Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count

We present the case of a 31-year-old man with acute manifestation of progressive multifocal leukoencephalopathy (PML) as an AIDS-defining disease. The patient presented with a three-day history of neurological disease, brain lesions without mass effect or contrast uptake and a slightly increased protein concentration in cerebrospinal fluid. A serological test for HIV was positive and the CD4+ T-cell count was 427/mm³. Histological examination of the brain tissue revealed abnormalities compatible with PML. The disease progressed despite antiretroviral therapy, and the patient died three months later. PML remains an important cause of morbidity and mortality among HIV-infected patients.

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Principais autores:	Silva,Roberta Oliveira de Paula e, Fabiano,Rafaela Cabral Gonçalves, Pedrosa,Moisés Salgado, Lambertucci,José Roberto, Silva,Luciana Cristina dos Santos
Formato:	Digital revista
Idioma:	English
Publicado em:	Sociedade Brasileira de Medicina Tropical - SBMT 2011
Acesso em linha:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000100028
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