Toxic myopathies: muscle biopsy features

Toxic myopathies: muscle biopsy features

Several drugs and toxic substances can cause muscular abnormalities and are frequent causes of acquired myopathies. We present a series of 32 patients, predominance of young adult patients, diagnosed with toxic myopathy. The most common substances inducing myopathy were corticosteroids (56.2%) followed by the propoxyphene, neuroleptics, zidovudine and drug-induced hypokalemia. The investigation showed normal serum creatine kinase levels in 65.4%, myopathic pattern of the needle electromyography in 40% and the more frequent histological diagnosis of the muscle biopsy was type 2 fiber atrophy (59.3%). Clinical features, etiology, course of the disease, serum levels of muscular enzymes, electromyographic features and, especially, muscle biopsy features are discussed.

Saved in:
Bibliographic Details
Main Authors: Scola,Rosana Herminia, Pereira,Eduardo Rafael, Lorenzoni,Paulo José, Werneck,Lineu César
Format: Digital revista
Language:English
Published: Academia Brasileira de Neurologia - ABNEURO 2007
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100018
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S0004-282X2007000100018
record_format ojs
spelling oai:scielo:S0004-282X20070001000182007-03-21Toxic myopathies: muscle biopsy featuresScola,Rosana HerminiaPereira,Eduardo RafaelLorenzoni,Paulo JoséWerneck,Lineu César myopathy drug iatrogenic myopathy toxic myopathy muscle biopsy Several drugs and toxic substances can cause muscular abnormalities and are frequent causes of acquired myopathies. We present a series of 32 patients, predominance of young adult patients, diagnosed with toxic myopathy. The most common substances inducing myopathy were corticosteroids (56.2%) followed by the propoxyphene, neuroleptics, zidovudine and drug-induced hypokalemia. The investigation showed normal serum creatine kinase levels in 65.4%, myopathic pattern of the needle electromyography in 40% and the more frequent histological diagnosis of the muscle biopsy was type 2 fiber atrophy (59.3%). Clinical features, etiology, course of the disease, serum levels of muscular enzymes, electromyographic features and, especially, muscle biopsy features are discussed.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.65 n.1 20072007-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100018en10.1590/S0004-282X2007000100018
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Scola,Rosana Herminia
Pereira,Eduardo Rafael
Lorenzoni,Paulo José
Werneck,Lineu César
spellingShingle Scola,Rosana Herminia
Pereira,Eduardo Rafael
Lorenzoni,Paulo José
Werneck,Lineu César
Toxic myopathies: muscle biopsy features
author_facet Scola,Rosana Herminia
Pereira,Eduardo Rafael
Lorenzoni,Paulo José
Werneck,Lineu César
author_sort Scola,Rosana Herminia
title Toxic myopathies: muscle biopsy features
title_short Toxic myopathies: muscle biopsy features
title_full Toxic myopathies: muscle biopsy features
title_fullStr Toxic myopathies: muscle biopsy features
title_full_unstemmed Toxic myopathies: muscle biopsy features
title_sort toxic myopathies: muscle biopsy features
description Several drugs and toxic substances can cause muscular abnormalities and are frequent causes of acquired myopathies. We present a series of 32 patients, predominance of young adult patients, diagnosed with toxic myopathy. The most common substances inducing myopathy were corticosteroids (56.2%) followed by the propoxyphene, neuroleptics, zidovudine and drug-induced hypokalemia. The investigation showed normal serum creatine kinase levels in 65.4%, myopathic pattern of the needle electromyography in 40% and the more frequent histological diagnosis of the muscle biopsy was type 2 fiber atrophy (59.3%). Clinical features, etiology, course of the disease, serum levels of muscular enzymes, electromyographic features and, especially, muscle biopsy features are discussed.
publisher Academia Brasileira de Neurologia - ABNEURO
publishDate 2007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000100018
work_keys_str_mv AT scolarosanaherminia toxicmyopathiesmusclebiopsyfeatures
AT pereiraeduardorafael toxicmyopathiesmusclebiopsyfeatures
AT lorenzonipaulojose toxicmyopathiesmusclebiopsyfeatures
AT wernecklineucesar toxicmyopathiesmusclebiopsyfeatures
_version_ 1756374360797478912

Similar Items