Trends of 9,416 multidrug-resistant Gram-negative bacteria
Summary Objective: a resistance of hospital-acquired bacteria to multiple antibiotics is a major concern worldwide. The objective of this study was to investigate multidrugresistant (MDR) bacteria, clinical specimens, origin of specimen and trends, and correlate these with bacterial sensitivity and consumption of antimicrobials. Methods: 9,416 bacteria of nosocomial origin were evaluated in a tertiary hospital, from 1999 to 2008. MDR was defined for Gram-negative bacteria (GNB) as resistance to two or more classes/groups of antibiotics. Results: GNB MDR increased by 3.7 times over the study period (p<0.001). Acinetobacter baumannii was the most prevalent (36.2%). Over the study period, there were significant 4.8-fold and 14.6-fold increases for A. baumannii and K. pneumoniae (p<0.001), respectively. Sixty-seven percent of isolates of MDR GNB were isolated in intensive care units. The resistance of A. baumannii to carbapenems increased from 7.4 to 57.5% during the study period and concomitant with an increased consumption. Conclusion: that decade showed prevalence of GNB and a gradual increase in MDR GNB. There was an increase in carbapenem resistance of 50.1% during the study.
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Associação Médica Brasileira
2015
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oai:scielo:S0104-423020150003002442015-07-27Trends of 9,416 multidrug-resistant Gram-negative bacteriaOliveira,Viviane Decicera ColomboRubio,Fernando GóngoraAlmeida,Margarete Teresa GottardoNogueira,Mara Corrêa LellesPignatari,Antonio Carlos Campos Gram-negative bacteria drug resistance microbial hospitals university Summary Objective: a resistance of hospital-acquired bacteria to multiple antibiotics is a major concern worldwide. The objective of this study was to investigate multidrugresistant (MDR) bacteria, clinical specimens, origin of specimen and trends, and correlate these with bacterial sensitivity and consumption of antimicrobials. Methods: 9,416 bacteria of nosocomial origin were evaluated in a tertiary hospital, from 1999 to 2008. MDR was defined for Gram-negative bacteria (GNB) as resistance to two or more classes/groups of antibiotics. Results: GNB MDR increased by 3.7 times over the study period (p<0.001). Acinetobacter baumannii was the most prevalent (36.2%). Over the study period, there were significant 4.8-fold and 14.6-fold increases for A. baumannii and K. pneumoniae (p<0.001), respectively. Sixty-seven percent of isolates of MDR GNB were isolated in intensive care units. The resistance of A. baumannii to carbapenems increased from 7.4 to 57.5% during the study period and concomitant with an increased consumption. Conclusion: that decade showed prevalence of GNB and a gradual increase in MDR GNB. There was an increase in carbapenem resistance of 50.1% during the study. info:eu-repo/semantics/openAccessAssociação Médica BrasileiraRevista da Associação Médica Brasileira v.61 n.3 20152015-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302015000300244en10.1590/1806-9282.61.03.244 |
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Oliveira,Viviane Decicera Colombo Rubio,Fernando Góngora Almeida,Margarete Teresa Gottardo Nogueira,Mara Corrêa Lelles Pignatari,Antonio Carlos Campos |
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Oliveira,Viviane Decicera Colombo Rubio,Fernando Góngora Almeida,Margarete Teresa Gottardo Nogueira,Mara Corrêa Lelles Pignatari,Antonio Carlos Campos Trends of 9,416 multidrug-resistant Gram-negative bacteria |
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Oliveira,Viviane Decicera Colombo Rubio,Fernando Góngora Almeida,Margarete Teresa Gottardo Nogueira,Mara Corrêa Lelles Pignatari,Antonio Carlos Campos |
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Oliveira,Viviane Decicera Colombo |
title |
Trends of 9,416 multidrug-resistant Gram-negative bacteria |
title_short |
Trends of 9,416 multidrug-resistant Gram-negative bacteria |
title_full |
Trends of 9,416 multidrug-resistant Gram-negative bacteria |
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Trends of 9,416 multidrug-resistant Gram-negative bacteria |
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Trends of 9,416 multidrug-resistant Gram-negative bacteria |
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trends of 9,416 multidrug-resistant gram-negative bacteria |
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Summary Objective: a resistance of hospital-acquired bacteria to multiple antibiotics is a major concern worldwide. The objective of this study was to investigate multidrugresistant (MDR) bacteria, clinical specimens, origin of specimen and trends, and correlate these with bacterial sensitivity and consumption of antimicrobials. Methods: 9,416 bacteria of nosocomial origin were evaluated in a tertiary hospital, from 1999 to 2008. MDR was defined for Gram-negative bacteria (GNB) as resistance to two or more classes/groups of antibiotics. Results: GNB MDR increased by 3.7 times over the study period (p<0.001). Acinetobacter baumannii was the most prevalent (36.2%). Over the study period, there were significant 4.8-fold and 14.6-fold increases for A. baumannii and K. pneumoniae (p<0.001), respectively. Sixty-seven percent of isolates of MDR GNB were isolated in intensive care units. The resistance of A. baumannii to carbapenems increased from 7.4 to 57.5% during the study period and concomitant with an increased consumption. Conclusion: that decade showed prevalence of GNB and a gradual increase in MDR GNB. There was an increase in carbapenem resistance of 50.1% during the study. |
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Associação Médica Brasileira |
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2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302015000300244 |
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