Gut microbiome in neuropsychiatric disorders
ABSTRACT Background: Neuropsychiatric disorders are a significant cause of death and disability worldwide. The mechanisms underlying these disorders include a constellation of structural, infectious, immunological, metabolic, and genetic etiologies. Advances in next-generation sequencing techniques have demonstrated that the composition of the enteric microbiome is dynamic and plays a pivotal role in host homeostasis and several diseases. The enteric microbiome acts as a key mediator in neuronal signaling via metabolic, neuroimmune, and neuroendocrine pathways. Objective: In this review, we aim to present and discuss the most current knowledge regarding the putative influence of the gut microbiome in neuropsychiatric disorders. Methods: We examined some of the preclinical and clinical evidence and therapeutic strategies associated with the manipulation of the gut microbiome. Results: targeted taxa were described and grouped from major studies to each disease. Conclusions: Understanding the complexity of these ecological interactions and their association with susceptibility and progression of acute and chronic disorders could lead to novel diagnostic biomarkers based on molecular targets. Moreover, research on the microbiome can also improve some emerging treatment choices, such as fecal transplantation, personalized probiotics, and dietary interventions, which could be used to reduce the impact of specific neuropsychiatric disorders. We expect that this knowledge will help physicians caring for patients with neuropsychiatric disorders.
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2022
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oai:scielo:S0004-282X20220002001922022-03-22Gut microbiome in neuropsychiatric disordersMEJÍA-GRANADOS,Diana MarcelaVILLASANA-SALAZAR,BenjamínCOAN,Ana CarolinaRIZZI,LiaraBALTHAZAR,Marcio Luiz FigueredoGODOI,Alexandre Barcia deCANTO,Amanda Morato doROSA,Douglas Cescon daSILVA,Lucas ScárduaTACLA,Rafaella do RosarioDAMASCENO,AlfredoDONATTI,AmandaAVELAR,Wagner MauadSOUSA,AlessandroLOPES-CENDES,Iscia Gastrointestinal Microbiome Metagenomics Nervous System Diseases Transplantation Precision Medicine ABSTRACT Background: Neuropsychiatric disorders are a significant cause of death and disability worldwide. The mechanisms underlying these disorders include a constellation of structural, infectious, immunological, metabolic, and genetic etiologies. Advances in next-generation sequencing techniques have demonstrated that the composition of the enteric microbiome is dynamic and plays a pivotal role in host homeostasis and several diseases. The enteric microbiome acts as a key mediator in neuronal signaling via metabolic, neuroimmune, and neuroendocrine pathways. Objective: In this review, we aim to present and discuss the most current knowledge regarding the putative influence of the gut microbiome in neuropsychiatric disorders. Methods: We examined some of the preclinical and clinical evidence and therapeutic strategies associated with the manipulation of the gut microbiome. Results: targeted taxa were described and grouped from major studies to each disease. Conclusions: Understanding the complexity of these ecological interactions and their association with susceptibility and progression of acute and chronic disorders could lead to novel diagnostic biomarkers based on molecular targets. Moreover, research on the microbiome can also improve some emerging treatment choices, such as fecal transplantation, personalized probiotics, and dietary interventions, which could be used to reduce the impact of specific neuropsychiatric disorders. We expect that this knowledge will help physicians caring for patients with neuropsychiatric disorders.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.80 n.2 20222022-02-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000200192en10.1590/0004-282x-anp-2021-0052 |
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MEJÍA-GRANADOS,Diana Marcela VILLASANA-SALAZAR,Benjamín COAN,Ana Carolina RIZZI,Liara BALTHAZAR,Marcio Luiz Figueredo GODOI,Alexandre Barcia de CANTO,Amanda Morato do ROSA,Douglas Cescon da SILVA,Lucas Scárdua TACLA,Rafaella do Rosario DAMASCENO,Alfredo DONATTI,Amanda AVELAR,Wagner Mauad SOUSA,Alessandro LOPES-CENDES,Iscia |
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MEJÍA-GRANADOS,Diana Marcela VILLASANA-SALAZAR,Benjamín COAN,Ana Carolina RIZZI,Liara BALTHAZAR,Marcio Luiz Figueredo GODOI,Alexandre Barcia de CANTO,Amanda Morato do ROSA,Douglas Cescon da SILVA,Lucas Scárdua TACLA,Rafaella do Rosario DAMASCENO,Alfredo DONATTI,Amanda AVELAR,Wagner Mauad SOUSA,Alessandro LOPES-CENDES,Iscia Gut microbiome in neuropsychiatric disorders |
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MEJÍA-GRANADOS,Diana Marcela VILLASANA-SALAZAR,Benjamín COAN,Ana Carolina RIZZI,Liara BALTHAZAR,Marcio Luiz Figueredo GODOI,Alexandre Barcia de CANTO,Amanda Morato do ROSA,Douglas Cescon da SILVA,Lucas Scárdua TACLA,Rafaella do Rosario DAMASCENO,Alfredo DONATTI,Amanda AVELAR,Wagner Mauad SOUSA,Alessandro LOPES-CENDES,Iscia |
author_sort |
MEJÍA-GRANADOS,Diana Marcela |
title |
Gut microbiome in neuropsychiatric disorders |
title_short |
Gut microbiome in neuropsychiatric disorders |
title_full |
Gut microbiome in neuropsychiatric disorders |
title_fullStr |
Gut microbiome in neuropsychiatric disorders |
title_full_unstemmed |
Gut microbiome in neuropsychiatric disorders |
title_sort |
gut microbiome in neuropsychiatric disorders |
description |
ABSTRACT Background: Neuropsychiatric disorders are a significant cause of death and disability worldwide. The mechanisms underlying these disorders include a constellation of structural, infectious, immunological, metabolic, and genetic etiologies. Advances in next-generation sequencing techniques have demonstrated that the composition of the enteric microbiome is dynamic and plays a pivotal role in host homeostasis and several diseases. The enteric microbiome acts as a key mediator in neuronal signaling via metabolic, neuroimmune, and neuroendocrine pathways. Objective: In this review, we aim to present and discuss the most current knowledge regarding the putative influence of the gut microbiome in neuropsychiatric disorders. Methods: We examined some of the preclinical and clinical evidence and therapeutic strategies associated with the manipulation of the gut microbiome. Results: targeted taxa were described and grouped from major studies to each disease. Conclusions: Understanding the complexity of these ecological interactions and their association with susceptibility and progression of acute and chronic disorders could lead to novel diagnostic biomarkers based on molecular targets. Moreover, research on the microbiome can also improve some emerging treatment choices, such as fecal transplantation, personalized probiotics, and dietary interventions, which could be used to reduce the impact of specific neuropsychiatric disorders. We expect that this knowledge will help physicians caring for patients with neuropsychiatric disorders. |
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Academia Brasileira de Neurologia - ABNEURO |
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2022 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000200192 |
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