Metabolic acid-base status in critically ill patients: is standard base excess correlated with serum lactate level?
BACKGROUND AND OBJECTIVES: To correlate standard base excess (SBE) with serum lactate level and demonstrate the independent prognostic significance of each one. METHODS: In a retrospective study, we retrieved data from 333 patients of our prospectively collected database of 7-bed medical intensive care unit of a 1800-bed university hospital. RESULTS: The results have shown a poor correlation between SBE and lactate, r = - 0.358, p < 0.001, and an independent prognostic significance of each one when analyzed concomitantly, odds ratio (95% Confidence interval) = 0.996 (0.992 - 0.999) to standard base excess and 1.000 (1.000 - 1.002) to lactate at entrance; and odds ratio (95% Confidence interval ) = 0.990 (0.985 - 0.994) to standard base excess and 1.003 (1.001 - 1.005) to lactate after 24 hours. The accuracy of standard base excess was close to lactate to determine in-intensive care unit death. CONCLUSIONS: The lactic component of the metabolic acidosis is not the major determinant of standard base excess. Serum lactate and SBE are independent outcome predictors in critically ill patients.
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Associação de Medicina Intensiva Brasileira - AMIB
2006
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oai:scielo:S0103-507X20060001000052008-05-06Metabolic acid-base status in critically ill patients: is standard base excess correlated with serum lactate level?Noritomi,Danilo TeixeiraSanga,Ricardo ReisAmaral,André Carlos Kajdaksi-BallaPark,Marcelo Acid-base equilibrium acidosis critical illness lactic acid prognosis BACKGROUND AND OBJECTIVES: To correlate standard base excess (SBE) with serum lactate level and demonstrate the independent prognostic significance of each one. METHODS: In a retrospective study, we retrieved data from 333 patients of our prospectively collected database of 7-bed medical intensive care unit of a 1800-bed university hospital. RESULTS: The results have shown a poor correlation between SBE and lactate, r = - 0.358, p < 0.001, and an independent prognostic significance of each one when analyzed concomitantly, odds ratio (95% Confidence interval) = 0.996 (0.992 - 0.999) to standard base excess and 1.000 (1.000 - 1.002) to lactate at entrance; and odds ratio (95% Confidence interval ) = 0.990 (0.985 - 0.994) to standard base excess and 1.003 (1.001 - 1.005) to lactate after 24 hours. The accuracy of standard base excess was close to lactate to determine in-intensive care unit death. CONCLUSIONS: The lactic component of the metabolic acidosis is not the major determinant of standard base excess. Serum lactate and SBE are independent outcome predictors in critically ill patients.info:eu-repo/semantics/openAccessAssociação de Medicina Intensiva Brasileira - AMIBRevista Brasileira de Terapia Intensiva v.18 n.1 20062006-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2006000100005en10.1590/S0103-507X2006000100005 |
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Noritomi,Danilo Teixeira Sanga,Ricardo Reis Amaral,André Carlos Kajdaksi-Balla Park,Marcelo |
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Noritomi,Danilo Teixeira Sanga,Ricardo Reis Amaral,André Carlos Kajdaksi-Balla Park,Marcelo Metabolic acid-base status in critically ill patients: is standard base excess correlated with serum lactate level? |
author_facet |
Noritomi,Danilo Teixeira Sanga,Ricardo Reis Amaral,André Carlos Kajdaksi-Balla Park,Marcelo |
author_sort |
Noritomi,Danilo Teixeira |
title |
Metabolic acid-base status in critically ill patients: is standard base excess correlated with serum lactate level? |
title_short |
Metabolic acid-base status in critically ill patients: is standard base excess correlated with serum lactate level? |
title_full |
Metabolic acid-base status in critically ill patients: is standard base excess correlated with serum lactate level? |
title_fullStr |
Metabolic acid-base status in critically ill patients: is standard base excess correlated with serum lactate level? |
title_full_unstemmed |
Metabolic acid-base status in critically ill patients: is standard base excess correlated with serum lactate level? |
title_sort |
metabolic acid-base status in critically ill patients: is standard base excess correlated with serum lactate level? |
description |
BACKGROUND AND OBJECTIVES: To correlate standard base excess (SBE) with serum lactate level and demonstrate the independent prognostic significance of each one. METHODS: In a retrospective study, we retrieved data from 333 patients of our prospectively collected database of 7-bed medical intensive care unit of a 1800-bed university hospital. RESULTS: The results have shown a poor correlation between SBE and lactate, r = - 0.358, p < 0.001, and an independent prognostic significance of each one when analyzed concomitantly, odds ratio (95% Confidence interval) = 0.996 (0.992 - 0.999) to standard base excess and 1.000 (1.000 - 1.002) to lactate at entrance; and odds ratio (95% Confidence interval ) = 0.990 (0.985 - 0.994) to standard base excess and 1.003 (1.001 - 1.005) to lactate after 24 hours. The accuracy of standard base excess was close to lactate to determine in-intensive care unit death. CONCLUSIONS: The lactic component of the metabolic acidosis is not the major determinant of standard base excess. Serum lactate and SBE are independent outcome predictors in critically ill patients. |
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Associação de Medicina Intensiva Brasileira - AMIB |
publishDate |
2006 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2006000100005 |
work_keys_str_mv |
AT noritomidaniloteixeira metabolicacidbasestatusincriticallyillpatientsisstandardbaseexcesscorrelatedwithserumlactatelevel AT sangaricardoreis metabolicacidbasestatusincriticallyillpatientsisstandardbaseexcesscorrelatedwithserumlactatelevel AT amaralandrecarloskajdaksiballa metabolicacidbasestatusincriticallyillpatientsisstandardbaseexcesscorrelatedwithserumlactatelevel AT parkmarcelo metabolicacidbasestatusincriticallyillpatientsisstandardbaseexcesscorrelatedwithserumlactatelevel |
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1756403878587269120 |