Assessment of Myocardial Infarction by Cardiac Magnetic Resonance Imaging and Long-Term Mortality
Background: Cardiac magnetic resonance imaging provides detailed anatomical information on infarction. However, few studies have investigated the association of these data with mortality after acute myocardial infarction. Objective: To study the association between data regarding infarct size and anatomy, as obtained from cardiac magnetic resonance imaging after acute myocardial infarction, and long-term mortality. Methods: A total of 1959 reports of “infarct size” were identified in 7119 cardiac magnetic resonance imaging studies, of which 420 had clinical and laboratory confirmation of previous myocardial infarction. The variables studied were the classic risk factors – left ventricular ejection fraction, categorized ventricular function, and location of acute myocardial infarction. Infarct size and acute myocardial infarction extent and transmurality were analyzed alone and together, using the variable named “MET-AMI”. The statistical analysis was carried out using the elastic net regularization, with the Cox model and survival trees. Results: The mean age was 62.3 ± 12 years, and 77.3% were males. During the mean follow-up of 6.4 ± 2.9 years, there were 76 deaths (18.1%). Serum creatinine, diabetes mellitus and previous myocardial infarction were independently associated with mortality. Age was the main explanatory factor. The cardiac magnetic resonance imaging variables independently associated with mortality were transmurality of acute myocardial infarction (p = 0.047), ventricular dysfunction (p = 0.0005) and infarcted size (p = 0.0005); the latter was the main explanatory variable for ischemic heart disease death. The MET-AMI variable was the most strongly associated with risk of ischemic heart disease death (HR: 16.04; 95%CI: 2.64-97.5; p = 0.003). Conclusion: The anatomical data of infarction, obtained from cardiac magnetic resonance imaging after acute myocardial infarction, were independently associated with long-term mortality, especially for ischemic heart disease death.
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Sociedade Brasileira de Cardiologia - SBC
2015
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oai:scielo:S0066-782X20150002000102015-04-08Assessment of Myocardial Infarction by Cardiac Magnetic Resonance Imaging and Long-Term MortalityPetriz,João Luiz FernandesGomes,Bruno Ferraz de OliveiraRua,Braulio SantosAzevedo,Clério FranciscoHadlich,Marcelo SouzaMussi,Henrique Thadeu PeriardTaets,Gunnar de CuntoNascimento,Emília Matos doPereira,Basílio de BragançaSilva,Nelson Albuquerque de Souza e Myocardial Infarction/physiology; Magnetic Resonance Imaging Diagnostic Imaging Mortality Risk Factor Background: Cardiac magnetic resonance imaging provides detailed anatomical information on infarction. However, few studies have investigated the association of these data with mortality after acute myocardial infarction. Objective: To study the association between data regarding infarct size and anatomy, as obtained from cardiac magnetic resonance imaging after acute myocardial infarction, and long-term mortality. Methods: A total of 1959 reports of “infarct size” were identified in 7119 cardiac magnetic resonance imaging studies, of which 420 had clinical and laboratory confirmation of previous myocardial infarction. The variables studied were the classic risk factors – left ventricular ejection fraction, categorized ventricular function, and location of acute myocardial infarction. Infarct size and acute myocardial infarction extent and transmurality were analyzed alone and together, using the variable named “MET-AMI”. The statistical analysis was carried out using the elastic net regularization, with the Cox model and survival trees. Results: The mean age was 62.3 ± 12 years, and 77.3% were males. During the mean follow-up of 6.4 ± 2.9 years, there were 76 deaths (18.1%). Serum creatinine, diabetes mellitus and previous myocardial infarction were independently associated with mortality. Age was the main explanatory factor. The cardiac magnetic resonance imaging variables independently associated with mortality were transmurality of acute myocardial infarction (p = 0.047), ventricular dysfunction (p = 0.0005) and infarcted size (p = 0.0005); the latter was the main explanatory variable for ischemic heart disease death. The MET-AMI variable was the most strongly associated with risk of ischemic heart disease death (HR: 16.04; 95%CI: 2.64-97.5; p = 0.003). Conclusion: The anatomical data of infarction, obtained from cardiac magnetic resonance imaging after acute myocardial infarction, were independently associated with long-term mortality, especially for ischemic heart disease death. info:eu-repo/semantics/openAccessSociedade Brasileira de Cardiologia - SBCArquivos Brasileiros de Cardiologia v.104 n.2 20152015-02-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015000200010en10.5935/abc.20140177 |
