Prevalence of chronic obstructive pulmonary disease in patients diagnosed with HIV without prior antiretroviral treatment

Abstract Introduction: Chronic obstructive pulmonary disease (COPD) is the most prevalent respiratory problem in the world. Patients with human immunodeficiency virus (HIV) infection have a higher prevalence of smoking and recurrent lung infections and are at higher risk of COPD. Objective: To determine the prevalence of COPD in HIV-diagnosed patients referred to an infectious diseases hospital. Method: Individuals with HIV infection without previous or ongoing antiretroviral treatment, with chronic respiratory symptoms, with or without a history of exposure for the development of COPD were included. Pre- and post-bronchodilation spirometry, high-resolution computed tomography, viral load determination and CD4 count were carried out. Spirometry measurements were compared with Wilcoxon’s test. Results: Sixty-six HIV-diagnosed patients, with a mean age of 31.5 years were included; 64 were males and two females. The prevalence of COPD was 7.6 %. The group with obstruction had a lower CD4 count (27.3 versus 225.9) and higher viral load (165,000 versus 57,722), in comparison with the group without obstruction. A positive correlation was observed between lower viral load and higher forced expiratory volume in 1 second/forced vital capacity ratio. Conclusion: HIV-positive patients with a lower CD4 count and a higher viral load show a decrease in spirometry values.

Bibliographic Details

Main Authors:	Romero-López,Zaira, Rojas-Cisneros,Fermín Alejandro, Ochoa-Vázquez,María Dolores, Rico-Méndez,Favio Gerardo, Mata-Marín,José Antonio
Format:	Digital revista
Language:	English
Published:	Academia Nacional de Medicina de México A.C. 2020
Online Access:	http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0016-38132020000400283
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