Amorim Nonaka,Cassiano Francisco Weege Pinto,Leão Pereira de Souza,Lélia Batista |
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Pereira,Joabe dos Santos |
title |
Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma |
title_short |
Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma |
title_full |
Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma |
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Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma |
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Immunoexpression of Cell Proliferation Markers in Oral Squamous Cell Carcinoma |
title_sort |
immunoexpression of cell proliferation markers in oral squamous cell carcinoma |
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This study aimed to assess the immunoexpression of cell proliferation markers (Ki-67 and Mcm-2) in oral tongue cancer, correlating it with patients' age and prognostic indicators. Sample was composed of 22 cases under 40 years and 22 over 50 years of age. Clinical staging and histological grade of malignancy were obtained. Cell proliferation was evaluated through labeling indices. Statistical analysis was performed (p<0.05 for statistical significance). Most young patients were stages III/IV (n=13/65 %) and most older patients were stages I/II (n=11/61.1 %) (p>0.05). Mean Ki-67-LI in young and older patients was 42.4 % and 44.15 %, respectively (p>0.05). Mean Mcm-2-LI was higher in older (63.6 %) than in young patients (55.75 %) (p<0.05). We found that young patients presented more aggressive lesions in comparison to older patients, however Mcm-2 expression was significantly higher in older than in young patients. SCC of tongue can be more aggressive in young patients, and this may not be related to cell proliferation. Our findings for Mcm-2 LI and Ki-67 LI suggests that Mcm-2 could be a more sensitive marker for cell proliferation. |
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Universidad de La Frontera. Facultad de Medicina |
publishDate |
2016 |
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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-381X2016000300020 |
work_keys_str_mv |
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