Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis
OBJECTIVE: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. METHOD: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of São Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. RESULTS: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. CONCLUSION: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life.
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Academia Brasileira de Neurologia - ABNEURO
2010
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oai:scielo:S0004-282X20100004000092010-08-11Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosisGuimarães,Fabio Augusto BronziOliveira-Cardoso,Érika Arantes deMastropietro,Ana PaulaVoltarelli,Júlio CésarSantos,Manoel Antônio dos quality of life multiple sclerosis bone marrow transplantation OBJECTIVE: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. METHOD: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of São Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. RESULTS: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. CONCLUSION: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.68 n.4 20102010-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400009en10.1590/S0004-282X2010000400009 |
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Guimarães,Fabio Augusto Bronzi Oliveira-Cardoso,Érika Arantes de Mastropietro,Ana Paula Voltarelli,Júlio César Santos,Manoel Antônio dos |
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Guimarães,Fabio Augusto Bronzi Oliveira-Cardoso,Érika Arantes de Mastropietro,Ana Paula Voltarelli,Júlio César Santos,Manoel Antônio dos Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
author_facet |
Guimarães,Fabio Augusto Bronzi Oliveira-Cardoso,Érika Arantes de Mastropietro,Ana Paula Voltarelli,Júlio César Santos,Manoel Antônio dos |
author_sort |
Guimarães,Fabio Augusto Bronzi |
title |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
title_short |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
title_full |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
title_fullStr |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
title_full_unstemmed |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
title_sort |
impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
description |
OBJECTIVE: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. METHOD: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of São Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. RESULTS: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. CONCLUSION: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life. |
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Academia Brasileira de Neurologia - ABNEURO |
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2010 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400009 |
work_keys_str_mv |
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