Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems

Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems

Packed bed reactors can be used as an interesting alternative on the bioreduction of β-ketoesteres mediated by immobilized microorganisms. Here in, we report our results on the bioreduction of ethyl 3-oxohexanoate by immobilized Kluyveromyces marxianus cells and tert-butyl 3-oxobutanoate by immobilized Rhodotorula rubra cells under continuous flow conditions leading the desired β-hydroxy esters corresponding in high yields and enantiomeric excess.

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Main Authors: Lopes,Raquel O., Grimm,Simon, Ribeiro,Joyce B., Leal,Ivana C. R., Miranda,Leandro S. M., Souza,Rodrigo O. M. A. de
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2015
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000300550
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spelling oai:scielo:S0103-505320150003005502017-11-09Improving the Toolbox of Bioreductions by the Use of Continuous Flow SystemsLopes,Raquel O.Grimm,SimonRibeiro,Joyce B.Leal,Ivana C. R.Miranda,Leandro S. M.Souza,Rodrigo O. M. A. de whole cell bioreduction packed bed reactor continuous flow asymmetric reduction Packed bed reactors can be used as an interesting alternative on the bioreduction of β-ketoesteres mediated by immobilized microorganisms. Here in, we report our results on the bioreduction of ethyl 3-oxohexanoate by immobilized Kluyveromyces marxianus cells and tert-butyl 3-oxobutanoate by immobilized Rhodotorula rubra cells under continuous flow conditions leading the desired β-hydroxy esters corresponding in high yields and enantiomeric excess.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society v.26 n.3 20152015-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000300550en10.5935/0103-5053.20150009
institution SCIELO
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Lopes,Raquel O.
Grimm,Simon
Ribeiro,Joyce B.
Leal,Ivana C. R.
Miranda,Leandro S. M.
Souza,Rodrigo O. M. A. de
spellingShingle Lopes,Raquel O.
Grimm,Simon
Ribeiro,Joyce B.
Leal,Ivana C. R.
Miranda,Leandro S. M.
Souza,Rodrigo O. M. A. de
Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
author_facet Lopes,Raquel O.
Grimm,Simon
Ribeiro,Joyce B.
Leal,Ivana C. R.
Miranda,Leandro S. M.
Souza,Rodrigo O. M. A. de
author_sort Lopes,Raquel O.
title Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
title_short Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
title_full Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
title_fullStr Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
title_full_unstemmed Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
title_sort improving the toolbox of bioreductions by the use of continuous flow systems
description Packed bed reactors can be used as an interesting alternative on the bioreduction of β-ketoesteres mediated by immobilized microorganisms. Here in, we report our results on the bioreduction of ethyl 3-oxohexanoate by immobilized Kluyveromyces marxianus cells and tert-butyl 3-oxobutanoate by immobilized Rhodotorula rubra cells under continuous flow conditions leading the desired β-hydroxy esters corresponding in high yields and enantiomeric excess.
publisher Sociedade Brasileira de Química
publishDate 2015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000300550
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