Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assay
Angiostrongylus costaricensis may cause intestinal lesions of varied severity when it accidentally infects man in Central and South America. First-stage larvae have never been detected in stools. Therefore, a parasite-specific IgG ELISA was evaluated for the determination of the acute phase of infection. The specificity and the sensitivity of the immunoassay was shown to be 76.2% and 91.1%, respectively. Eight serum samples taken from patients with histopathological diagnosis, at different time points (3 to 15 months) after surgical treatment, showed a sharp and early decline in antibody reactivity. The titration of anti-A. costaricensis antibodies has proved to be a useful method for the diagnosis of acute abdominal angiostrongyliasis.
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Instituto Oswaldo Cruz, Ministério da Saúde
2001
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oai:scielo:S0074-027620010004000122001-05-31Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assayGeiger,Stefan MichaelLaitano,Antônio CarloSievers-Tostes,CharlotteAgostini,Aventino AlfredoSchulz-Key,HartwigGraeff-Teixeira,Carlos abdominal angiostrongyliasis serology eosinophilic gastroenteritis immunodiagnosis Angiostrongylus costaricensis may cause intestinal lesions of varied severity when it accidentally infects man in Central and South America. First-stage larvae have never been detected in stools. Therefore, a parasite-specific IgG ELISA was evaluated for the determination of the acute phase of infection. The specificity and the sensitivity of the immunoassay was shown to be 76.2% and 91.1%, respectively. Eight serum samples taken from patients with histopathological diagnosis, at different time points (3 to 15 months) after surgical treatment, showed a sharp and early decline in antibody reactivity. The titration of anti-A. costaricensis antibodies has proved to be a useful method for the diagnosis of acute abdominal angiostrongyliasis.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.96 n.4 20012001-05-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000400012en10.1590/S0074-02762001000400012 |
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| author |
Geiger,Stefan Michael Laitano,Antônio Carlo Sievers-Tostes,Charlotte Agostini,Aventino Alfredo Schulz-Key,Hartwig Graeff-Teixeira,Carlos |
| spellingShingle |
Geiger,Stefan Michael Laitano,Antônio Carlo Sievers-Tostes,Charlotte Agostini,Aventino Alfredo Schulz-Key,Hartwig Graeff-Teixeira,Carlos Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assay |
| author_facet |
Geiger,Stefan Michael Laitano,Antônio Carlo Sievers-Tostes,Charlotte Agostini,Aventino Alfredo Schulz-Key,Hartwig Graeff-Teixeira,Carlos |
| author_sort |
Geiger,Stefan Michael |
| title |
Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assay |
| title_short |
Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assay |
| title_full |
Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assay |
| title_fullStr |
Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assay |
| title_full_unstemmed |
Detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific IgG enzyme linked immunosorbent assay |
| title_sort |
detection of the acute phase of abdominal angiostrongyliasis with a parasite-specific igg enzyme linked immunosorbent assay |
| description |
Angiostrongylus costaricensis may cause intestinal lesions of varied severity when it accidentally infects man in Central and South America. First-stage larvae have never been detected in stools. Therefore, a parasite-specific IgG ELISA was evaluated for the determination of the acute phase of infection. The specificity and the sensitivity of the immunoassay was shown to be 76.2% and 91.1%, respectively. Eight serum samples taken from patients with histopathological diagnosis, at different time points (3 to 15 months) after surgical treatment, showed a sharp and early decline in antibody reactivity. The titration of anti-A. costaricensis antibodies has proved to be a useful method for the diagnosis of acute abdominal angiostrongyliasis. |
| publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
| publishDate |
2001 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000400012 |
| work_keys_str_mv |
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