Hepatotoxicity induced by antituberculosis drugs among patients coinfected with HIV and tuberculosis
Hepatotoxicity due to antituberculosis drugs limits treatment in patients coinfected with HIV and tuberculosis. We conducted a case-control study to identify risk factors for hepatotoxicity among patients coinfected with tuberculosis and HIV in two hospitals in Recife, Pernambuco State, Brazil. The sample consisted of 57 patients (36.5% of the total) who developed hepatotoxicity and a control group of 99 patients (63.5% of the total), who did not present this effect. Hepatotoxicity consisted of jaundice or a high concentration of AST/ALT or total bilirubinemia. Multivariate logistic regression showed that a T CD4+ count of < 200cells/mm³ increased the risk of hepatotoxicity by a factor of 1.233 (p < 0.001) and that coinfection with hepatitis B or C virus increased this risk by a factor of 18.187 (p = 0.029). Discharge occurred among 66.1% of the case group (p = 0.026). The absence of hepatotoxicity was a protective factor against death (OR = 0.42; 95%CI: 0.20-0.91). Coinfection with the B and C hepatitis virus and a T CD4+ cell count below 200cells/mm³ were independent risk factors for hepatotoxicity in these patients
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Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
2012
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oai:scielo:S0102-311X20120004000092012-04-05Hepatotoxicity induced by antituberculosis drugs among patients coinfected with HIV and tuberculosisLima,Maria de Fátima Silva deMelo,Heloísa Ramos Lacerda de Drug Toxicity Coinfection Tuberculosis HIV Hepatotoxicity due to antituberculosis drugs limits treatment in patients coinfected with HIV and tuberculosis. We conducted a case-control study to identify risk factors for hepatotoxicity among patients coinfected with tuberculosis and HIV in two hospitals in Recife, Pernambuco State, Brazil. The sample consisted of 57 patients (36.5% of the total) who developed hepatotoxicity and a control group of 99 patients (63.5% of the total), who did not present this effect. Hepatotoxicity consisted of jaundice or a high concentration of AST/ALT or total bilirubinemia. Multivariate logistic regression showed that a T CD4+ count of < 200cells/mm³ increased the risk of hepatotoxicity by a factor of 1.233 (p < 0.001) and that coinfection with hepatitis B or C virus increased this risk by a factor of 18.187 (p = 0.029). Discharge occurred among 66.1% of the case group (p = 0.026). The absence of hepatotoxicity was a protective factor against death (OR = 0.42; 95%CI: 0.20-0.91). Coinfection with the B and C hepatitis virus and a T CD4+ cell count below 200cells/mm³ were independent risk factors for hepatotoxicity in these patientsinfo:eu-repo/semantics/openAccessEscola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo CruzCadernos de Saúde Pública v.28 n.4 20122012-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2012000400009en10.1590/S0102-311X2012000400009 |
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Lima,Maria de Fátima Silva de Melo,Heloísa Ramos Lacerda de |
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Lima,Maria de Fátima Silva de Melo,Heloísa Ramos Lacerda de Hepatotoxicity induced by antituberculosis drugs among patients coinfected with HIV and tuberculosis |
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Lima,Maria de Fátima Silva de Melo,Heloísa Ramos Lacerda de |
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Lima,Maria de Fátima Silva de |
title |
Hepatotoxicity induced by antituberculosis drugs among patients coinfected with HIV and tuberculosis |
title_short |
Hepatotoxicity induced by antituberculosis drugs among patients coinfected with HIV and tuberculosis |
title_full |
Hepatotoxicity induced by antituberculosis drugs among patients coinfected with HIV and tuberculosis |
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Hepatotoxicity induced by antituberculosis drugs among patients coinfected with HIV and tuberculosis |
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Hepatotoxicity induced by antituberculosis drugs among patients coinfected with HIV and tuberculosis |
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hepatotoxicity induced by antituberculosis drugs among patients coinfected with hiv and tuberculosis |
description |
Hepatotoxicity due to antituberculosis drugs limits treatment in patients coinfected with HIV and tuberculosis. We conducted a case-control study to identify risk factors for hepatotoxicity among patients coinfected with tuberculosis and HIV in two hospitals in Recife, Pernambuco State, Brazil. The sample consisted of 57 patients (36.5% of the total) who developed hepatotoxicity and a control group of 99 patients (63.5% of the total), who did not present this effect. Hepatotoxicity consisted of jaundice or a high concentration of AST/ALT or total bilirubinemia. Multivariate logistic regression showed that a T CD4+ count of < 200cells/mm³ increased the risk of hepatotoxicity by a factor of 1.233 (p < 0.001) and that coinfection with hepatitis B or C virus increased this risk by a factor of 18.187 (p = 0.029). Discharge occurred among 66.1% of the case group (p = 0.026). The absence of hepatotoxicity was a protective factor against death (OR = 0.42; 95%CI: 0.20-0.91). Coinfection with the B and C hepatitis virus and a T CD4+ cell count below 200cells/mm³ were independent risk factors for hepatotoxicity in these patients |
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Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz |
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2012 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2012000400009 |
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AT limamariadefatimasilvade hepatotoxicityinducedbyantituberculosisdrugsamongpatientscoinfectedwithhivandtuberculosis AT meloheloisaramoslacerdade hepatotoxicityinducedbyantituberculosisdrugsamongpatientscoinfectedwithhivandtuberculosis |
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