Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats
PURPOSE: Comparison of the inflammatory reaction promoted by textured silicone implants and that caused by the implant bonded with e-ptfe. METHODS: One-hundred and fifty rats were divided into three equal groups (control, silicone, and bonded e-ptfe). These groups were subdivided into five groups, according to the second operation, i.e., 7,30,60,90 and 180 days. Histology of the peri-implant tissue was analyzed by morphometry with blood count (neutrophilos, lymphocytes, macrophages, fibroblasts and capillaries). RESULTS: Comparison of subgroups 7,30,60,90, 180 days: - neutrophils: silicone: > in subgroup 7 days; bonded e-ptfe: > in subgroups 7 and 30 days; - lymphocytes: silicone: > in subgroup 7 and 180 days; bonded e-ptfe: > in subgroup 180 days; - macrophages: silicone: > in subgroup 7 and 60 days; bonded e-ptfe: > in subgroup 7,30 and 60 days; - fibroblasts: silicone: > in subgroup 30 and 60 days;- vascular volume: silicone: in subgroup 7, 60 and 90 days; bonded e-ptfe: > in subgroup 7 days. Comparison of groups: neutrophils : 7 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe; - lymphocytes: - 7,30,90 and 180 days: in the control; macrophages: - 7,30 and 60 days: > in silicone & bonded e-ptfe; 180 days > in silicone; fibroblasts: - 7,30 and 90 days: > in silicone and bonded e-ptfe; 180 days: > in bonded e-ptfe; vascular volume 7,60,90 and 180 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe. CONCLUSIONS: The acute stage of the inflammatory response was more severe and irregular in the silicone implant; both the silicone implant and the silicone bonded with e-ptfe promoted chronic inflammatory reaction and weak foreign body inflammatory response. These reactions were greater in the silicone implant group.
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2007
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oai:scielo:S0102-865020070003000062007-05-24Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in ratsHaddad Filho,DouglasZveibel,Deborah K.Alonso,NivaldoGemperli,Rolf Silicone Elastomers Silicone Gels Polytetrafluoroethylene Rats, Wistar PURPOSE: Comparison of the inflammatory reaction promoted by textured silicone implants and that caused by the implant bonded with e-ptfe. METHODS: One-hundred and fifty rats were divided into three equal groups (control, silicone, and bonded e-ptfe). These groups were subdivided into five groups, according to the second operation, i.e., 7,30,60,90 and 180 days. Histology of the peri-implant tissue was analyzed by morphometry with blood count (neutrophilos, lymphocytes, macrophages, fibroblasts and capillaries). RESULTS: Comparison of subgroups 7,30,60,90, 180 days: - neutrophils: silicone: > in subgroup 7 days; bonded e-ptfe: > in subgroups 7 and 30 days; - lymphocytes: silicone: > in subgroup 7 and 180 days; bonded e-ptfe: > in subgroup 180 days; - macrophages: silicone: > in subgroup 7 and 60 days; bonded e-ptfe: > in subgroup 7,30 and 60 days; - fibroblasts: silicone: > in subgroup 30 and 60 days;- vascular volume: silicone: in subgroup 7, 60 and 90 days; bonded e-ptfe: > in subgroup 7 days. Comparison of groups: neutrophils : 7 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe; - lymphocytes: - 7,30,90 and 180 days: in the control; macrophages: - 7,30 and 60 days: > in silicone & bonded e-ptfe; 180 days > in silicone; fibroblasts: - 7,30 and 90 days: > in silicone and bonded e-ptfe; 180 days: > in bonded e-ptfe; vascular volume 7,60,90 and 180 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe. CONCLUSIONS: The acute stage of the inflammatory response was more severe and irregular in the silicone implant; both the silicone implant and the silicone bonded with e-ptfe promoted chronic inflammatory reaction and weak foreign body inflammatory response. These reactions were greater in the silicone implant group.info:eu-repo/semantics/openAccessSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira v.22 n.3 20072007-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000300006en10.1590/S0102-86502007000300006 |
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Haddad Filho,Douglas Zveibel,Deborah K. Alonso,Nivaldo Gemperli,Rolf |
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Haddad Filho,Douglas Zveibel,Deborah K. Alonso,Nivaldo Gemperli,Rolf Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats |
author_facet |
Haddad Filho,Douglas Zveibel,Deborah K. Alonso,Nivaldo Gemperli,Rolf |
author_sort |
Haddad Filho,Douglas |
title |
Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats |
title_short |
Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats |
title_full |
Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats |
title_fullStr |
Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats |
title_full_unstemmed |
Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats |
title_sort |
comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats |
description |
PURPOSE: Comparison of the inflammatory reaction promoted by textured silicone implants and that caused by the implant bonded with e-ptfe. METHODS: One-hundred and fifty rats were divided into three equal groups (control, silicone, and bonded e-ptfe). These groups were subdivided into five groups, according to the second operation, i.e., 7,30,60,90 and 180 days. Histology of the peri-implant tissue was analyzed by morphometry with blood count (neutrophilos, lymphocytes, macrophages, fibroblasts and capillaries). RESULTS: Comparison of subgroups 7,30,60,90, 180 days: - neutrophils: silicone: > in subgroup 7 days; bonded e-ptfe: > in subgroups 7 and 30 days; - lymphocytes: silicone: > in subgroup 7 and 180 days; bonded e-ptfe: > in subgroup 180 days; - macrophages: silicone: > in subgroup 7 and 60 days; bonded e-ptfe: > in subgroup 7,30 and 60 days; - fibroblasts: silicone: > in subgroup 30 and 60 days;- vascular volume: silicone: in subgroup 7, 60 and 90 days; bonded e-ptfe: > in subgroup 7 days. Comparison of groups: neutrophils : 7 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe; - lymphocytes: - 7,30,90 and 180 days: in the control; macrophages: - 7,30 and 60 days: > in silicone & bonded e-ptfe; 180 days > in silicone; fibroblasts: - 7,30 and 90 days: > in silicone and bonded e-ptfe; 180 days: > in bonded e-ptfe; vascular volume 7,60,90 and 180 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe. CONCLUSIONS: The acute stage of the inflammatory response was more severe and irregular in the silicone implant; both the silicone implant and the silicone bonded with e-ptfe promoted chronic inflammatory reaction and weak foreign body inflammatory response. These reactions were greater in the silicone implant group. |
publisher |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
publishDate |
2007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000300006 |
work_keys_str_mv |
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1756400828326871040 |