Anticonvulsant activity of thymoquinone and its structural analogues
It has been widely reported that the crude oil of Nigella sativa L., Ranunculaceae, seeds and its major chemical component thymoquinone present anticonvulsant activity. These facts led us to verify the pharmacological potential of five structurally related para-benzoquinones on the pentylenotetrazol-induced seizures model, and establish the structural characteristics that influence the anticonvulsant activity of thymoquinone. The unsubstituted para-benzoquinone was the compound that exhibited the highest potency, while 2-methyl-p-benzoquinone was inactive. It was found that the presence of alkyl groups attached to the ring influence the pharmacological activity of the para-benzoquinones. In addition, the number, position, and size of these groups change the anticonvulsant potency of the compounds.
Main Authors: | Sousa,Damião P. de, Nóbrega,Franklin F. F., Santos,Camila C. M. P., Benedito,Rubens B., Vieira,Ygor W., Uliana,Marciana P., Brocksom,Timothy J., Almeida,Reinaldo N. de |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Sociedade Brasileira de Farmacognosia
2011
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300012 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF N-BENZOYL-TRYPTAMINE AND ITS NEW ANALOGUE N-SALICYLOYLTRYPTAMINE, A POTENTIAL ANTICONVULSANT AGENT
by: ASSIS OLIVEIRA,FRANCISCO DE, et al.
Published: (2006) -
Oxidation of mono-phenols to para-benzoquinones: a comparative study
by: Uliana,Marciana P., et al.
Published: (2008) -
A reação de Diels-Alder no início do século vinte um
by: Brocksom,Timothy John, et al.
Published: (2010) -
On the anticonvulsant activity of kaurenic acid
by: Daló,Nelson L, et al.
Published: (2007) -
Plants with anticonvulsant properties: a review
by: Quintans Júnior,Lucindo J., et al.
Published: (2008)