Short courses of mechanical ventilation with high-O2 levels in elderly rat lungs
PURPOSE: To evaluate the effects of mechanical ventilation (MV) of high-oxygen concentration in pulmonary dysfunction in adult and elderly rats. METHODS: Twenty-eight adult (A) and elderly (E), male rats were ventilated for 1 hour (G-AV1 and G-EV1) or for 3 hours (G-AV3 and G-EV3). A and E groups received a tidal volume of 7 mL/kg, a positive end-expiratory pressure of 5 cm H2O, respiratory rate of 70 cycles per minute, and an inspiratory fraction of oxygen of 1. We evaluated total protein content and malondialdehyde in bronchoalveolar lavages (BAL) and performed lung histomorphometrical analyses. RESULTS: In G-EV1 animals, total protein in BAL was higher (33.0±1.9 µg/mL) compared with G-AV1 (23.0±2.0 µg/mL). Upon 180 minutes of MV, malondialdehyde levels increased in elderly (G-EV3) compared with adult (G-AV3) groups. Malondialdehyde and total proteins in BAL after 3 hours of MV were higher in elderly group than in adults. In G-EV3 group we observed alveolar septa dilatation and significative increase in neutrofiles number in relation to adult group at 60 and 180 minutes on MV. CONCLUSION: A higher fraction of inspired oxygen in short courses of mechanical ventilation ameliorates the parameters studied in elderly lungs.
Main Authors: | Cavassani,Sâmia Santos, Junqueira,Virginia Berlanga Campos, Moraes,Juliana Britto, Luzo,Karen Kristina, Silva,Claudeny Matos Assis, Barros,Maciel, Marinho,Márcia, Simões,Ricardo Santos, Oliveira-Júnior,Itamar Souza |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2011
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000200006 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Pretreatment with pentoxifylline attenuates lung injury induced by intestinal ischemia/reperfusion in rats
by: Marqui,Carlos Eduardo, et al.
Published: (2011) -
Strategic ventilation reduces non-ventilated contralateral lung injury induced by one-lung ventilation in rabbits
by: Liu,H.J., et al.
Published: (2021) -
Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats
by: Leite,Camila Ferreira, et al.
Published: (2013) -
Effects of pentoxifylline on TNF-alpha and lung histopathology in HCL-induced lung injury
by: Oliveira-Júnior,Itamar Souza de, et al.
Published: (2008) -
Corticosteroids for the prevention of ventilator-induced lung injury?
by: Holanda,Marcelo Alcantara
Published: (2016)