What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?

What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?

The T helper cell type 1 (Th1) response is essential to resist leishmaniasis, whereas the Th2 response favors the disease. However, many leishmanial antigens, which stimulate a Th1 immune response during the disease or even after the disease is cured, have been shown to have no protective action. Paradoxically, antigens associated with an early Th2 response have been found to be highly protective if the Th1 response to them is generated before infection. Therefore, finding disease-associated Th2 antigens and inducing a Th1 immune response to them using defined vaccination protocols is an interesting unorthodox alternative approach to the discovery of a leishmania vaccine.

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Main Author: Campos-Neto,A.
Format: Digital revista
Language:English
Published: Associação Brasileira de Divulgação Científica 2005
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700001
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spelling oai:scielo:S0100-879X20050007000012005-07-04What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?Campos-Neto,A. Leishmania Th1/Th2 paradigm Infection Vaccine Antigen discovery Adjuvant The T helper cell type 1 (Th1) response is essential to resist leishmaniasis, whereas the Th2 response favors the disease. However, many leishmanial antigens, which stimulate a Th1 immune response during the disease or even after the disease is cured, have been shown to have no protective action. Paradoxically, antigens associated with an early Th2 response have been found to be highly protective if the Th1 response to them is generated before infection. Therefore, finding disease-associated Th2 antigens and inducing a Th1 immune response to them using defined vaccination protocols is an interesting unorthodox alternative approach to the discovery of a leishmania vaccine.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.38 n.7 20052005-07-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700001en10.1590/S0100-879X2005000700001
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country Brasil
countrycode BR
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libraryname SciELO
language English
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author Campos-Neto,A.
spellingShingle Campos-Neto,A.
What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
author_facet Campos-Neto,A.
author_sort Campos-Neto,A.
title What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
title_short What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
title_full What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
title_fullStr What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
title_full_unstemmed What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery?
title_sort what about th1/th2 in cutaneous leishmaniasis vaccine discovery?
description The T helper cell type 1 (Th1) response is essential to resist leishmaniasis, whereas the Th2 response favors the disease. However, many leishmanial antigens, which stimulate a Th1 immune response during the disease or even after the disease is cured, have been shown to have no protective action. Paradoxically, antigens associated with an early Th2 response have been found to be highly protective if the Th1 response to them is generated before infection. Therefore, finding disease-associated Th2 antigens and inducing a Th1 immune response to them using defined vaccination protocols is an interesting unorthodox alternative approach to the discovery of a leishmania vaccine.
publisher Associação Brasileira de Divulgação Científica
publishDate 2005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700001
work_keys_str_mv AT camposnetoa whataboutth1th2incutaneousleishmaniasisvaccinediscovery
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