Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil
Abstract INTRODUCTION: HIV and viral hepatitis infections are major causes of chronic disease worldwide and have some similarities with regard to routes of transmission, epidemiology, front barriers faced during access of treatment, and strategies for a global public health response. The objective was to describe the HIV-1 subtypes, viral tropism and single-nucleotide polymorphisms (SNPs) of interleukin 28B (IL28B) from a case series of HIV/viral hepatitis coinfected patients from southern Brazil. METHODS: Clinical and epidemiological data were evaluated by a review of medical records. Periodic blood draws were taken to determine the viral and host characteristics. RESULTS: This study included 38 patients with HIV/HBV or HIV/HCV coinfection; the median age was 49 years. Thirty-seven (97.4%) were on antiretroviral therapy, 32 (84.2%) had an undetectable viral load, a median CD4+ T-cell count of 452 cells/mm3. HIV-1 subtyping showed 47.4 and 31.6% of patients with subtypes C and B, respectively. Analysis of viral co-receptor usage showed a predominance of the R5 variant (64.7%), with no significant difference between the subtypes. Twenty patients with HIV/HCV coinfection were eligible to receive HCV therapy with pegylated-interferon-alpha plus ribavirin, and 10/20 (50%) of them achieved sustained virological response. SNPs of IL28B were evaluated in 93.3% of patients with HIV/HCV coinfection, and 17 (60.7%) presented the CC genotype. CONCLUSIONS: In the present case series, a higher frequency of HIV subtype C was found in coinfected patients. However such findings need to be prospectively evaluated with the inclusion of data from regional multicenter analyses.
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Sociedade Brasileira de Medicina Tropical - SBMT
2017
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oai:scielo:S0037-868220170004004702017-09-13Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern BrazilAvanzi,Valéria MirandaVicente,Bianca ArãoBeloto,Nayara Carvalho PolidoGomes-da-Silva,Monica MariaRibeiro,Clea Elisa LopesTuon,Felipe FranciscoVidal,Luine Rosele RenaudNogueira,Meri BordignonRaboni,Sonia Mara HIV hepatitis C virus hepatitis B virus Coinfection CCR5 IL28B Abstract INTRODUCTION: HIV and viral hepatitis infections are major causes of chronic disease worldwide and have some similarities with regard to routes of transmission, epidemiology, front barriers faced during access of treatment, and strategies for a global public health response. The objective was to describe the HIV-1 subtypes, viral tropism and single-nucleotide polymorphisms (SNPs) of interleukin 28B (IL28B) from a case series of HIV/viral hepatitis coinfected patients from southern Brazil. METHODS: Clinical and epidemiological data were evaluated by a review of medical records. Periodic blood draws were taken to determine the viral and host characteristics. RESULTS: This study included 38 patients with HIV/HBV or HIV/HCV coinfection; the median age was 49 years. Thirty-seven (97.4%) were on antiretroviral therapy, 32 (84.2%) had an undetectable viral load, a median CD4+ T-cell count of 452 cells/mm3. HIV-1 subtyping showed 47.4 and 31.6% of patients with subtypes C and B, respectively. Analysis of viral co-receptor usage showed a predominance of the R5 variant (64.7%), with no significant difference between the subtypes. Twenty patients with HIV/HCV coinfection were eligible to receive HCV therapy with pegylated-interferon-alpha plus ribavirin, and 10/20 (50%) of them achieved sustained virological response. SNPs of IL28B were evaluated in 93.3% of patients with HIV/HCV coinfection, and 17 (60.7%) presented the CC genotype. CONCLUSIONS: In the present case series, a higher frequency of HIV subtype C was found in coinfected patients. However such findings need to be prospectively evaluated with the inclusion of data from regional multicenter analyses.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.50 n.4 20172017-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000400470en10.1590/0037-8682-0450-2016 |
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Avanzi,Valéria Miranda Vicente,Bianca Arão Beloto,Nayara Carvalho Polido Gomes-da-Silva,Monica Maria Ribeiro,Clea Elisa Lopes Tuon,Felipe Francisco Vidal,Luine Rosele Renaud Nogueira,Meri Bordignon Raboni,Sonia Mara |
spellingShingle |
Avanzi,Valéria Miranda Vicente,Bianca Arão Beloto,Nayara Carvalho Polido Gomes-da-Silva,Monica Maria Ribeiro,Clea Elisa Lopes Tuon,Felipe Francisco Vidal,Luine Rosele Renaud Nogueira,Meri Bordignon Raboni,Sonia Mara Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil |
author_facet |
Avanzi,Valéria Miranda Vicente,Bianca Arão Beloto,Nayara Carvalho Polido Gomes-da-Silva,Monica Maria Ribeiro,Clea Elisa Lopes Tuon,Felipe Francisco Vidal,Luine Rosele Renaud Nogueira,Meri Bordignon Raboni,Sonia Mara |
author_sort |
Avanzi,Valéria Miranda |
title |
Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil |
title_short |
Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil |
title_full |
Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil |
title_fullStr |
Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil |
title_full_unstemmed |
Profile of HIV subtypes in HIV/HBV- and HIV/HCV-coinfected patients in Southern Brazil |
title_sort |
profile of hiv subtypes in hiv/hbv- and hiv/hcv-coinfected patients in southern brazil |
description |
Abstract INTRODUCTION: HIV and viral hepatitis infections are major causes of chronic disease worldwide and have some similarities with regard to routes of transmission, epidemiology, front barriers faced during access of treatment, and strategies for a global public health response. The objective was to describe the HIV-1 subtypes, viral tropism and single-nucleotide polymorphisms (SNPs) of interleukin 28B (IL28B) from a case series of HIV/viral hepatitis coinfected patients from southern Brazil. METHODS: Clinical and epidemiological data were evaluated by a review of medical records. Periodic blood draws were taken to determine the viral and host characteristics. RESULTS: This study included 38 patients with HIV/HBV or HIV/HCV coinfection; the median age was 49 years. Thirty-seven (97.4%) were on antiretroviral therapy, 32 (84.2%) had an undetectable viral load, a median CD4+ T-cell count of 452 cells/mm3. HIV-1 subtyping showed 47.4 and 31.6% of patients with subtypes C and B, respectively. Analysis of viral co-receptor usage showed a predominance of the R5 variant (64.7%), with no significant difference between the subtypes. Twenty patients with HIV/HCV coinfection were eligible to receive HCV therapy with pegylated-interferon-alpha plus ribavirin, and 10/20 (50%) of them achieved sustained virological response. SNPs of IL28B were evaluated in 93.3% of patients with HIV/HCV coinfection, and 17 (60.7%) presented the CC genotype. CONCLUSIONS: In the present case series, a higher frequency of HIV subtype C was found in coinfected patients. However such findings need to be prospectively evaluated with the inclusion of data from regional multicenter analyses. |
publisher |
Sociedade Brasileira de Medicina Tropical - SBMT |
publishDate |
2017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000400470 |
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