Glomerulonephritis in schistosomiasis with mesangial IgM deposits
Twenty one cases of hepatoesplenic schistosomiasis patients without clinical and laboratory evidence of renal disease, were studied by surgical biopsies using light microscopy and immunofluorescence. The cases were classified histologically as: normal pattern (6 cases); minimal changes (6 cases); and mesangial proliferative glomerulonephritis (9 cases). By the immunofluorescence microscopy using anti IgM, IgG, IgA and C3, the predominant finding in all biopsies, except the normal cases, was granular deposits of IgM in the mesangium along with C3. On the other hand, IgG was present in all cases including normal biopsies along the capillary walls. However IgG was also present in the mesangium only in cases with glomerular lesions. This finding may well be similar to that recently described as IgM mesangial nephropathy. According to our cases a mesangial proliferative glomerulonephritis, characterized by segmental cell proliferation and deposition of IgM in the mesangium, is probably the entity found in the early stages of mansonic schistosomiasis.
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Instituto Oswaldo Cruz, Ministério da Saúde
1981
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oai:scielo:S0074-027619810002000092009-06-25Glomerulonephritis in schistosomiasis with mesangial IgM depositsMagalhães Filho,Ageu GodoyBarbosa,Antônio VictorianoFerreira,Teresa CristinaTwenty one cases of hepatoesplenic schistosomiasis patients without clinical and laboratory evidence of renal disease, were studied by surgical biopsies using light microscopy and immunofluorescence. The cases were classified histologically as: normal pattern (6 cases); minimal changes (6 cases); and mesangial proliferative glomerulonephritis (9 cases). By the immunofluorescence microscopy using anti IgM, IgG, IgA and C3, the predominant finding in all biopsies, except the normal cases, was granular deposits of IgM in the mesangium along with C3. On the other hand, IgG was present in all cases including normal biopsies along the capillary walls. However IgG was also present in the mesangium only in cases with glomerular lesions. This finding may well be similar to that recently described as IgM mesangial nephropathy. According to our cases a mesangial proliferative glomerulonephritis, characterized by segmental cell proliferation and deposition of IgM in the mesangium, is probably the entity found in the early stages of mansonic schistosomiasis.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.76 n.2 19811981-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761981000200009en10.1590/S0074-02761981000200009 |
| institution |
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| collection |
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| country |
Brasil |
| countrycode |
BR |
| component |
Revista |
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| databasecode |
rev-scielo-br |
| tag |
revista |
| region |
America del Sur |
| libraryname |
SciELO |
| language |
English |
| format |
Digital |
| author |
Magalhães Filho,Ageu Godoy Barbosa,Antônio Victoriano Ferreira,Teresa Cristina |
| spellingShingle |
Magalhães Filho,Ageu Godoy Barbosa,Antônio Victoriano Ferreira,Teresa Cristina Glomerulonephritis in schistosomiasis with mesangial IgM deposits |
| author_facet |
Magalhães Filho,Ageu Godoy Barbosa,Antônio Victoriano Ferreira,Teresa Cristina |
| author_sort |
Magalhães Filho,Ageu Godoy |
| title |
Glomerulonephritis in schistosomiasis with mesangial IgM deposits |
| title_short |
Glomerulonephritis in schistosomiasis with mesangial IgM deposits |
| title_full |
Glomerulonephritis in schistosomiasis with mesangial IgM deposits |
| title_fullStr |
Glomerulonephritis in schistosomiasis with mesangial IgM deposits |
| title_full_unstemmed |
Glomerulonephritis in schistosomiasis with mesangial IgM deposits |
| title_sort |
glomerulonephritis in schistosomiasis with mesangial igm deposits |
| description |
Twenty one cases of hepatoesplenic schistosomiasis patients without clinical and laboratory evidence of renal disease, were studied by surgical biopsies using light microscopy and immunofluorescence. The cases were classified histologically as: normal pattern (6 cases); minimal changes (6 cases); and mesangial proliferative glomerulonephritis (9 cases). By the immunofluorescence microscopy using anti IgM, IgG, IgA and C3, the predominant finding in all biopsies, except the normal cases, was granular deposits of IgM in the mesangium along with C3. On the other hand, IgG was present in all cases including normal biopsies along the capillary walls. However IgG was also present in the mesangium only in cases with glomerular lesions. This finding may well be similar to that recently described as IgM mesangial nephropathy. According to our cases a mesangial proliferative glomerulonephritis, characterized by segmental cell proliferation and deposition of IgM in the mesangium, is probably the entity found in the early stages of mansonic schistosomiasis. |
| publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
| publishDate |
1981 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761981000200009 |
| work_keys_str_mv |
AT magalhaesfilhoageugodoy glomerulonephritisinschistosomiasiswithmesangialigmdeposits AT barbosaantoniovictoriano glomerulonephritisinschistosomiasiswithmesangialigmdeposits AT ferreirateresacristina glomerulonephritisinschistosomiasiswithmesangialigmdeposits |
| _version_ |
1756382947388162048 |