Casein-derived peptides as an alternative ingredient for low-phenylalanine diets

Casein-derived peptides as an alternative ingredient for low-phenylalanine diets

Abstract Introduction: casein-derived peptides can be liberated both in vivo via normal digestion of casein, as well as in vitro via enzymatic hydrolysis. These peptides were suggested to have biological activity. Objectives: the aim of this study was to describe the production and characterization of casein peptides and to explore the potential of these peptides as an option for low-phenylalanine diets. Methods: peptides were produced by tryptic hydrolysis of sodium caseinate and acid precipitation with HCl, followed by precipitation with ethanol or aggregation of CaCl2 or ZnSO4. Results: the amino acid analysis revealed a significant reduction in the amount of phenylalanine from the original protein. Conclusion: casein-derived peptides could be a future alternative of short chain peptides to low-phenylalanine formulations.

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Main Authors: Krüger,Claudia C H, Azevedo,Thaise D, Piltz,Marina T, Silva,Ágatha T, Cândido,Lys M B
Format: Digital revista
Language:English
Published: Grupo Arán 2019
Online Access:http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112019000300031
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spelling oai:scielo:S0212-161120190003000312021-03-11Casein-derived peptides as an alternative ingredient for low-phenylalanine dietsKrüger,Claudia C HAzevedo,Thaise DPiltz,Marina TSilva,Ágatha TCândido,Lys M B Casein Peptides Phenylalanine Phenylketonuria Abstract Introduction: casein-derived peptides can be liberated both in vivo via normal digestion of casein, as well as in vitro via enzymatic hydrolysis. These peptides were suggested to have biological activity. Objectives: the aim of this study was to describe the production and characterization of casein peptides and to explore the potential of these peptides as an option for low-phenylalanine diets. Methods: peptides were produced by tryptic hydrolysis of sodium caseinate and acid precipitation with HCl, followed by precipitation with ethanol or aggregation of CaCl2 or ZnSO4. Results: the amino acid analysis revealed a significant reduction in the amount of phenylalanine from the original protein. Conclusion: casein-derived peptides could be a future alternative of short chain peptides to low-phenylalanine formulations.Grupo AránNutrición Hospitalaria v.36 n.3 20192019-06-01journal articletext/htmlhttp://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112019000300031en
institution SCIELO
collection OJS
country España
countrycode ES
component Revista
access En linea
databasecode rev-scielo-es
tag revista
region Europa del Sur
libraryname SciELO
language English
format Digital
author Krüger,Claudia C H
Azevedo,Thaise D
Piltz,Marina T
Silva,Ágatha T
Cândido,Lys M B
spellingShingle Krüger,Claudia C H
Azevedo,Thaise D
Piltz,Marina T
Silva,Ágatha T
Cândido,Lys M B
Casein-derived peptides as an alternative ingredient for low-phenylalanine diets
author_facet Krüger,Claudia C H
Azevedo,Thaise D
Piltz,Marina T
Silva,Ágatha T
Cândido,Lys M B
author_sort Krüger,Claudia C H
title Casein-derived peptides as an alternative ingredient for low-phenylalanine diets
title_short Casein-derived peptides as an alternative ingredient for low-phenylalanine diets
title_full Casein-derived peptides as an alternative ingredient for low-phenylalanine diets
title_fullStr Casein-derived peptides as an alternative ingredient for low-phenylalanine diets
title_full_unstemmed Casein-derived peptides as an alternative ingredient for low-phenylalanine diets
title_sort casein-derived peptides as an alternative ingredient for low-phenylalanine diets
description Abstract Introduction: casein-derived peptides can be liberated both in vivo via normal digestion of casein, as well as in vitro via enzymatic hydrolysis. These peptides were suggested to have biological activity. Objectives: the aim of this study was to describe the production and characterization of casein peptides and to explore the potential of these peptides as an option for low-phenylalanine diets. Methods: peptides were produced by tryptic hydrolysis of sodium caseinate and acid precipitation with HCl, followed by precipitation with ethanol or aggregation of CaCl2 or ZnSO4. Results: the amino acid analysis revealed a significant reduction in the amount of phenylalanine from the original protein. Conclusion: casein-derived peptides could be a future alternative of short chain peptides to low-phenylalanine formulations.
publisher Grupo Arán
publishDate 2019
url http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112019000300031
work_keys_str_mv AT krugerclaudiach caseinderivedpeptidesasanalternativeingredientforlowphenylalaninediets
AT azevedothaised caseinderivedpeptidesasanalternativeingredientforlowphenylalaninediets
AT piltzmarinat caseinderivedpeptidesasanalternativeingredientforlowphenylalaninediets
AT silvaagathat caseinderivedpeptidesasanalternativeingredientforlowphenylalaninediets
AT candidolysmb caseinderivedpeptidesasanalternativeingredientforlowphenylalaninediets
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