Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count

Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count

We present the case of a 31-year-old man with acute manifestation of progressive multifocal leukoencephalopathy (PML) as an AIDS-defining disease. The patient presented with a three-day history of neurological disease, brain lesions without mass effect or contrast uptake and a slightly increased protein concentration in cerebrospinal fluid. A serological test for HIV was positive and the CD4+ T-cell count was 427/mm³. Histological examination of the brain tissue revealed abnormalities compatible with PML. The disease progressed despite antiretroviral therapy, and the patient died three months later. PML remains an important cause of morbidity and mortality among HIV-infected patients.

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Main Authors: Silva,Roberta Oliveira de Paula e, Fabiano,Rafaela Cabral Gonçalves, Pedrosa,Moisés Salgado, Lambertucci,José Roberto, Silva,Luciana Cristina dos Santos
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Medicina Tropical - SBMT 2011
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000100028
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spelling oai:scielo:S0037-868220110001000282011-02-14Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte countSilva,Roberta Oliveira de Paula eFabiano,Rafaela Cabral GonçalvesPedrosa,Moisés SalgadoLambertucci,José RobertoSilva,Luciana Cristina dos Santos Progressive multifocal leukoencephalopathy AIDS HIV CD4+ T-lymphocytes JC virus We present the case of a 31-year-old man with acute manifestation of progressive multifocal leukoencephalopathy (PML) as an AIDS-defining disease. The patient presented with a three-day history of neurological disease, brain lesions without mass effect or contrast uptake and a slightly increased protein concentration in cerebrospinal fluid. A serological test for HIV was positive and the CD4+ T-cell count was 427/mm³. Histological examination of the brain tissue revealed abnormalities compatible with PML. The disease progressed despite antiretroviral therapy, and the patient died three months later. PML remains an important cause of morbidity and mortality among HIV-infected patients.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.44 n.1 20112011-02-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000100028en10.1590/S0037-86822011000100028
institution SCIELO
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country Brasil
countrycode BR
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databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Silva,Roberta Oliveira de Paula e
Fabiano,Rafaela Cabral Gonçalves
Pedrosa,Moisés Salgado
Lambertucci,José Roberto
Silva,Luciana Cristina dos Santos
spellingShingle Silva,Roberta Oliveira de Paula e
Fabiano,Rafaela Cabral Gonçalves
Pedrosa,Moisés Salgado
Lambertucci,José Roberto
Silva,Luciana Cristina dos Santos
Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count
author_facet Silva,Roberta Oliveira de Paula e
Fabiano,Rafaela Cabral Gonçalves
Pedrosa,Moisés Salgado
Lambertucci,José Roberto
Silva,Luciana Cristina dos Santos
author_sort Silva,Roberta Oliveira de Paula e
title Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count
title_short Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count
title_full Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count
title_fullStr Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count
title_full_unstemmed Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count
title_sort progressive multifocal leukoencephalopathy as an aids-defining condition in a patient with high cd4+ t-lymphocyte count
description We present the case of a 31-year-old man with acute manifestation of progressive multifocal leukoencephalopathy (PML) as an AIDS-defining disease. The patient presented with a three-day history of neurological disease, brain lesions without mass effect or contrast uptake and a slightly increased protein concentration in cerebrospinal fluid. A serological test for HIV was positive and the CD4+ T-cell count was 427/mm³. Histological examination of the brain tissue revealed abnormalities compatible with PML. The disease progressed despite antiretroviral therapy, and the patient died three months later. PML remains an important cause of morbidity and mortality among HIV-infected patients.
publisher Sociedade Brasileira de Medicina Tropical - SBMT
publishDate 2011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000100028
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AT fabianorafaelacabralgoncalves progressivemultifocalleukoencephalopathyasanaidsdefiningconditioninapatientwithhighcd4tlymphocytecount
AT pedrosamoisessalgado progressivemultifocalleukoencephalopathyasanaidsdefiningconditioninapatientwithhighcd4tlymphocytecount
AT lambertuccijoseroberto progressivemultifocalleukoencephalopathyasanaidsdefiningconditioninapatientwithhighcd4tlymphocytecount
AT silvalucianacristinadossantos progressivemultifocalleukoencephalopathyasanaidsdefiningconditioninapatientwithhighcd4tlymphocytecount
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