Refractory epilepsy in children with brain tumors. The urgency of neurosurgery

ABSTRACT In order to verify indications for surgery, 27 patients with refractory epileptic seizures and brain tumor, aged up to 19 years at the time of surgery, were studied between 1996 and 2013 and followed up for at least one year. The mean interval between the onset of seizures and the diagnosis of the tumor was 3.6 years, and from diagnosis to the surgery, 18 months. The location of the tumor was in the temporal lobe in 16, with ganglioglioma and dysembryoplastic neuroepithelial tumors being the most frequent. Among the patients, 92.5% and 90.4% were seizure-free in the first and fifth year after surgery, respectively. Twelve of 16 children were successful in becoming drug-free, with complete withdrawal by 3.2 years. Surgery proved to be potentially curative and safe in these cases, suggesting that the tumor diagnosis and surgery cannot be postponed.

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Main Authors: Bernardino,Marília Rosa Abtibol, Funayama,Carolina, Hamad,Ana Paula Andrade, Machado,Hélio, Sakamoto,Américo, Thome,Ursula, Terra,Vera Cristina, Santos,Antonio Carlos dos, Serafani,Luciano Nader, Calixto,Nathalia Cunha, Silva,Huria Shalom Monturil de Carvalho
Format: Digital revista
Language:English
Published: Academia Brasileira de Neurologia - ABNEURO 2016
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001201008
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spelling oai:scielo:S0004-282X20160012010082017-04-24Refractory epilepsy in children with brain tumors. The urgency of neurosurgeryBernardino,Marília Rosa AbtibolFunayama,CarolinaHamad,Ana Paula AndradeMachado,HélioSakamoto,AméricoThome,UrsulaTerra,Vera CristinaSantos,Antonio Carlos dosSerafani,Luciano NaderCalixto,Nathalia CunhaSilva,Huria Shalom Monturil de Carvalho brain neoplasms epilepsy child adolescent neurosurgery ABSTRACT In order to verify indications for surgery, 27 patients with refractory epileptic seizures and brain tumor, aged up to 19 years at the time of surgery, were studied between 1996 and 2013 and followed up for at least one year. The mean interval between the onset of seizures and the diagnosis of the tumor was 3.6 years, and from diagnosis to the surgery, 18 months. The location of the tumor was in the temporal lobe in 16, with ganglioglioma and dysembryoplastic neuroepithelial tumors being the most frequent. Among the patients, 92.5% and 90.4% were seizure-free in the first and fifth year after surgery, respectively. Twelve of 16 children were successful in becoming drug-free, with complete withdrawal by 3.2 years. Surgery proved to be potentially curative and safe in these cases, suggesting that the tumor diagnosis and surgery cannot be postponed.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.74 n.12 20162016-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001201008en10.1590/0004-282x20160157
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countrycode BR
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libraryname SciELO
language English
format Digital
author Bernardino,Marília Rosa Abtibol
Funayama,Carolina
Hamad,Ana Paula Andrade
Machado,Hélio
Sakamoto,Américo
Thome,Ursula
Terra,Vera Cristina
Santos,Antonio Carlos dos
Serafani,Luciano Nader
Calixto,Nathalia Cunha
Silva,Huria Shalom Monturil de Carvalho
spellingShingle Bernardino,Marília Rosa Abtibol
Funayama,Carolina
Hamad,Ana Paula Andrade
Machado,Hélio
Sakamoto,Américo
Thome,Ursula
Terra,Vera Cristina
Santos,Antonio Carlos dos
Serafani,Luciano Nader
Calixto,Nathalia Cunha
Silva,Huria Shalom Monturil de Carvalho
Refractory epilepsy in children with brain tumors. The urgency of neurosurgery
author_facet Bernardino,Marília Rosa Abtibol
Funayama,Carolina
Hamad,Ana Paula Andrade
Machado,Hélio
Sakamoto,Américo
Thome,Ursula
Terra,Vera Cristina
Santos,Antonio Carlos dos
Serafani,Luciano Nader
Calixto,Nathalia Cunha
Silva,Huria Shalom Monturil de Carvalho
author_sort Bernardino,Marília Rosa Abtibol
title Refractory epilepsy in children with brain tumors. The urgency of neurosurgery
title_short Refractory epilepsy in children with brain tumors. The urgency of neurosurgery
title_full Refractory epilepsy in children with brain tumors. The urgency of neurosurgery
title_fullStr Refractory epilepsy in children with brain tumors. The urgency of neurosurgery
title_full_unstemmed Refractory epilepsy in children with brain tumors. The urgency of neurosurgery
title_sort refractory epilepsy in children with brain tumors. the urgency of neurosurgery
description ABSTRACT In order to verify indications for surgery, 27 patients with refractory epileptic seizures and brain tumor, aged up to 19 years at the time of surgery, were studied between 1996 and 2013 and followed up for at least one year. The mean interval between the onset of seizures and the diagnosis of the tumor was 3.6 years, and from diagnosis to the surgery, 18 months. The location of the tumor was in the temporal lobe in 16, with ganglioglioma and dysembryoplastic neuroepithelial tumors being the most frequent. Among the patients, 92.5% and 90.4% were seizure-free in the first and fifth year after surgery, respectively. Twelve of 16 children were successful in becoming drug-free, with complete withdrawal by 3.2 years. Surgery proved to be potentially curative and safe in these cases, suggesting that the tumor diagnosis and surgery cannot be postponed.
publisher Academia Brasileira de Neurologia - ABNEURO
publishDate 2016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001201008
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