Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation
The furanditerpene 6a,7b-dihydroxyvouacapan-17b-oic acid (ADV, 1), isolated from Pterodon polygalaeflorus Benth fruits, presents analgesic activity in current rodent experimental models. With the aim to gather data for biological studies it were obtained six new amide derivatives substituted in the furan ring with alkylamine groups, prepared by the Mannich reaction with preformed iminium salts. These derivatives were evaluated in a preliminary in vitro pharmacological test. Structures were determined by spectroscopic data of IR, ¹H and 13C NMR.
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Sociedade Brasileira de Química
2002
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oai:scielo:S0103-505320020006000162015-11-26Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparationBelinelo,Valdenir J.Reis,Genuína T.Stefani,Guglielmo M.Ferreira-Alves,Dalton L.Piló-Veloso,Dorila furanditerpenes vouacapanoids Pterodon polygalaeflorus analgesics Mannich bases The furanditerpene 6a,7b-dihydroxyvouacapan-17b-oic acid (ADV, 1), isolated from Pterodon polygalaeflorus Benth fruits, presents analgesic activity in current rodent experimental models. With the aim to gather data for biological studies it were obtained six new amide derivatives substituted in the furan ring with alkylamine groups, prepared by the Mannich reaction with preformed iminium salts. These derivatives were evaluated in a preliminary in vitro pharmacological test. Structures were determined by spectroscopic data of IR, ¹H and 13C NMR.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society v.13 n.6 20022002-11-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600016en10.1590/S0103-50532002000600016 |
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Belinelo,Valdenir J. Reis,Genuína T. Stefani,Guglielmo M. Ferreira-Alves,Dalton L. Piló-Veloso,Dorila |
| spellingShingle |
Belinelo,Valdenir J. Reis,Genuína T. Stefani,Guglielmo M. Ferreira-Alves,Dalton L. Piló-Veloso,Dorila Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation |
| author_facet |
Belinelo,Valdenir J. Reis,Genuína T. Stefani,Guglielmo M. Ferreira-Alves,Dalton L. Piló-Veloso,Dorila |
| author_sort |
Belinelo,Valdenir J. |
| title |
Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation |
| title_short |
Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation |
| title_full |
Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation |
| title_fullStr |
Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation |
| title_full_unstemmed |
Synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. Part IV: mannich base derivatives and its activities on the electrically stimulated Guinea-pig ileum preparation |
| title_sort |
synthesis of 6a,7b-dihydroxyvouacapan-17b-oic acid derivatives. part iv: mannich base derivatives and its activities on the electrically stimulated guinea-pig ileum preparation |
| description |
The furanditerpene 6a,7b-dihydroxyvouacapan-17b-oic acid (ADV, 1), isolated from Pterodon polygalaeflorus Benth fruits, presents analgesic activity in current rodent experimental models. With the aim to gather data for biological studies it were obtained six new amide derivatives substituted in the furan ring with alkylamine groups, prepared by the Mannich reaction with preformed iminium salts. These derivatives were evaluated in a preliminary in vitro pharmacological test. Structures were determined by spectroscopic data of IR, ¹H and 13C NMR. |
| publisher |
Sociedade Brasileira de Química |
| publishDate |
2002 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532002000600016 |
| work_keys_str_mv |
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| _version_ |
1756403172052566016 |