Smoking and its association with cryptorchidism in Down syndrome
Summary Introduction: Cryptorchidism is a common and prevalent condition in patients with Down syndrome. Environmental factors, such as smoking, can be associated with malformations during fetal development. The study of the prevalence of cryptorchidism and its association with parental tobacco use in Down syndrome can contribute to alert health care professionals, patients and family members regarding the prevention of the harms caused by cryptorchidism and its possible predisposing factors. Objective: To evaluate the prevalence of cryptorchidism in Down syndrome and its association with maternal and paternal smoking. Method: Forty (40) patients of a public clinic specialized in Down syndrome were evaluated, using a semi-structured questionnaire for evaluation of antecedents and sociodemographic characteristics, as well as physical and complementary examinations. Results: Cryptorchidism was observed in 27.5% of the patients (95CI 15.98-42.96). Of these, 55% (5/9) were the children of mothers who smoked during pregnancy, and 19.35% (6/31) were the children of mothers who did not smoke during pregnancy (OR = 5.26 [95CI 1.06-25.41]; p=0.032). Similarly, paternal smoking was also observed in greater frequency among the parents of cryptorchid patients compared with subjects with descended testis, 63.36% (7/11) and 31.03% (9/29), respectively (OR = 3.89 [95CI 0.91-16.73]; p=0.060). Conclusion: The prevalence of cryptorchidism is high in patients with Down syndrome. We can show a strong association between smoking parents and the occurrence of cryptorchidism, especially when it comes to maternal smoking.
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Associação Médica Brasileira
2017
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oai:scielo:S0104-423020170008006932017-09-27Smoking and its association with cryptorchidism in Down syndromeDuarte,Adrianne Maria Berno de RezendeBessa Júnior,José deMrad,Flávia Cristina de CarvalhoTibiriçá,Sandra Helena CerratoCamargo,Maíra Lorenzo de SáVieira,Augusto Alves PintoAraujo,Frederico Cantarino CordeiroFigueiredo,André Avarese deBastos-Netto,José Murillo de smoking Down syndrome cryptorchidism urologic diseases Summary Introduction: Cryptorchidism is a common and prevalent condition in patients with Down syndrome. Environmental factors, such as smoking, can be associated with malformations during fetal development. The study of the prevalence of cryptorchidism and its association with parental tobacco use in Down syndrome can contribute to alert health care professionals, patients and family members regarding the prevention of the harms caused by cryptorchidism and its possible predisposing factors. Objective: To evaluate the prevalence of cryptorchidism in Down syndrome and its association with maternal and paternal smoking. Method: Forty (40) patients of a public clinic specialized in Down syndrome were evaluated, using a semi-structured questionnaire for evaluation of antecedents and sociodemographic characteristics, as well as physical and complementary examinations. Results: Cryptorchidism was observed in 27.5% of the patients (95CI 15.98-42.96). Of these, 55% (5/9) were the children of mothers who smoked during pregnancy, and 19.35% (6/31) were the children of mothers who did not smoke during pregnancy (OR = 5.26 [95CI 1.06-25.41]; p=0.032). Similarly, paternal smoking was also observed in greater frequency among the parents of cryptorchid patients compared with subjects with descended testis, 63.36% (7/11) and 31.03% (9/29), respectively (OR = 3.89 [95CI 0.91-16.73]; p=0.060). Conclusion: The prevalence of cryptorchidism is high in patients with Down syndrome. We can show a strong association between smoking parents and the occurrence of cryptorchidism, especially when it comes to maternal smoking.info:eu-repo/semantics/openAccessAssociação Médica BrasileiraRevista da Associação Médica Brasileira v.63 n.8 20172017-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000800693en10.1590/1806-9282.63.08.693 |
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Duarte,Adrianne Maria Berno de Rezende Bessa Júnior,José de Mrad,Flávia Cristina de Carvalho Tibiriçá,Sandra Helena Cerrato Camargo,Maíra Lorenzo de Sá Vieira,Augusto Alves Pinto Araujo,Frederico Cantarino Cordeiro Figueiredo,André Avarese de Bastos-Netto,José Murillo de |
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Duarte,Adrianne Maria Berno de Rezende Bessa Júnior,José de Mrad,Flávia Cristina de Carvalho Tibiriçá,Sandra Helena Cerrato Camargo,Maíra Lorenzo de Sá Vieira,Augusto Alves Pinto Araujo,Frederico Cantarino Cordeiro Figueiredo,André Avarese de Bastos-Netto,José Murillo de Smoking and its association with cryptorchidism in Down syndrome |
author_facet |
Duarte,Adrianne Maria Berno de Rezende Bessa Júnior,José de Mrad,Flávia Cristina de Carvalho Tibiriçá,Sandra Helena Cerrato Camargo,Maíra Lorenzo de Sá Vieira,Augusto Alves Pinto Araujo,Frederico Cantarino Cordeiro Figueiredo,André Avarese de Bastos-Netto,José Murillo de |
author_sort |
Duarte,Adrianne Maria Berno de Rezende |
title |
Smoking and its association with cryptorchidism in Down syndrome |
title_short |
Smoking and its association with cryptorchidism in Down syndrome |
title_full |
Smoking and its association with cryptorchidism in Down syndrome |
title_fullStr |
Smoking and its association with cryptorchidism in Down syndrome |
title_full_unstemmed |
Smoking and its association with cryptorchidism in Down syndrome |
title_sort |
smoking and its association with cryptorchidism in down syndrome |
description |
Summary Introduction: Cryptorchidism is a common and prevalent condition in patients with Down syndrome. Environmental factors, such as smoking, can be associated with malformations during fetal development. The study of the prevalence of cryptorchidism and its association with parental tobacco use in Down syndrome can contribute to alert health care professionals, patients and family members regarding the prevention of the harms caused by cryptorchidism and its possible predisposing factors. Objective: To evaluate the prevalence of cryptorchidism in Down syndrome and its association with maternal and paternal smoking. Method: Forty (40) patients of a public clinic specialized in Down syndrome were evaluated, using a semi-structured questionnaire for evaluation of antecedents and sociodemographic characteristics, as well as physical and complementary examinations. Results: Cryptorchidism was observed in 27.5% of the patients (95CI 15.98-42.96). Of these, 55% (5/9) were the children of mothers who smoked during pregnancy, and 19.35% (6/31) were the children of mothers who did not smoke during pregnancy (OR = 5.26 [95CI 1.06-25.41]; p=0.032). Similarly, paternal smoking was also observed in greater frequency among the parents of cryptorchid patients compared with subjects with descended testis, 63.36% (7/11) and 31.03% (9/29), respectively (OR = 3.89 [95CI 0.91-16.73]; p=0.060). Conclusion: The prevalence of cryptorchidism is high in patients with Down syndrome. We can show a strong association between smoking parents and the occurrence of cryptorchidism, especially when it comes to maternal smoking. |
publisher |
Associação Médica Brasileira |
publishDate |
2017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000800693 |
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