Legionnaires' disease in the renal transplant unit of "Hospital das Clinicas, FMUSP": during a five year period (1988-1993)

Legionnaires' disease in the renal transplant unit of "Hospital das Clinicas, FMUSP": during a five year period (1988-1993)

Several reports have related Legionella pneumophila with pneumonia in renal transplant patients, however this association has not been systematically documented in Brazil. Therefore this paper reports the incidence, by serologycal assays, of Legionella pneumophila serogroup 1 in these patients during a five year period. For this purpose sera from blood samples of 70 hospitalized patients with pneumonia from the Renal Transplant Unit of Hospital das Clinicas, FMUSP collected at the acute and convalescent phase of infection were submitted to indirect immunofluorescence assay (IFA) to demonstrate anti-Legionella pneumophila serogroup 1 antibodies. Of these 70 patients studied during the period of 1988 to 1993,18 (25.71 %) had significant rises in specific antibody titers for Legionella pneumophila serogroup 1. Incidence was interrupted following Hospital water decontamination procedures, with recurrence of infections after treatment interruption. In this study, the high susceptibility (25.71%) of immunodepressed renal transplant patients to Legionella pneumophila serogroup 1 nosocomial infections is documented. The importance of the implementation and maintenance of water decontamination measures for prophylaxis of the infection is also clearly evident.

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Main Authors: Mazieri,Neusa Augusta de Oliveira, Godoy,Cid Vieira Franco de, Alves,Solange Figueiredo, Andrade,Dahir Ramos de, Levin,Ana Sara S., Hablitzel,Ana Cristina
Format: Digital revista
Language:English
Published: Instituto de Medicina Tropical de São Paulo 1994
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651994000300007
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spelling oai:scielo:S0036-466519940003000072006-09-20Legionnaires' disease in the renal transplant unit of "Hospital das Clinicas, FMUSP": during a five year period (1988-1993)Mazieri,Neusa Augusta de OliveiraGodoy,Cid Vieira Franco deAlves,Solange FigueiredoAndrade,Dahir Ramos deLevin,Ana Sara S.Hablitzel,Ana Cristina Legionnaires' disease Renal transplant unit Several reports have related Legionella pneumophila with pneumonia in renal transplant patients, however this association has not been systematically documented in Brazil. Therefore this paper reports the incidence, by serologycal assays, of Legionella pneumophila serogroup 1 in these patients during a five year period. For this purpose sera from blood samples of 70 hospitalized patients with pneumonia from the Renal Transplant Unit of Hospital das Clinicas, FMUSP collected at the acute and convalescent phase of infection were submitted to indirect immunofluorescence assay (IFA) to demonstrate anti-Legionella pneumophila serogroup 1 antibodies. Of these 70 patients studied during the period of 1988 to 1993,18 (25.71 %) had significant rises in specific antibody titers for Legionella pneumophila serogroup 1. Incidence was interrupted following Hospital water decontamination procedures, with recurrence of infections after treatment interruption. In this study, the high susceptibility (25.71%) of immunodepressed renal transplant patients to Legionella pneumophila serogroup 1 nosocomial infections is documented. The importance of the implementation and maintenance of water decontamination measures for prophylaxis of the infection is also clearly evident.info:eu-repo/semantics/openAccessInstituto de Medicina Tropical de São PauloRevista do Instituto de Medicina Tropical de São Paulo v.36 n.3 19941994-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651994000300007en10.1590/S0036-46651994000300007
institution SCIELO
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country Brasil
countrycode BR
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databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Mazieri,Neusa Augusta de Oliveira
Godoy,Cid Vieira Franco de
Alves,Solange Figueiredo
Andrade,Dahir Ramos de
Levin,Ana Sara S.
Hablitzel,Ana Cristina
spellingShingle Mazieri,Neusa Augusta de Oliveira
Godoy,Cid Vieira Franco de
Alves,Solange Figueiredo
Andrade,Dahir Ramos de
Levin,Ana Sara S.
Hablitzel,Ana Cristina
Legionnaires' disease in the renal transplant unit of "Hospital das Clinicas, FMUSP": during a five year period (1988-1993)
author_facet Mazieri,Neusa Augusta de Oliveira
Godoy,Cid Vieira Franco de
Alves,Solange Figueiredo
Andrade,Dahir Ramos de
Levin,Ana Sara S.
Hablitzel,Ana Cristina
author_sort Mazieri,Neusa Augusta de Oliveira
title Legionnaires' disease in the renal transplant unit of "Hospital das Clinicas, FMUSP": during a five year period (1988-1993)
title_short Legionnaires' disease in the renal transplant unit of "Hospital das Clinicas, FMUSP": during a five year period (1988-1993)
title_full Legionnaires' disease in the renal transplant unit of "Hospital das Clinicas, FMUSP": during a five year period (1988-1993)
title_fullStr Legionnaires' disease in the renal transplant unit of "Hospital das Clinicas, FMUSP": during a five year period (1988-1993)
title_full_unstemmed Legionnaires' disease in the renal transplant unit of "Hospital das Clinicas, FMUSP": during a five year period (1988-1993)
title_sort legionnaires' disease in the renal transplant unit of "hospital das clinicas, fmusp": during a five year period (1988-1993)
description Several reports have related Legionella pneumophila with pneumonia in renal transplant patients, however this association has not been systematically documented in Brazil. Therefore this paper reports the incidence, by serologycal assays, of Legionella pneumophila serogroup 1 in these patients during a five year period. For this purpose sera from blood samples of 70 hospitalized patients with pneumonia from the Renal Transplant Unit of Hospital das Clinicas, FMUSP collected at the acute and convalescent phase of infection were submitted to indirect immunofluorescence assay (IFA) to demonstrate anti-Legionella pneumophila serogroup 1 antibodies. Of these 70 patients studied during the period of 1988 to 1993,18 (25.71 %) had significant rises in specific antibody titers for Legionella pneumophila serogroup 1. Incidence was interrupted following Hospital water decontamination procedures, with recurrence of infections after treatment interruption. In this study, the high susceptibility (25.71%) of immunodepressed renal transplant patients to Legionella pneumophila serogroup 1 nosocomial infections is documented. The importance of the implementation and maintenance of water decontamination measures for prophylaxis of the infection is also clearly evident.
publisher Instituto de Medicina Tropical de São Paulo
publishDate 1994
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651994000300007
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