Correlation between PET/CT results and histological and immunohistochemical findings in breast carcinomas
Objective To correlate the results of 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) performed with a specific protocol for assessment of breasts with histological/immunohistochemical findings in breast carcinoma patients. Materials and Methods Cross-sectional study with prospective data collection, where patients with biopsy-confirmed breast carcinomas were studied. The patients underwent PET/CT examination in prone position, with a specific protocol for assessment of breasts. PET/CT findings were compared with histological and immunohistochemical data. Results The authors identified 59 malignant breast lesions in 50 patients. The maximum diameter of the lesions ranged from 6 to 80 mm (mean: 32.2 mm). Invasive ductal carcinoma was the most common histological type (n = 47; 79.7%). At PET/CT, 53 (89.8%) of the lesions demonstrated anomalous concentrations of 18F-FDG, with maximum SUV ranging from 0.8 to 23.1 (mean: 5.5). A statistically significant association was observed between higher values of maximum SUV and histological type, histological grade, molecular subtype, tumor diameter, mitotic index and Ki-67 expression. Conclusion PET/CT performed with specific protocol for assessment of breasts has demonstrated good sensitivity and was associated with relevant histological/immunohistochemical factors related to aggressiveness and prognosis of breast carcinomas.
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Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
2014
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oai:scielo:S0100-398420140002000062015-08-31Correlation between PET/CT results and histological and immunohistochemical findings in breast carcinomasBitencourt,Almir Galvão VieiraLima,Eduardo Nóbrega PereiraChojniak,RubensMarques,Elvira FerreiraSouza,Juliana Alves deGraziano,LucianaAndrade,Wesley PereiraOsório,Cynthia Aparecida Bueno de Toledo Breast cancer PET/CT Histology Objective To correlate the results of 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) performed with a specific protocol for assessment of breasts with histological/immunohistochemical findings in breast carcinoma patients. Materials and Methods Cross-sectional study with prospective data collection, where patients with biopsy-confirmed breast carcinomas were studied. The patients underwent PET/CT examination in prone position, with a specific protocol for assessment of breasts. PET/CT findings were compared with histological and immunohistochemical data. Results The authors identified 59 malignant breast lesions in 50 patients. The maximum diameter of the lesions ranged from 6 to 80 mm (mean: 32.2 mm). Invasive ductal carcinoma was the most common histological type (n = 47; 79.7%). At PET/CT, 53 (89.8%) of the lesions demonstrated anomalous concentrations of 18F-FDG, with maximum SUV ranging from 0.8 to 23.1 (mean: 5.5). A statistically significant association was observed between higher values of maximum SUV and histological type, histological grade, molecular subtype, tumor diameter, mitotic index and Ki-67 expression. Conclusion PET/CT performed with specific protocol for assessment of breasts has demonstrated good sensitivity and was associated with relevant histological/immunohistochemical factors related to aggressiveness and prognosis of breast carcinomas. info:eu-repo/semantics/openAccessPublicação do Colégio Brasileiro de Radiologia e Diagnóstico por ImagemRadiologia Brasileira v.47 n.2 20142014-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842014000200006en10.1590/S0100-39842014000200006 |
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Bitencourt,Almir Galvão Vieira Lima,Eduardo Nóbrega Pereira Chojniak,Rubens Marques,Elvira Ferreira Souza,Juliana Alves de Graziano,Luciana Andrade,Wesley Pereira Osório,Cynthia Aparecida Bueno de Toledo |
| spellingShingle |
Bitencourt,Almir Galvão Vieira Lima,Eduardo Nóbrega Pereira Chojniak,Rubens Marques,Elvira Ferreira Souza,Juliana Alves de Graziano,Luciana Andrade,Wesley Pereira Osório,Cynthia Aparecida Bueno de Toledo Correlation between PET/CT results and histological and immunohistochemical findings in breast carcinomas |
| author_facet |
Bitencourt,Almir Galvão Vieira Lima,Eduardo Nóbrega Pereira Chojniak,Rubens Marques,Elvira Ferreira Souza,Juliana Alves de Graziano,Luciana Andrade,Wesley Pereira Osório,Cynthia Aparecida Bueno de Toledo |
| author_sort |
Bitencourt,Almir Galvão Vieira |
| title |
Correlation between PET/CT results and histological and immunohistochemical findings in breast carcinomas |
| title_short |
Correlation between PET/CT results and histological and immunohistochemical findings in breast carcinomas |
| title_full |
Correlation between PET/CT results and histological and immunohistochemical findings in breast carcinomas |
| title_fullStr |
Correlation between PET/CT results and histological and immunohistochemical findings in breast carcinomas |
| title_full_unstemmed |
Correlation between PET/CT results and histological and immunohistochemical findings in breast carcinomas |
| title_sort |
correlation between pet/ct results and histological and immunohistochemical findings in breast carcinomas |
| description |
Objective To correlate the results of 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) performed with a specific protocol for assessment of breasts with histological/immunohistochemical findings in breast carcinoma patients. Materials and Methods Cross-sectional study with prospective data collection, where patients with biopsy-confirmed breast carcinomas were studied. The patients underwent PET/CT examination in prone position, with a specific protocol for assessment of breasts. PET/CT findings were compared with histological and immunohistochemical data. Results The authors identified 59 malignant breast lesions in 50 patients. The maximum diameter of the lesions ranged from 6 to 80 mm (mean: 32.2 mm). Invasive ductal carcinoma was the most common histological type (n = 47; 79.7%). At PET/CT, 53 (89.8%) of the lesions demonstrated anomalous concentrations of 18F-FDG, with maximum SUV ranging from 0.8 to 23.1 (mean: 5.5). A statistically significant association was observed between higher values of maximum SUV and histological type, histological grade, molecular subtype, tumor diameter, mitotic index and Ki-67 expression. Conclusion PET/CT performed with specific protocol for assessment of breasts has demonstrated good sensitivity and was associated with relevant histological/immunohistochemical factors related to aggressiveness and prognosis of breast carcinomas. |
| publisher |
Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
| publishDate |
2014 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842014000200006 |
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