Angiogenic activity of Calendula officinalis flowers L. in rats

Angiogenic activity of Calendula officinalis flowers L. in rats

Purpose: In this work, angiogenic activity of Calendula officinalis L. (Asteraceae) ethanolic extract and dichloromethane and hexanic fractions were evaluated, considering medicinal properties, especially healing activity, are attributed to this plant. Methods: Models using 36 rats and 90 embryonated eggs were used to evaluate healing and angiogenic activities of extracts and fractions of the plant, through the induction of skin wounds and the chorioallantoic membrane, respectively. The effect of vascular proliferation was also tested from the study to verify the intensity of expression of vascular endothelial growth factor (VEGF) in cutaneous wounds in rats. Results: The angiogenic activity of the extract and the fractions was evidenced in both experimental models. It was verified that this effect is not directly related to the expression of VEGF and it could be associated to other pro-angiogenic factors. Conclusion: The healing activity referred to C. officinalis is related, among other factors, to its positive effect on angiogenesis, characterized by the induction of neovascularization.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Parente,Leila Maria Leal, Andrade,Maria Auxiliadora, Brito,Luiz Augusto Batista, Moura,Veridiana Maria Brianezi Dignani de, Miguel,Marina Pacheco, Lino-Júnior,Ruy de Souza, Tresvenzol,Leonice Faustino Manrique, Paula,José Realino de, Paulo,Neusa Margarida
Format: Digital revista
Langue:English
Publié: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2011
Accès en ligne:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000100005
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
id oai:scielo:S0102-86502011000100005
record_format ojs
spelling oai:scielo:S0102-865020110001000052011-04-08Angiogenic activity of Calendula officinalis flowers L. in ratsParente,Leila Maria LealAndrade,Maria AuxiliadoraBrito,Luiz Augusto BatistaMoura,Veridiana Maria Brianezi Dignani deMiguel,Marina PachecoLino-Júnior,Ruy de SouzaTresvenzol,Leonice Faustino ManriquePaula,José Realino dePaulo,Neusa Margarida Calendula Wound Healing Neovascularization, Physiologic Plants, Medicinal Rats Purpose: In this work, angiogenic activity of Calendula officinalis L. (Asteraceae) ethanolic extract and dichloromethane and hexanic fractions were evaluated, considering medicinal properties, especially healing activity, are attributed to this plant. Methods: Models using 36 rats and 90 embryonated eggs were used to evaluate healing and angiogenic activities of extracts and fractions of the plant, through the induction of skin wounds and the chorioallantoic membrane, respectively. The effect of vascular proliferation was also tested from the study to verify the intensity of expression of vascular endothelial growth factor (VEGF) in cutaneous wounds in rats. Results: The angiogenic activity of the extract and the fractions was evidenced in both experimental models. It was verified that this effect is not directly related to the expression of VEGF and it could be associated to other pro-angiogenic factors. Conclusion: The healing activity referred to C. officinalis is related, among other factors, to its positive effect on angiogenesis, characterized by the induction of neovascularization.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.26 n.1 20112011-02-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000100005en10.1590/S0102-86502011000100005
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Parente,Leila Maria Leal
Andrade,Maria Auxiliadora
Brito,Luiz Augusto Batista
Moura,Veridiana Maria Brianezi Dignani de
Miguel,Marina Pacheco
Lino-Júnior,Ruy de Souza
Tresvenzol,Leonice Faustino Manrique
Paula,José Realino de
Paulo,Neusa Margarida
spellingShingle Parente,Leila Maria Leal
Andrade,Maria Auxiliadora
Brito,Luiz Augusto Batista
Moura,Veridiana Maria Brianezi Dignani de
Miguel,Marina Pacheco
Lino-Júnior,Ruy de Souza
Tresvenzol,Leonice Faustino Manrique
Paula,José Realino de
Paulo,Neusa Margarida
Angiogenic activity of Calendula officinalis flowers L. in rats
author_facet Parente,Leila Maria Leal
Andrade,Maria Auxiliadora
Brito,Luiz Augusto Batista
Moura,Veridiana Maria Brianezi Dignani de
Miguel,Marina Pacheco
Lino-Júnior,Ruy de Souza
Tresvenzol,Leonice Faustino Manrique
Paula,José Realino de
Paulo,Neusa Margarida
author_sort Parente,Leila Maria Leal
title Angiogenic activity of Calendula officinalis flowers L. in rats
title_short Angiogenic activity of Calendula officinalis flowers L. in rats
title_full Angiogenic activity of Calendula officinalis flowers L. in rats
title_fullStr Angiogenic activity of Calendula officinalis flowers L. in rats
title_full_unstemmed Angiogenic activity of Calendula officinalis flowers L. in rats
title_sort angiogenic activity of calendula officinalis flowers l. in rats
description Purpose: In this work, angiogenic activity of Calendula officinalis L. (Asteraceae) ethanolic extract and dichloromethane and hexanic fractions were evaluated, considering medicinal properties, especially healing activity, are attributed to this plant. Methods: Models using 36 rats and 90 embryonated eggs were used to evaluate healing and angiogenic activities of extracts and fractions of the plant, through the induction of skin wounds and the chorioallantoic membrane, respectively. The effect of vascular proliferation was also tested from the study to verify the intensity of expression of vascular endothelial growth factor (VEGF) in cutaneous wounds in rats. Results: The angiogenic activity of the extract and the fractions was evidenced in both experimental models. It was verified that this effect is not directly related to the expression of VEGF and it could be associated to other pro-angiogenic factors. Conclusion: The healing activity referred to C. officinalis is related, among other factors, to its positive effect on angiogenesis, characterized by the induction of neovascularization.
publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publishDate 2011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502011000100005
work_keys_str_mv AT parenteleilamarialeal angiogenicactivityofcalendulaofficinalisflowerslinrats
AT andrademariaauxiliadora angiogenicactivityofcalendulaofficinalisflowerslinrats
AT britoluizaugustobatista angiogenicactivityofcalendulaofficinalisflowerslinrats
AT mouraveridianamariabrianezidignanide angiogenicactivityofcalendulaofficinalisflowerslinrats
AT miguelmarinapacheco angiogenicactivityofcalendulaofficinalisflowerslinrats
AT linojuniorruydesouza angiogenicactivityofcalendulaofficinalisflowerslinrats
AT tresvenzolleonicefaustinomanrique angiogenicactivityofcalendulaofficinalisflowerslinrats
AT paulajoserealinode angiogenicactivityofcalendulaofficinalisflowerslinrats
AT pauloneusamargarida angiogenicactivityofcalendulaofficinalisflowerslinrats
_version_ 1756400879987064832

Documents similaires