Hospital-acquired intestinal toxemia botulism in a newly diagnosed adult colon cancer patient
ABSTRACT This manuscript reports a case of intestinal toxemia botulism in an adult with recently diagnosed metastatic colon cancer in whom botulism symptoms began 23 days after hospital admission. Representing the rarest form of botulism presentation in clinical practice, this infectious disease may have developed due to a cluster of predisposing factors that favored Clostridium botulinum colonization and the endogenous production of neurotoxins, among which are previous use of broad-spectrum antibiotics and colon changes related to the development of the neoplasia. This case highlights the importance of considering intestinal toxemia botulism in the differential diagnosis of a patient presenting with symmetrical descending flaccid paralysis, since immediate treatment with botulinum antitoxin may improve clinical outcomes.
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Instituto de Medicina Tropical de São Paulo
2019
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oai:scielo:S0036-466520190050005062019-11-19Hospital-acquired intestinal toxemia botulism in a newly diagnosed adult colon cancer patientFonseca,Lucas José Sá daCarvalho,Diogo Couto deMoraes,Helena Providelli deFeitosa,Izabela Dayany FrançaPereira Neto,GilVilela,Rodrigo VasconcellosFernandes,Breno Franco SilveiraGomez,Rodrigo SantiagoNobre,Vandack Adult intestinal toxemia botulism Neuropathy Intestinal colonization Diagnosis Neuromuscular junction Symmetrical descending flaccid paralysis Clostridium botulinum ABSTRACT This manuscript reports a case of intestinal toxemia botulism in an adult with recently diagnosed metastatic colon cancer in whom botulism symptoms began 23 days after hospital admission. Representing the rarest form of botulism presentation in clinical practice, this infectious disease may have developed due to a cluster of predisposing factors that favored Clostridium botulinum colonization and the endogenous production of neurotoxins, among which are previous use of broad-spectrum antibiotics and colon changes related to the development of the neoplasia. This case highlights the importance of considering intestinal toxemia botulism in the differential diagnosis of a patient presenting with symmetrical descending flaccid paralysis, since immediate treatment with botulinum antitoxin may improve clinical outcomes.info:eu-repo/semantics/openAccessInstituto de Medicina Tropical de São PauloRevista do Instituto de Medicina Tropical de São Paulo v.61 20192019-01-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652019005000506en10.1590/s1678-9946201961049 |
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Fonseca,Lucas José Sá da Carvalho,Diogo Couto de Moraes,Helena Providelli de Feitosa,Izabela Dayany França Pereira Neto,Gil Vilela,Rodrigo Vasconcellos Fernandes,Breno Franco Silveira Gomez,Rodrigo Santiago Nobre,Vandack |
| spellingShingle |
Fonseca,Lucas José Sá da Carvalho,Diogo Couto de Moraes,Helena Providelli de Feitosa,Izabela Dayany França Pereira Neto,Gil Vilela,Rodrigo Vasconcellos Fernandes,Breno Franco Silveira Gomez,Rodrigo Santiago Nobre,Vandack Hospital-acquired intestinal toxemia botulism in a newly diagnosed adult colon cancer patient |
| author_facet |
Fonseca,Lucas José Sá da Carvalho,Diogo Couto de Moraes,Helena Providelli de Feitosa,Izabela Dayany França Pereira Neto,Gil Vilela,Rodrigo Vasconcellos Fernandes,Breno Franco Silveira Gomez,Rodrigo Santiago Nobre,Vandack |
| author_sort |
Fonseca,Lucas José Sá da |
| title |
Hospital-acquired intestinal toxemia botulism in a newly diagnosed adult colon cancer patient |
| title_short |
Hospital-acquired intestinal toxemia botulism in a newly diagnosed adult colon cancer patient |
| title_full |
Hospital-acquired intestinal toxemia botulism in a newly diagnosed adult colon cancer patient |
| title_fullStr |
Hospital-acquired intestinal toxemia botulism in a newly diagnosed adult colon cancer patient |
| title_full_unstemmed |
Hospital-acquired intestinal toxemia botulism in a newly diagnosed adult colon cancer patient |
| title_sort |
hospital-acquired intestinal toxemia botulism in a newly diagnosed adult colon cancer patient |
| description |
ABSTRACT This manuscript reports a case of intestinal toxemia botulism in an adult with recently diagnosed metastatic colon cancer in whom botulism symptoms began 23 days after hospital admission. Representing the rarest form of botulism presentation in clinical practice, this infectious disease may have developed due to a cluster of predisposing factors that favored Clostridium botulinum colonization and the endogenous production of neurotoxins, among which are previous use of broad-spectrum antibiotics and colon changes related to the development of the neoplasia. This case highlights the importance of considering intestinal toxemia botulism in the differential diagnosis of a patient presenting with symmetrical descending flaccid paralysis, since immediate treatment with botulinum antitoxin may improve clinical outcomes. |
| publisher |
Instituto de Medicina Tropical de São Paulo |
| publishDate |
2019 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652019005000506 |
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