Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer
Summary Objective: To evaluate the relation between serum total testosterone (TT) and prostate cancer (PCa) grade and the effect of race and demographic characteristics on such association. Method: We analyzed 695 patients undergoing radical prostatectomy (RP), of whom 423 had serum TT collected. Patients were classified as having hypogonadism or eugonadism based on two thresholds of testosterone: threshold 1 (300 ng/dL) and threshold 2 (250 ng/dL). We evaluated the relation between TT levels and a Gleason score (GS) ≥ 7 in RP specimens. Outcomes were evaluated using univariate and multivariate analyses, accounting for race and other demographic predictors. Results: Out of 423 patients, 37.8% had hypogonadism based on the threshold 1 and 23.9% based on the threshold 2. Patients with hypogonadism, in both thresholds, had a higher chance of GS ≥ 7 (OR 1.79, p=0.02 and OR 2.08, p=0.012, respectively). In the multivariate analysis, adjusted for age, TT, body mass index (BMI) and race, low TT (p=0.023) and age (p=0.002) were found to be independent risk factors for GS ≥ 7. Among Black individuals, low serum TT was a stronger predictor of high-grade disease compared to White men (p=0.02). Conclusion: Hypogonadism is independently associated to higher GS in localized PCa. The effect of this association is significantly more pronounced among Black men and could partly explain aggressive characteristics of PCa found in this race.
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Associação Médica Brasileira
2017
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000800704 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0104-42302017000800704 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0104-423020170008007042017-09-27Low serum testosterone is a predictor of high-grade disease in patients with prostate cancerAlbuquerque,George A. M. Lins deGuglielmetti,Giuliano B.Barbosa,João Arthur B. A.Pontes Jr.,JoséFazoli,Arnaldo J. C.Cordeiro,Maurício D.Coelho,Rafael F.Carvalho,Paulo Afonso deGallucci,Fábio P.Padovani,Guilherme P.Park,RubensCury,JoséNonemacher,HenriqueSrougi,MiguelNahas,William C. prostate cancer hypogonadism testosterone Summary Objective: To evaluate the relation between serum total testosterone (TT) and prostate cancer (PCa) grade and the effect of race and demographic characteristics on such association. Method: We analyzed 695 patients undergoing radical prostatectomy (RP), of whom 423 had serum TT collected. Patients were classified as having hypogonadism or eugonadism based on two thresholds of testosterone: threshold 1 (300 ng/dL) and threshold 2 (250 ng/dL). We evaluated the relation between TT levels and a Gleason score (GS) ≥ 7 in RP specimens. Outcomes were evaluated using univariate and multivariate analyses, accounting for race and other demographic predictors. Results: Out of 423 patients, 37.8% had hypogonadism based on the threshold 1 and 23.9% based on the threshold 2. Patients with hypogonadism, in both thresholds, had a higher chance of GS ≥ 7 (OR 1.79, p=0.02 and OR 2.08, p=0.012, respectively). In the multivariate analysis, adjusted for age, TT, body mass index (BMI) and race, low TT (p=0.023) and age (p=0.002) were found to be independent risk factors for GS ≥ 7. Among Black individuals, low serum TT was a stronger predictor of high-grade disease compared to White men (p=0.02). Conclusion: Hypogonadism is independently associated to higher GS in localized PCa. The effect of this association is significantly more pronounced among Black men and could partly explain aggressive characteristics of PCa found in this race.info:eu-repo/semantics/openAccessAssociação Médica BrasileiraRevista da Associação Médica Brasileira v.63 n.8 20172017-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000800704en10.1590/1806-9282.63.08.704 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Albuquerque,George A. M. Lins de Guglielmetti,Giuliano B. Barbosa,João Arthur B. A. Pontes Jr.,José Fazoli,Arnaldo J. C. Cordeiro,Maurício D. Coelho,Rafael F. Carvalho,Paulo Afonso de Gallucci,Fábio P. Padovani,Guilherme P. Park,Rubens Cury,José Nonemacher,Henrique Srougi,Miguel Nahas,William C. |
spellingShingle |
Albuquerque,George A. M. Lins de Guglielmetti,Giuliano B. Barbosa,João Arthur B. A. Pontes Jr.,José Fazoli,Arnaldo J. C. Cordeiro,Maurício D. Coelho,Rafael F. Carvalho,Paulo Afonso de Gallucci,Fábio P. Padovani,Guilherme P. Park,Rubens Cury,José Nonemacher,Henrique Srougi,Miguel Nahas,William C. Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
author_facet |
Albuquerque,George A. M. Lins de Guglielmetti,Giuliano B. Barbosa,João Arthur B. A. Pontes Jr.,José Fazoli,Arnaldo J. C. Cordeiro,Maurício D. Coelho,Rafael F. Carvalho,Paulo Afonso de Gallucci,Fábio P. Padovani,Guilherme P. Park,Rubens Cury,José Nonemacher,Henrique Srougi,Miguel Nahas,William C. |
author_sort |
Albuquerque,George A. M. Lins de |
title |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
title_short |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
title_full |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
title_fullStr |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
title_full_unstemmed |
Low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
title_sort |
low serum testosterone is a predictor of high-grade disease in patients with prostate cancer |
description |
Summary Objective: To evaluate the relation between serum total testosterone (TT) and prostate cancer (PCa) grade and the effect of race and demographic characteristics on such association. Method: We analyzed 695 patients undergoing radical prostatectomy (RP), of whom 423 had serum TT collected. Patients were classified as having hypogonadism or eugonadism based on two thresholds of testosterone: threshold 1 (300 ng/dL) and threshold 2 (250 ng/dL). We evaluated the relation between TT levels and a Gleason score (GS) ≥ 7 in RP specimens. Outcomes were evaluated using univariate and multivariate analyses, accounting for race and other demographic predictors. Results: Out of 423 patients, 37.8% had hypogonadism based on the threshold 1 and 23.9% based on the threshold 2. Patients with hypogonadism, in both thresholds, had a higher chance of GS ≥ 7 (OR 1.79, p=0.02 and OR 2.08, p=0.012, respectively). In the multivariate analysis, adjusted for age, TT, body mass index (BMI) and race, low TT (p=0.023) and age (p=0.002) were found to be independent risk factors for GS ≥ 7. Among Black individuals, low serum TT was a stronger predictor of high-grade disease compared to White men (p=0.02). Conclusion: Hypogonadism is independently associated to higher GS in localized PCa. The effect of this association is significantly more pronounced among Black men and could partly explain aggressive characteristics of PCa found in this race. |
publisher |
Associação Médica Brasileira |
publishDate |
2017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000800704 |
work_keys_str_mv |
AT albuquerquegeorgeamlinsde lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT guglielmettigiulianob lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT barbosajoaoarthurba lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT pontesjrjose lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT fazoliarnaldojc lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT cordeiromauriciod lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT coelhorafaelf lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT carvalhopauloafonsode lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT galluccifabiop lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT padovaniguilhermep lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT parkrubens lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT curyjose lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT nonemacherhenrique lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT srougimiguel lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer AT nahaswilliamc lowserumtestosteroneisapredictorofhighgradediseaseinpatientswithprostatecancer |
_version_ |
1756409974640082944 |