Grade I meningiomas with atypical characteristics: a worse prognosis

ABSTRACT The study reviewed the histology of cases of grade I meningiomas with spontaneous necrosis, grade I without necrosis and grade II meningiomas, to evaluate the histological and immunohistochemical factors of the patients’ prognosis, while correlating the clinicopathological features with the clinical follow-up of the patients. A review of 47 cases from the Department of Pathology of UNIFESP was performed and the samples were submitted to immunohistochemical examination with the p53 protein, Ki-67 cell proliferation factor and progesterone receptor markers. A greater expression was found in the progression of several degrees of aggressiveness for p53 and Ki-67, and a higher frequency of progesterone receptors in the lower degrees. The group of grade I meningiomas with spontaneous necrosis showed histological and immunohistochemical indexes that approximate those of the grade II meningioma. This suggests a worse prognosis for grade I meningiomas with necrosis.

Bibliographic Details

Main Authors:	Marcos,Débora S., Paiva Neto,Manoel A., Góes,Pedro, Oshima,Celina T. F., Silva,Marcelo S., Stávale,João N.
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Neurologia - ABNEURO 2018
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018001100756
Tags:	Add Tag No Tags, Be the first to tag this record!