The role of vagus nerve stimulation in refractory epilepsy
ABSTRACT Vagus nerve stimulation is an adjunctive therapy used to treat patients with refractory epilepsy who are not candidates for resective surgery or had poor results after surgical procedures. Its mechanism of action is not yet fully comprehended but it possibly involves modulation of the locus coeruleus, thalamus and limbic circuit through noradrenergic and serotonergic projections. There is sufficient evidence to support its use in patients with focal epilepsy and other seizure types. However, it should be recognized that improvement is not immediate and increases over time. The majority of adverse events is stimulation-related, temporary and decreases after adjustment of settings. Future perspectives to improve efficacy and reduce side effects, such as different approaches to increase battery life, transcutaneous stimulation and identification of prognostic factors, should be further investigated.
Main Authors: | , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Academia Brasileira de Neurologia - ABNEURO
2017
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000900657 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S0004-282X2017000900657 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S0004-282X20170009006572017-09-20The role of vagus nerve stimulation in refractory epilepsyOliveira,Tatiana Von Hertwig Fernandes deFrancisco,Alexandre NovickiDemartini Junior,ZeferinoStebel,Sergio Leandro vagus nerve stimulation epilepsy ABSTRACT Vagus nerve stimulation is an adjunctive therapy used to treat patients with refractory epilepsy who are not candidates for resective surgery or had poor results after surgical procedures. Its mechanism of action is not yet fully comprehended but it possibly involves modulation of the locus coeruleus, thalamus and limbic circuit through noradrenergic and serotonergic projections. There is sufficient evidence to support its use in patients with focal epilepsy and other seizure types. However, it should be recognized that improvement is not immediate and increases over time. The majority of adverse events is stimulation-related, temporary and decreases after adjustment of settings. Future perspectives to improve efficacy and reduce side effects, such as different approaches to increase battery life, transcutaneous stimulation and identification of prognostic factors, should be further investigated.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.75 n.9 20172017-09-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000900657en10.1590/0004-282x20170113 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Oliveira,Tatiana Von Hertwig Fernandes de Francisco,Alexandre Novicki Demartini Junior,Zeferino Stebel,Sergio Leandro |
spellingShingle |
Oliveira,Tatiana Von Hertwig Fernandes de Francisco,Alexandre Novicki Demartini Junior,Zeferino Stebel,Sergio Leandro The role of vagus nerve stimulation in refractory epilepsy |
author_facet |
Oliveira,Tatiana Von Hertwig Fernandes de Francisco,Alexandre Novicki Demartini Junior,Zeferino Stebel,Sergio Leandro |
author_sort |
Oliveira,Tatiana Von Hertwig Fernandes de |
title |
The role of vagus nerve stimulation in refractory epilepsy |
title_short |
The role of vagus nerve stimulation in refractory epilepsy |
title_full |
The role of vagus nerve stimulation in refractory epilepsy |
title_fullStr |
The role of vagus nerve stimulation in refractory epilepsy |
title_full_unstemmed |
The role of vagus nerve stimulation in refractory epilepsy |
title_sort |
role of vagus nerve stimulation in refractory epilepsy |
description |
ABSTRACT Vagus nerve stimulation is an adjunctive therapy used to treat patients with refractory epilepsy who are not candidates for resective surgery or had poor results after surgical procedures. Its mechanism of action is not yet fully comprehended but it possibly involves modulation of the locus coeruleus, thalamus and limbic circuit through noradrenergic and serotonergic projections. There is sufficient evidence to support its use in patients with focal epilepsy and other seizure types. However, it should be recognized that improvement is not immediate and increases over time. The majority of adverse events is stimulation-related, temporary and decreases after adjustment of settings. Future perspectives to improve efficacy and reduce side effects, such as different approaches to increase battery life, transcutaneous stimulation and identification of prognostic factors, should be further investigated. |
publisher |
Academia Brasileira de Neurologia - ABNEURO |
publishDate |
2017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000900657 |
work_keys_str_mv |
AT oliveiratatianavonhertwigfernandesde theroleofvagusnervestimulationinrefractoryepilepsy AT franciscoalexandrenovicki theroleofvagusnervestimulationinrefractoryepilepsy AT demartinijuniorzeferino theroleofvagusnervestimulationinrefractoryepilepsy AT stebelsergioleandro theroleofvagusnervestimulationinrefractoryepilepsy AT oliveiratatianavonhertwigfernandesde roleofvagusnervestimulationinrefractoryepilepsy AT franciscoalexandrenovicki roleofvagusnervestimulationinrefractoryepilepsy AT demartinijuniorzeferino roleofvagusnervestimulationinrefractoryepilepsy AT stebelsergioleandro roleofvagusnervestimulationinrefractoryepilepsy |
_version_ |
1756374731688247296 |