Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents

Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents

This study shows an experimental spillover infection of Sigmodontinae rodents with Rio Mamore hantavirus (RIOMV). Necromys lasiurus and Akodon sp were infected with 103 RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals.

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Main Authors: Souza,William Marciel de, Machado,Alex Martins, Figueiredo,Luiz Tadeu Moraes
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2016
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000600399
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spelling oai:scielo:S0074-027620160006003992016-06-09Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodentsSouza,William Marciel deMachado,Alex MartinsFigueiredo,Luiz Tadeu Moraes experimental infection Rio Mamore hantavirus wild Sigmodontinae rodents This study shows an experimental spillover infection of Sigmodontinae rodents with Rio Mamore hantavirus (RIOMV). Necromys lasiurus and Akodon sp were infected with 103 RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.111 n.6 20162016-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000600399en10.1590/0074-02760160021
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Souza,William Marciel de
Machado,Alex Martins
Figueiredo,Luiz Tadeu Moraes
spellingShingle Souza,William Marciel de
Machado,Alex Martins
Figueiredo,Luiz Tadeu Moraes
Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
author_facet Souza,William Marciel de
Machado,Alex Martins
Figueiredo,Luiz Tadeu Moraes
author_sort Souza,William Marciel de
title Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
title_short Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
title_full Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
title_fullStr Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
title_full_unstemmed Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents
title_sort experimental infection of rio mamore hantavirus in sigmodontinae rodents
description This study shows an experimental spillover infection of Sigmodontinae rodents with Rio Mamore hantavirus (RIOMV). Necromys lasiurus and Akodon sp were infected with 103 RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 2016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762016000600399
work_keys_str_mv AT souzawilliammarcielde experimentalinfectionofriomamorehantavirusinsigmodontinaerodents
AT machadoalexmartins experimentalinfectionofriomamorehantavirusinsigmodontinaerodents
AT figueiredoluiztadeumoraes experimentalinfectionofriomamorehantavirusinsigmodontinaerodents
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