Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case

Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case

Abstract Visceral leishmaniasis is a systemic disease that is potentially severe and endemic in Brazil. It clinically manifests as fever, weight loss, swelling, hepatosplenomegaly, paleness, and edema. In this study, we discuss a case of a 1-year-old child diagnosed with refractory visceral leishmaniasis after being treated with liposomal amphotericin B in two distinct occasions. Considering the persistent clinical features and weak response to conventional treatment, a combination therapy with liposomal amphotericin B (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate was initiated, and response to treatment was good.

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Main Authors: Gomes,Maria Antonia Ferreira, Medeiros,Lana Lira Cantidio de, Lobo,Fernanda Paula Dantas, Wanderley,Nathália Rayane Silva, Matos,Ana Paula Rodrigues, Jácome,Tácito do Nascimento, Monteiro,Maria Goretti Lins, Luz,Kleber Giovanni
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Medicina Tropical - SBMT 2018
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000300393
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spelling oai:scielo:S0037-868220180003003932018-12-04Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis caseGomes,Maria Antonia FerreiraMedeiros,Lana Lira Cantidio deLobo,Fernanda Paula DantasWanderley,Nathália Rayane SilvaMatos,Ana Paula RodriguesJácome,Tácito do NascimentoMonteiro,Maria Goretti LinsLuz,Kleber Giovanni Visceral leishmaniasis Refractory Treatment Abstract Visceral leishmaniasis is a systemic disease that is potentially severe and endemic in Brazil. It clinically manifests as fever, weight loss, swelling, hepatosplenomegaly, paleness, and edema. In this study, we discuss a case of a 1-year-old child diagnosed with refractory visceral leishmaniasis after being treated with liposomal amphotericin B in two distinct occasions. Considering the persistent clinical features and weak response to conventional treatment, a combination therapy with liposomal amphotericin B (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate was initiated, and response to treatment was good.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.51 n.3 20182018-06-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000300393en10.1590/0037-8682-0398-2017
institution SCIELO
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country Brasil
countrycode BR
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libraryname SciELO
language English
format Digital
author Gomes,Maria Antonia Ferreira
Medeiros,Lana Lira Cantidio de
Lobo,Fernanda Paula Dantas
Wanderley,Nathália Rayane Silva
Matos,Ana Paula Rodrigues
Jácome,Tácito do Nascimento
Monteiro,Maria Goretti Lins
Luz,Kleber Giovanni
spellingShingle Gomes,Maria Antonia Ferreira
Medeiros,Lana Lira Cantidio de
Lobo,Fernanda Paula Dantas
Wanderley,Nathália Rayane Silva
Matos,Ana Paula Rodrigues
Jácome,Tácito do Nascimento
Monteiro,Maria Goretti Lins
Luz,Kleber Giovanni
Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case
author_facet Gomes,Maria Antonia Ferreira
Medeiros,Lana Lira Cantidio de
Lobo,Fernanda Paula Dantas
Wanderley,Nathália Rayane Silva
Matos,Ana Paula Rodrigues
Jácome,Tácito do Nascimento
Monteiro,Maria Goretti Lins
Luz,Kleber Giovanni
author_sort Gomes,Maria Antonia Ferreira
title Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case
title_short Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case
title_full Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case
title_fullStr Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case
title_full_unstemmed Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case
title_sort combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case
description Abstract Visceral leishmaniasis is a systemic disease that is potentially severe and endemic in Brazil. It clinically manifests as fever, weight loss, swelling, hepatosplenomegaly, paleness, and edema. In this study, we discuss a case of a 1-year-old child diagnosed with refractory visceral leishmaniasis after being treated with liposomal amphotericin B in two distinct occasions. Considering the persistent clinical features and weak response to conventional treatment, a combination therapy with liposomal amphotericin B (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate was initiated, and response to treatment was good.
publisher Sociedade Brasileira de Medicina Tropical - SBMT
publishDate 2018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000300393
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