Galectina-3: experiencia en pacientes chilenos con diagnóstico de insuficiencia cardíaca descompensada
Background: Galectin-3 (Gal-3) is a mediator of myocardial fibrosis involved in cardiac remodeling and a potential new prognosis marker in heart failure (HF). Aim: To measure Gal-3 at the moment of discharge in patients hospitalized for HF and its association with different variables. Material and Methods: Patients hospitalized for decompensated HF from four hospitals between August 2014 and March 2015, were included. Demographic, clinical and laboratory variables were recorded at the time of admission. At discharge, a blood sample was withdrawn to measure Gal-3 and brain natriuretic propeptide (Pro-BNP). Patients were separated in two groups, according to the level of Gal-3 (using a cutoff value of 17.8 ng/mL), comparing clinical and laboratory values between groups. Results: We included 52 patients with HF aged 70 ± 17 years (42% females). Functional capacity was III-IV in 46% of patients and the ejection fraction was 34.9 ± 13.4%. Pro-BNP values at discharge were 5,323 ± 8,665 pg/mL. Gal-3 values were 23.8 ± 16.6 ng/mL. Sixty percent of patients had values over 17.8 ng/mL. Those with elevated Gal-3 levels were older (75 ±16 and 62 ± 15 years, respectively, p = 0.025) and were hypertensive in a higher proportion (90.5% and 57.1% respectively, p = 0.021). Conclusions: In patients hospitalized for HF, Gal-3 levels are higher in older and hypertensive subjects.
Principais autores: | Rossel,Víctor, Díaz-Toro,Felipe, Verdejo,Hugo, Concepción,Roberto, Sepúlveda,Luis, Castro,Pablo, Vukasovic,José Luis, Bernales,Angie |
---|---|
Formato: | Digital revista |
Idioma: | Spanish / Castilian |
Publicado em: |
Sociedad Médica de Santiago
2017
|
Acesso em linha: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872017000600734 |
Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
Registros relacionados
-
Factores asociados a fragilidad en pacientes hospitalizados con insuficiencia cardiaca descompensada
por: Díaz-Toro,Felipe, et al.
Publicado em: (2017) -
Insuficiência cardíaca descompensada
por: Mangini,Sandrigo, et al.
Publicado em: (2013) -
Insuficiencia cardíaca aguda e insuficiencia cardíaca descompensada
por: Arias Mendoza,María Alexandra, et al.
Publicado em: (2007) -
Tratamento atual da insuficiência cardíaca descompensada
por: Vilas-Boas,Fábio, et al.
Publicado em: (2006) -
Insuficiencia cardíaca aguda descompensada: un enfoque actualizado
por: Speranza,Mario O
Publicado em: (2005)