Subclinical Diabetes
ABSTRACT Type 2 diabetes mellitus (T2DM) is increasing in prevalence worldwide, and those non-diagnosed or misdiagnosed comprise a significant group compared to those diagnosed. Accumulated scientific evidence indicate that the current diagnostic markers (fasting glycemia, 2h glycemia after an oral glucose load and HbA1c) are indeed late diagnostic criteria when considering the incidence of diabetes-related complications and comorbidities, which are also at high risk in some groups among normoglycemic individuals. Additionally, the earlier identification of future risk of diabetes is desirable since it would allow better adherence to preventive actions such as lifestyle intervention, ultimately avoiding complications and minimizing the economic impact/burden on health care expenses. Insulin resistance and hyperhormonemia (insulin, amylin, glucagon) are non-disputable hallmarks of T2DM, which already takes place among these normoglycemic, otherwise health subjects, characterizing a state of subclinical diabetes. Insulin resistance and hyperinsulinemia can be computed from fasting plasma insulin as an independent variable in normoglycemia. An overview of the current diagnostic criteria, disease onset, complications, comorbidities and perspectives on lifestyle interventions are presented. A proposal for early detection of subclinical diabetes from routine evaluation of fasting plasma insulin, which is affordable and robust and thus applicable for the general population, is further suggested.
Autor principal: | LIMA,LUÍS M.T.R. |
---|---|
Formato: | Digital revista |
Idioma: | English |
Publicado em: |
Academia Brasileira de Ciências
2017
|
Acesso em linha: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200591 |
Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|
Registros relacionados
-
Ankle-brachial index and subclinical atherosclerosis in type 1 diabetes
por: Lima,Alexandra Corrêa Gervazoni Balbuena de, et al.
Publicado em: (2021) -
Subclinical carotid vascular disease and risk factors for atherosclerosis in type 1 and type 2 diabetes
por: Rocha,Viviane Z., et al.
Publicado em: (2017) -
New Method Improves the Evaluation of Subclinical Left Ventricular Dysfunction in Type 2 Diabetes Mellitus
por: Askin,Lutfu, et al.
Publicado em: (2019) -
Subclinical Cushing's syndrome
por: Terzolo,Massimo, et al.
Publicado em: (2007) -
Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus
por: Kupfer,Rosane, et al.
Publicado em: (2017)