Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study
ABSTRACT Background: Intrinsic changes in Parkinson's disease (PD) affect the autonomic nervous system, and the disease course can aggravate the initial condition. Although the impact of time since disease onset on autonomic modulation has already been studied in other populations, this has not yet been investigated in PD. Objective: To investigate the impact of the length of time since diagnosis on the cardiac autonomic modulation of individuals with PD and compare with healthy individuals. Methods: Fifty participants were divided into three groups: a control group (CG; n = 24) and two groups with PD, divided according to the median length of time since diagnosis (median = 5.5 years): below the median (PG1; n = 13) and above the median (PG2; n = 13). To evaluate cardiac autonomic modulation, heart rate was obtained beat-to-beat in the supine position over a 30-min period, and heart rate variability (HRV) indices were calculated using linear methods in the time and frequency domains. Results: There were no significant differences in HRV indices between the PG groups, or between the three groups regarding Mean RR, LFun, HFun and LF/HF ratio. Significant reductions in the RMSSD, SDNN, pNN50, LFms2 and HFms2 indices were observed in PG1 and PG2, compared with CG. Conclusions: The cardiac autonomic modulation of individuals with PD was not influenced by the time since diagnosis. However, reduced parasympathetic and global modulation were observed in these individuals, compared with controls. These results emphasize the importance of aerobic exercise for improving autonomic modulation among individuals with PD.
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Academia Brasileira de Neurologia - ABNEURO
2022
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oai:scielo:S0004-282X20220006005932022-08-09Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional studyStoco-Oliveira,Mileide CristinaValente,Heloisa BalotariVanzella,Laís ManataAndré,Larissa BorbaRodrigues,Mariana VianaVanderlei,Franciele MarquesCarvalho,Augusto Cesinando deVanderlei,Luiz Carlos Marques Parkinson Disease Autonomic Nervous System Diseases Neurodegenerative Diseases ABSTRACT Background: Intrinsic changes in Parkinson's disease (PD) affect the autonomic nervous system, and the disease course can aggravate the initial condition. Although the impact of time since disease onset on autonomic modulation has already been studied in other populations, this has not yet been investigated in PD. Objective: To investigate the impact of the length of time since diagnosis on the cardiac autonomic modulation of individuals with PD and compare with healthy individuals. Methods: Fifty participants were divided into three groups: a control group (CG; n = 24) and two groups with PD, divided according to the median length of time since diagnosis (median = 5.5 years): below the median (PG1; n = 13) and above the median (PG2; n = 13). To evaluate cardiac autonomic modulation, heart rate was obtained beat-to-beat in the supine position over a 30-min period, and heart rate variability (HRV) indices were calculated using linear methods in the time and frequency domains. Results: There were no significant differences in HRV indices between the PG groups, or between the three groups regarding Mean RR, LFun, HFun and LF/HF ratio. Significant reductions in the RMSSD, SDNN, pNN50, LFms2 and HFms2 indices were observed in PG1 and PG2, compared with CG. Conclusions: The cardiac autonomic modulation of individuals with PD was not influenced by the time since diagnosis. However, reduced parasympathetic and global modulation were observed in these individuals, compared with controls. These results emphasize the importance of aerobic exercise for improving autonomic modulation among individuals with PD.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.80 n.6 20222022-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000600593en10.1590/0004-282x-anp-2021-0153 |
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Stoco-Oliveira,Mileide Cristina Valente,Heloisa Balotari Vanzella,Laís Manata André,Larissa Borba Rodrigues,Mariana Viana Vanderlei,Franciele Marques Carvalho,Augusto Cesinando de Vanderlei,Luiz Carlos Marques |
spellingShingle |
Stoco-Oliveira,Mileide Cristina Valente,Heloisa Balotari Vanzella,Laís Manata André,Larissa Borba Rodrigues,Mariana Viana Vanderlei,Franciele Marques Carvalho,Augusto Cesinando de Vanderlei,Luiz Carlos Marques Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
author_facet |
Stoco-Oliveira,Mileide Cristina Valente,Heloisa Balotari Vanzella,Laís Manata André,Larissa Borba Rodrigues,Mariana Viana Vanderlei,Franciele Marques Carvalho,Augusto Cesinando de Vanderlei,Luiz Carlos Marques |
author_sort |
Stoco-Oliveira,Mileide Cristina |
title |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_short |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_full |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_fullStr |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_full_unstemmed |
Does length of time since diagnosis in Parkinson’s disease influence heart rate variability? A cross-sectional study |
title_sort |
does length of time since diagnosis in parkinson’s disease influence heart rate variability? a cross-sectional study |
description |
ABSTRACT Background: Intrinsic changes in Parkinson's disease (PD) affect the autonomic nervous system, and the disease course can aggravate the initial condition. Although the impact of time since disease onset on autonomic modulation has already been studied in other populations, this has not yet been investigated in PD. Objective: To investigate the impact of the length of time since diagnosis on the cardiac autonomic modulation of individuals with PD and compare with healthy individuals. Methods: Fifty participants were divided into three groups: a control group (CG; n = 24) and two groups with PD, divided according to the median length of time since diagnosis (median = 5.5 years): below the median (PG1; n = 13) and above the median (PG2; n = 13). To evaluate cardiac autonomic modulation, heart rate was obtained beat-to-beat in the supine position over a 30-min period, and heart rate variability (HRV) indices were calculated using linear methods in the time and frequency domains. Results: There were no significant differences in HRV indices between the PG groups, or between the three groups regarding Mean RR, LFun, HFun and LF/HF ratio. Significant reductions in the RMSSD, SDNN, pNN50, LFms2 and HFms2 indices were observed in PG1 and PG2, compared with CG. Conclusions: The cardiac autonomic modulation of individuals with PD was not influenced by the time since diagnosis. However, reduced parasympathetic and global modulation were observed in these individuals, compared with controls. These results emphasize the importance of aerobic exercise for improving autonomic modulation among individuals with PD. |
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Academia Brasileira de Neurologia - ABNEURO |
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2022 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000600593 |
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