Primary progressive aphasia: analisys of 16 cases
Primary progressive aphasia (PPA) is an intriguing syndrome, showing some peculiar aspects that differentiate it from classical aphasic pictures caused by focal cerebral lesions or dementia. The slow and progressive deterioration of language occurring in these cases provides an interesting model to better understand the mechanisms involved in the linguistic process. We describe clinical and neuroimaging aspects found in 16 cases of PPA. Our patients underwent language and neuropsychological evaluation, magnetic resonance imaging (MRI) and single photon emission computerized tomography (SPECT). We observed a clear distinction in oral expression patterns; patients were classified as fluent and nonfluent. Anomia was the earliest and most evident symptom in both groups. Neuroimaging pointed to SPECT as a valuable instrument in guiding the differential diagnosis, as well as in making useful clinical and anatomical correlations. This report and a comparison to literature are an attempt to contribute to a better understanding of PPA.
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Academia Brasileira de Neurologia - ABNEURO
2001
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oai:scielo:S0004-282X20010004000062001-10-04Primary progressive aphasia: analisys of 16 casesRadanovic,MárciaSenaha,Mirna Lie HosogiMansur,Letícia LessaNitrini,RicardoBahia,Valéria SantoroCarthery,Maria TeresaAires,Flávia Nóbrega FreireMathias,Sandra ChristinaCaramelli,Paulo primary progressive aphasia focal cortical degeneration cerebral perfusion neuroimaging Primary progressive aphasia (PPA) is an intriguing syndrome, showing some peculiar aspects that differentiate it from classical aphasic pictures caused by focal cerebral lesions or dementia. The slow and progressive deterioration of language occurring in these cases provides an interesting model to better understand the mechanisms involved in the linguistic process. We describe clinical and neuroimaging aspects found in 16 cases of PPA. Our patients underwent language and neuropsychological evaluation, magnetic resonance imaging (MRI) and single photon emission computerized tomography (SPECT). We observed a clear distinction in oral expression patterns; patients were classified as fluent and nonfluent. Anomia was the earliest and most evident symptom in both groups. Neuroimaging pointed to SPECT as a valuable instrument in guiding the differential diagnosis, as well as in making useful clinical and anatomical correlations. This report and a comparison to literature are an attempt to contribute to a better understanding of PPA.info:eu-repo/semantics/openAccessAcademia Brasileira de Neurologia - ABNEUROArquivos de Neuro-Psiquiatria v.59 n.3A 20012001-09-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000400006en10.1590/S0004-282X2001000400006 |
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Radanovic,Márcia Senaha,Mirna Lie Hosogi Mansur,Letícia Lessa Nitrini,Ricardo Bahia,Valéria Santoro Carthery,Maria Teresa Aires,Flávia Nóbrega Freire Mathias,Sandra Christina Caramelli,Paulo |
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Radanovic,Márcia Senaha,Mirna Lie Hosogi Mansur,Letícia Lessa Nitrini,Ricardo Bahia,Valéria Santoro Carthery,Maria Teresa Aires,Flávia Nóbrega Freire Mathias,Sandra Christina Caramelli,Paulo Primary progressive aphasia: analisys of 16 cases |
author_facet |
Radanovic,Márcia Senaha,Mirna Lie Hosogi Mansur,Letícia Lessa Nitrini,Ricardo Bahia,Valéria Santoro Carthery,Maria Teresa Aires,Flávia Nóbrega Freire Mathias,Sandra Christina Caramelli,Paulo |
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Radanovic,Márcia |
title |
Primary progressive aphasia: analisys of 16 cases |
title_short |
Primary progressive aphasia: analisys of 16 cases |
title_full |
Primary progressive aphasia: analisys of 16 cases |
title_fullStr |
Primary progressive aphasia: analisys of 16 cases |
title_full_unstemmed |
Primary progressive aphasia: analisys of 16 cases |
title_sort |
primary progressive aphasia: analisys of 16 cases |
description |
Primary progressive aphasia (PPA) is an intriguing syndrome, showing some peculiar aspects that differentiate it from classical aphasic pictures caused by focal cerebral lesions or dementia. The slow and progressive deterioration of language occurring in these cases provides an interesting model to better understand the mechanisms involved in the linguistic process. We describe clinical and neuroimaging aspects found in 16 cases of PPA. Our patients underwent language and neuropsychological evaluation, magnetic resonance imaging (MRI) and single photon emission computerized tomography (SPECT). We observed a clear distinction in oral expression patterns; patients were classified as fluent and nonfluent. Anomia was the earliest and most evident symptom in both groups. Neuroimaging pointed to SPECT as a valuable instrument in guiding the differential diagnosis, as well as in making useful clinical and anatomical correlations. This report and a comparison to literature are an attempt to contribute to a better understanding of PPA. |
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Academia Brasileira de Neurologia - ABNEURO |
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2001 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000400006 |
work_keys_str_mv |
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