Genotoxic effect of alkaloids

Genotoxic effect of alkaloids

Because of the increase use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotixicity in the presence of a metabolic activation mixture. Voacristine isolated fromthe leaves of Ervatamia coronaria shows in vivo cytostatic and mutagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.

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Main Authors: Henriques,J. A. P., Moreno,P. R. H., Von Poser,G. L., Querol,C. C., Henriques,A. T.
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 1991
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600018
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spelling oai:scielo:S0074-027619910006000182009-06-24Genotoxic effect of alkaloidsHenriques,J. A. P.Moreno,P. R. H.Von Poser,G. L.Querol,C. C.Henriques,A. T. alkaloids SOS-Chromotest Saccharomyces cerevisiae mutation recombination Because of the increase use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotixicity in the presence of a metabolic activation mixture. Voacristine isolated fromthe leaves of Ervatamia coronaria shows in vivo cytostatic and mutagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.86 suppl.2 19911991-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600018en10.1590/S0074-02761991000600018
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country Brasil
countrycode BR
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databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Henriques,J. A. P.
Moreno,P. R. H.
Von Poser,G. L.
Querol,C. C.
Henriques,A. T.
spellingShingle Henriques,J. A. P.
Moreno,P. R. H.
Von Poser,G. L.
Querol,C. C.
Henriques,A. T.
Genotoxic effect of alkaloids
author_facet Henriques,J. A. P.
Moreno,P. R. H.
Von Poser,G. L.
Querol,C. C.
Henriques,A. T.
author_sort Henriques,J. A. P.
title Genotoxic effect of alkaloids
title_short Genotoxic effect of alkaloids
title_full Genotoxic effect of alkaloids
title_fullStr Genotoxic effect of alkaloids
title_full_unstemmed Genotoxic effect of alkaloids
title_sort genotoxic effect of alkaloids
description Because of the increase use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotixicity in the presence of a metabolic activation mixture. Voacristine isolated fromthe leaves of Ervatamia coronaria shows in vivo cytostatic and mutagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 1991
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600018
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AT vonposergl genotoxiceffectofalkaloids
AT querolcc genotoxiceffectofalkaloids
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