Distribution of hepatitis C virus genotypes among different exposure categories in the State of Pará, Brazilian Amazon
INTRODUCTION: Epidemiological studies concerning HCV genotypic distribution in the Brazilian Amazon are scarce. Thus, this study determined the patterns of distribution of HCV genotypes among different exposure categories in the State of Pará, Brazilian Amazon. METHODS: A cross-sectional study was conducted on 312 HCV-infected individuals belonging to different categories of exposure, who were attended at the HEMOPA, CENPREN and a private hemodialysis clinic in Belém. They were tested for HCV antibodies using an immunoenzymatic test, RNA-HCV, using real-time PCR and HCV genotyping through phylogenetic analysis of the 5' UTR. The population groups were epidemiologically characterized according to data collected in a brief interview or medical consultation. RESULTS: Genotype 1 predominated in all the different categories of HCV exposure. HCV genotypic distribution among blood donors comprised genotypes 1 (94%) and 3 (6%). All patients with chronic hematologic diseases had HCV genotype 1. The genotypic distribution in illicit-drug users comprised genotypes 1 (59.6%) and 3 (40.4%). In patients under hemodialysis, genotypes 1 (90.1%), 2 (3.3%), and 3 (6.6%) were detected. Finally, the frequency of genotypes 1 and 3 was significantly different between the groups: BD and DU, PUH and DU, PUH and PCHD and PCHD and DU. CONCLUSIONS: The genotypic frequency and distribution of HCV in different categories of exposure in the State of Pará showed a predominance of genotype 1, regardless of the possible risk of infection.
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Sociedade Brasileira de Medicina Tropical - SBMT
2011
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oai:scielo:S0037-868220110001000032011-02-14Distribution of hepatitis C virus genotypes among different exposure categories in the State of Pará, Brazilian AmazonSawada,LeilaPinheiro,Andréia Cristina CostaLocks,DaianePimenta,Adriana do Socorro CoelhoRezende,Priscila RochaCrespo,Deborah MaiaCrescente,José Ângelo BarlettaLemos,José Alexandre Rodrigues deOliveira Filho,Aldemir Branco de HCV Genotype Risk group Pará Brazilian Amazon INTRODUCTION: Epidemiological studies concerning HCV genotypic distribution in the Brazilian Amazon are scarce. Thus, this study determined the patterns of distribution of HCV genotypes among different exposure categories in the State of Pará, Brazilian Amazon. METHODS: A cross-sectional study was conducted on 312 HCV-infected individuals belonging to different categories of exposure, who were attended at the HEMOPA, CENPREN and a private hemodialysis clinic in Belém. They were tested for HCV antibodies using an immunoenzymatic test, RNA-HCV, using real-time PCR and HCV genotyping through phylogenetic analysis of the 5' UTR. The population groups were epidemiologically characterized according to data collected in a brief interview or medical consultation. RESULTS: Genotype 1 predominated in all the different categories of HCV exposure. HCV genotypic distribution among blood donors comprised genotypes 1 (94%) and 3 (6%). All patients with chronic hematologic diseases had HCV genotype 1. The genotypic distribution in illicit-drug users comprised genotypes 1 (59.6%) and 3 (40.4%). In patients under hemodialysis, genotypes 1 (90.1%), 2 (3.3%), and 3 (6.6%) were detected. Finally, the frequency of genotypes 1 and 3 was significantly different between the groups: BD and DU, PUH and DU, PUH and PCHD and PCHD and DU. CONCLUSIONS: The genotypic frequency and distribution of HCV in different categories of exposure in the State of Pará showed a predominance of genotype 1, regardless of the possible risk of infection.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.44 n.1 20112011-02-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000100003en10.1590/S0037-86822011000100003 |
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Sawada,Leila Pinheiro,Andréia Cristina Costa Locks,Daiane Pimenta,Adriana do Socorro Coelho Rezende,Priscila Rocha Crespo,Deborah Maia Crescente,José Ângelo Barletta Lemos,José Alexandre Rodrigues de Oliveira Filho,Aldemir Branco de |
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Sawada,Leila Pinheiro,Andréia Cristina Costa Locks,Daiane Pimenta,Adriana do Socorro Coelho Rezende,Priscila Rocha Crespo,Deborah Maia Crescente,José Ângelo Barletta Lemos,José Alexandre Rodrigues de Oliveira Filho,Aldemir Branco de Distribution of hepatitis C virus genotypes among different exposure categories in the State of Pará, Brazilian Amazon |
author_facet |
Sawada,Leila Pinheiro,Andréia Cristina Costa Locks,Daiane Pimenta,Adriana do Socorro Coelho Rezende,Priscila Rocha Crespo,Deborah Maia Crescente,José Ângelo Barletta Lemos,José Alexandre Rodrigues de Oliveira Filho,Aldemir Branco de |
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Sawada,Leila |
title |
Distribution of hepatitis C virus genotypes among different exposure categories in the State of Pará, Brazilian Amazon |
title_short |
Distribution of hepatitis C virus genotypes among different exposure categories in the State of Pará, Brazilian Amazon |
title_full |
Distribution of hepatitis C virus genotypes among different exposure categories in the State of Pará, Brazilian Amazon |
title_fullStr |
Distribution of hepatitis C virus genotypes among different exposure categories in the State of Pará, Brazilian Amazon |
title_full_unstemmed |
Distribution of hepatitis C virus genotypes among different exposure categories in the State of Pará, Brazilian Amazon |
title_sort |
distribution of hepatitis c virus genotypes among different exposure categories in the state of pará, brazilian amazon |
description |
INTRODUCTION: Epidemiological studies concerning HCV genotypic distribution in the Brazilian Amazon are scarce. Thus, this study determined the patterns of distribution of HCV genotypes among different exposure categories in the State of Pará, Brazilian Amazon. METHODS: A cross-sectional study was conducted on 312 HCV-infected individuals belonging to different categories of exposure, who were attended at the HEMOPA, CENPREN and a private hemodialysis clinic in Belém. They were tested for HCV antibodies using an immunoenzymatic test, RNA-HCV, using real-time PCR and HCV genotyping through phylogenetic analysis of the 5' UTR. The population groups were epidemiologically characterized according to data collected in a brief interview or medical consultation. RESULTS: Genotype 1 predominated in all the different categories of HCV exposure. HCV genotypic distribution among blood donors comprised genotypes 1 (94%) and 3 (6%). All patients with chronic hematologic diseases had HCV genotype 1. The genotypic distribution in illicit-drug users comprised genotypes 1 (59.6%) and 3 (40.4%). In patients under hemodialysis, genotypes 1 (90.1%), 2 (3.3%), and 3 (6.6%) were detected. Finally, the frequency of genotypes 1 and 3 was significantly different between the groups: BD and DU, PUH and DU, PUH and PCHD and PCHD and DU. CONCLUSIONS: The genotypic frequency and distribution of HCV in different categories of exposure in the State of Pará showed a predominance of genotype 1, regardless of the possible risk of infection. |
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Sociedade Brasileira de Medicina Tropical - SBMT |
publishDate |
2011 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822011000100003 |
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