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Petriz,João Luiz Fernandes Gomes,Bruno Ferraz de Oliveira Rua,Braulio Santos Azevedo,Clério Francisco Hadlich,Marcelo Souza Mussi,Henrique Thadeu Periard Taets,Gunnar de Cunto Nascimento,Emília Matos do Pereira,Basílio de Bragança Silva,Nelson Albuquerque de Souza e |
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Petriz,João Luiz Fernandes Gomes,Bruno Ferraz de Oliveira Rua,Braulio Santos Azevedo,Clério Francisco Hadlich,Marcelo Souza Mussi,Henrique Thadeu Periard Taets,Gunnar de Cunto Nascimento,Emília Matos do Pereira,Basílio de Bragança Silva,Nelson Albuquerque de Souza e Assessment of Myocardial Infarction by Cardiac Magnetic Resonance Imaging and Long-Term Mortality |
author_facet |
Petriz,João Luiz Fernandes Gomes,Bruno Ferraz de Oliveira Rua,Braulio Santos Azevedo,Clério Francisco Hadlich,Marcelo Souza Mussi,Henrique Thadeu Periard Taets,Gunnar de Cunto Nascimento,Emília Matos do Pereira,Basílio de Bragança Silva,Nelson Albuquerque de Souza e |
author_sort |
Petriz,João Luiz Fernandes |
title |
Assessment of Myocardial Infarction by Cardiac Magnetic Resonance Imaging and Long-Term Mortality |
title_short |
Assessment of Myocardial Infarction by Cardiac Magnetic Resonance Imaging and Long-Term Mortality |
title_full |
Assessment of Myocardial Infarction by Cardiac Magnetic Resonance Imaging and Long-Term Mortality |
title_fullStr |
Assessment of Myocardial Infarction by Cardiac Magnetic Resonance Imaging and Long-Term Mortality |
title_full_unstemmed |
Assessment of Myocardial Infarction by Cardiac Magnetic Resonance Imaging and Long-Term Mortality |
title_sort |
assessment of myocardial infarction by cardiac magnetic resonance imaging and long-term mortality |
description |
Background: Cardiac magnetic resonance imaging provides detailed anatomical information on infarction. However, few studies have investigated the association of these data with mortality after acute myocardial infarction. Objective: To study the association between data regarding infarct size and anatomy, as obtained from cardiac magnetic resonance imaging after acute myocardial infarction, and long-term mortality. Methods: A total of 1959 reports of “infarct size” were identified in 7119 cardiac magnetic resonance imaging studies, of which 420 had clinical and laboratory confirmation of previous myocardial infarction. The variables studied were the classic risk factors – left ventricular ejection fraction, categorized ventricular function, and location of acute myocardial infarction. Infarct size and acute myocardial infarction extent and transmurality were analyzed alone and together, using the variable named “MET-AMI”. The statistical analysis was carried out using the elastic net regularization, with the Cox model and survival trees. Results: The mean age was 62.3 ± 12 years, and 77.3% were males. During the mean follow-up of 6.4 ± 2.9 years, there were 76 deaths (18.1%). Serum creatinine, diabetes mellitus and previous myocardial infarction were independently associated with mortality. Age was the main explanatory factor. The cardiac magnetic resonance imaging variables independently associated with mortality were transmurality of acute myocardial infarction (p = 0.047), ventricular dysfunction (p = 0.0005) and infarcted size (p = 0.0005); the latter was the main explanatory variable for ischemic heart disease death. The MET-AMI variable was the most strongly associated with risk of ischemic heart disease death (HR: 16.04; 95%CI: 2.64-97.5; p = 0.003). Conclusion: The anatomical data of infarction, obtained from cardiac magnetic resonance imaging after acute myocardial infarction, were independently associated with long-term mortality, especially for ischemic heart disease death. |
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Sociedade Brasileira de Cardiologia - SBC |
publishDate |
2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015000200010 |
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