Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel
Abstract Particulate matter (PM) less than 2.5 um emitted by diesel engines is responsible for the morbidity and mortality associated with air pollution. Alternative fuels have been implemented, but their potential toxic effects are still unknown. The objective of this article is to evaluate the in vitro toxicity of the organic extract of particulate matter emitted by a diesel engine powered by two different fuels. Following cell exposure to fossil diesel + 10% ethanol and fossil diesel extracts, mutagenicity, genotoxicity, and differential gene expression were evaluated. The results showed that the organic extracts of diesel PM + 10% ethanol were more biotoxic (p<0.05). More studies are needed to better understand the health effect of PM emissions from biofuel.
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Universidad Nacional de Colombia
2022
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oai:scielo:S0012-735320220002001102022-09-20Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of dieselOrozco-Jiménez,Luz YanethEstrada-Vélez,VerónicaCuesta-Castro,Diana PaolaIsaza,Juan PabloMolina,FranciscoPalacio-B,JaimeÁlvarez-Orozco,Maria ElenaOrtiz-Trujillo,Isabel diesel particulate matter organic extraction genotoxicity mutagenicity transcriptomics Abstract Particulate matter (PM) less than 2.5 um emitted by diesel engines is responsible for the morbidity and mortality associated with air pollution. Alternative fuels have been implemented, but their potential toxic effects are still unknown. The objective of this article is to evaluate the in vitro toxicity of the organic extract of particulate matter emitted by a diesel engine powered by two different fuels. Following cell exposure to fossil diesel + 10% ethanol and fossil diesel extracts, mutagenicity, genotoxicity, and differential gene expression were evaluated. The results showed that the organic extracts of diesel PM + 10% ethanol were more biotoxic (p<0.05). More studies are needed to better understand the health effect of PM emissions from biofuel.info:eu-repo/semantics/openAccessUniversidad Nacional de ColombiaDYNA v.89 n.221 20222022-06-01info:eu-repo/semantics/articletext/htmlhttp://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0012-73532022000200110en10.15446/dyna.v89n221.99394 |
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Orozco-Jiménez,Luz Yaneth Estrada-Vélez,Verónica Cuesta-Castro,Diana Paola Isaza,Juan Pablo Molina,Francisco Palacio-B,Jaime Álvarez-Orozco,Maria Elena Ortiz-Trujillo,Isabel |
| spellingShingle |
Orozco-Jiménez,Luz Yaneth Estrada-Vélez,Verónica Cuesta-Castro,Diana Paola Isaza,Juan Pablo Molina,Francisco Palacio-B,Jaime Álvarez-Orozco,Maria Elena Ortiz-Trujillo,Isabel Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel |
| author_facet |
Orozco-Jiménez,Luz Yaneth Estrada-Vélez,Verónica Cuesta-Castro,Diana Paola Isaza,Juan Pablo Molina,Francisco Palacio-B,Jaime Álvarez-Orozco,Maria Elena Ortiz-Trujillo,Isabel |
| author_sort |
Orozco-Jiménez,Luz Yaneth |
| title |
Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel |
| title_short |
Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel |
| title_full |
Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel |
| title_fullStr |
Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel |
| title_full_unstemmed |
Alteration in the gene expression of the HepG2 cell line by exposure to particulate matter (PM) of diesel |
| title_sort |
alteration in the gene expression of the hepg2 cell line by exposure to particulate matter (pm) of diesel |
| description |
Abstract Particulate matter (PM) less than 2.5 um emitted by diesel engines is responsible for the morbidity and mortality associated with air pollution. Alternative fuels have been implemented, but their potential toxic effects are still unknown. The objective of this article is to evaluate the in vitro toxicity of the organic extract of particulate matter emitted by a diesel engine powered by two different fuels. Following cell exposure to fossil diesel + 10% ethanol and fossil diesel extracts, mutagenicity, genotoxicity, and differential gene expression were evaluated. The results showed that the organic extracts of diesel PM + 10% ethanol were more biotoxic (p<0.05). More studies are needed to better understand the health effect of PM emissions from biofuel. |
| publisher |
Universidad Nacional de Colombia |
| publishDate |
2022 |
| url |
http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0012-73532022000200110 |
| work_keys_str_mv |
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