Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man
To examine the possible age-related blood pressure (BP) deregulation in response to central hypervolemia, we measured spontaneous baroreflex sensitivity (SBRS), carotid arterial compliance (CC), and R-R interval coefficient of variation (RRICV) during basal and thermoneutral resting head-out-of-water immersion (HOWI) in 7 young (YG = 24.0 ± 0.8 years) and 6 middle-aged/older (OL = 59.3 ± 1.3 years) healthy men. Compared with basal conditions (YG = 19.6 ± 4.0 vs OL = 6.1 ± 1.5 ms/mmHg, P < 0.05), SBRS remained higher in YG than OL during rest HOWI (YG = 23.6 ± 6.6 vs OL = 9.3 ± 2.1 ms/mmHg, P < 0.05). The RRICV was significantly different between groups (YG = 6.5 ± 1.4 vs OL = 2.8 ± 0.4%, P < 0.05) under HOWI. The OL group had no increase in CC, but a significant increase in systolic BP (basal = 115.3 ± 4.4 vs water = 129.3 ± 5.3 mmHg, P < 0.05) under HOWI. In contrast, the YG group had a significant increase in CC (basal = 0.16 ± 0.01 vs water = 0.17 ± 0.02 mm²/mmHg, P < 0.05) with no changes in systolic BP. SBRS was positively related to CC (r = 0.58, P < 0.05 for basal vs r = 0.62, P < 0.05 for water). Our data suggest that age-related vagal dysfunction and reduced CC may be associated with SBRS differences between YG and OL groups, and with BP elevation during HOWI in healthy older men.
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Associação Brasileira de Divulgação Científica
2005
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oai:scielo:S0100-879X20050004000182005-04-13Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in manUeno,L.M.Miyachi,M.Matsui,T.Takahashi,K.Yamazaki,K.Hayashi,K.Onodera,S.Moritani,T. Aging Baroreflex sensitivity Carotid compliance Water immersion Hypertension Vascular stiffness To examine the possible age-related blood pressure (BP) deregulation in response to central hypervolemia, we measured spontaneous baroreflex sensitivity (SBRS), carotid arterial compliance (CC), and R-R interval coefficient of variation (RRICV) during basal and thermoneutral resting head-out-of-water immersion (HOWI) in 7 young (YG = 24.0 ± 0.8 years) and 6 middle-aged/older (OL = 59.3 ± 1.3 years) healthy men. Compared with basal conditions (YG = 19.6 ± 4.0 vs OL = 6.1 ± 1.5 ms/mmHg, P < 0.05), SBRS remained higher in YG than OL during rest HOWI (YG = 23.6 ± 6.6 vs OL = 9.3 ± 2.1 ms/mmHg, P < 0.05). The RRICV was significantly different between groups (YG = 6.5 ± 1.4 vs OL = 2.8 ± 0.4%, P < 0.05) under HOWI. The OL group had no increase in CC, but a significant increase in systolic BP (basal = 115.3 ± 4.4 vs water = 129.3 ± 5.3 mmHg, P < 0.05) under HOWI. In contrast, the YG group had a significant increase in CC (basal = 0.16 ± 0.01 vs water = 0.17 ± 0.02 mm²/mmHg, P < 0.05) with no changes in systolic BP. SBRS was positively related to CC (r = 0.58, P < 0.05 for basal vs r = 0.62, P < 0.05 for water). Our data suggest that age-related vagal dysfunction and reduced CC may be associated with SBRS differences between YG and OL groups, and with BP elevation during HOWI in healthy older men.info:eu-repo/semantics/openAccessAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.38 n.4 20052005-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400018en10.1590/S0100-879X2005000400018 |
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Ueno,L.M. Miyachi,M. Matsui,T. Takahashi,K. Yamazaki,K. Hayashi,K. Onodera,S. Moritani,T. |
spellingShingle |
Ueno,L.M. Miyachi,M. Matsui,T. Takahashi,K. Yamazaki,K. Hayashi,K. Onodera,S. Moritani,T. Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man |
author_facet |
Ueno,L.M. Miyachi,M. Matsui,T. Takahashi,K. Yamazaki,K. Hayashi,K. Onodera,S. Moritani,T. |
author_sort |
Ueno,L.M. |
title |
Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man |
title_short |
Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man |
title_full |
Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man |
title_fullStr |
Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man |
title_full_unstemmed |
Effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man |
title_sort |
effect of aging on carotid artery stiffness and baroreflex sensitivity during head-out water immersion in man |
description |
To examine the possible age-related blood pressure (BP) deregulation in response to central hypervolemia, we measured spontaneous baroreflex sensitivity (SBRS), carotid arterial compliance (CC), and R-R interval coefficient of variation (RRICV) during basal and thermoneutral resting head-out-of-water immersion (HOWI) in 7 young (YG = 24.0 ± 0.8 years) and 6 middle-aged/older (OL = 59.3 ± 1.3 years) healthy men. Compared with basal conditions (YG = 19.6 ± 4.0 vs OL = 6.1 ± 1.5 ms/mmHg, P < 0.05), SBRS remained higher in YG than OL during rest HOWI (YG = 23.6 ± 6.6 vs OL = 9.3 ± 2.1 ms/mmHg, P < 0.05). The RRICV was significantly different between groups (YG = 6.5 ± 1.4 vs OL = 2.8 ± 0.4%, P < 0.05) under HOWI. The OL group had no increase in CC, but a significant increase in systolic BP (basal = 115.3 ± 4.4 vs water = 129.3 ± 5.3 mmHg, P < 0.05) under HOWI. In contrast, the YG group had a significant increase in CC (basal = 0.16 ± 0.01 vs water = 0.17 ± 0.02 mm²/mmHg, P < 0.05) with no changes in systolic BP. SBRS was positively related to CC (r = 0.58, P < 0.05 for basal vs r = 0.62, P < 0.05 for water). Our data suggest that age-related vagal dysfunction and reduced CC may be associated with SBRS differences between YG and OL groups, and with BP elevation during HOWI in healthy older men. |
publisher |
Associação Brasileira de Divulgação Científica |
publishDate |
2005 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400018 |
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