Study on thermostabilizers for trivalent oral poliomyelitis vaccine

Study on thermostabilizers for trivalent oral poliomyelitis vaccine

Different formulations of trivalent oral poliomyelitis vaccine were tested, in order to obtain better thermostability, reduce corrosion of machinery and improve production costs. Magnesium chloride, sucrose, arginine and 199-Hank's medium were used in the formulations. The most appropriate formulation was a mixture of MgCl2 and arginine, which was highly thermostable, and had low production costs. The low corrosive formulation was rejected, due to low thermostability on storage.

Saved in:
Bibliographic Details
Main Authors: Leal,M. L. F., Lopes,F. J. C., Carvalho,M. H. G., Moura,H. A. B., Soares,S. A. F.
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 1990
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000300010
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S0074-02761990000300010
record_format ojs
spelling oai:scielo:S0074-027619900003000102009-06-04Study on thermostabilizers for trivalent oral poliomyelitis vaccineLeal,M. L. F.Lopes,F. J. C.Carvalho,M. H. G.Moura,H. A. B.Soares,S. A. F. poliovaccine thermostabilizers Different formulations of trivalent oral poliomyelitis vaccine were tested, in order to obtain better thermostability, reduce corrosion of machinery and improve production costs. Magnesium chloride, sucrose, arginine and 199-Hank's medium were used in the formulations. The most appropriate formulation was a mixture of MgCl2 and arginine, which was highly thermostable, and had low production costs. The low corrosive formulation was rejected, due to low thermostability on storage.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.85 n.3 19901990-09-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000300010en10.1590/S0074-02761990000300010
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Leal,M. L. F.
Lopes,F. J. C.
Carvalho,M. H. G.
Moura,H. A. B.
Soares,S. A. F.
spellingShingle Leal,M. L. F.
Lopes,F. J. C.
Carvalho,M. H. G.
Moura,H. A. B.
Soares,S. A. F.
Study on thermostabilizers for trivalent oral poliomyelitis vaccine
author_facet Leal,M. L. F.
Lopes,F. J. C.
Carvalho,M. H. G.
Moura,H. A. B.
Soares,S. A. F.
author_sort Leal,M. L. F.
title Study on thermostabilizers for trivalent oral poliomyelitis vaccine
title_short Study on thermostabilizers for trivalent oral poliomyelitis vaccine
title_full Study on thermostabilizers for trivalent oral poliomyelitis vaccine
title_fullStr Study on thermostabilizers for trivalent oral poliomyelitis vaccine
title_full_unstemmed Study on thermostabilizers for trivalent oral poliomyelitis vaccine
title_sort study on thermostabilizers for trivalent oral poliomyelitis vaccine
description Different formulations of trivalent oral poliomyelitis vaccine were tested, in order to obtain better thermostability, reduce corrosion of machinery and improve production costs. Magnesium chloride, sucrose, arginine and 199-Hank's medium were used in the formulations. The most appropriate formulation was a mixture of MgCl2 and arginine, which was highly thermostable, and had low production costs. The low corrosive formulation was rejected, due to low thermostability on storage.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 1990
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761990000300010
work_keys_str_mv AT lealmlf studyonthermostabilizersfortrivalentoralpoliomyelitisvaccine
AT lopesfjc studyonthermostabilizersfortrivalentoralpoliomyelitisvaccine
AT carvalhomhg studyonthermostabilizersfortrivalentoralpoliomyelitisvaccine
AT mourahab studyonthermostabilizersfortrivalentoralpoliomyelitisvaccine
AT soaressaf studyonthermostabilizersfortrivalentoralpoliomyelitisvaccine
_version_ 1756383100528492545

Similar Items