New carbohydrazide derivatives of 1H-pyrazolo[3,4-b]pyridine and trypanocidal activity

ABSTRACT This paper reports the in vitro trypanocidal activity evaluation of new carbohydrazide derivatives from 3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine, substituted at C-6 position by phenyl, methyl or trifluoromethyl group. These compounds were evaluated in order to identify the antiparasitic profile against trypomastigote and amastigote forms of Trypanosoma cruzi. The 4-carbohydrazide derivatives presented different profiles of activity. In the investigation of the chemical structure influence in the trypanocidal activity, the results indicated there are large lipophilicity and volume differences among these derivatives. The complementarities of their stereoelectronic and physical-chemical aspects seem to be relevant for the biological activity against T. cruzi.

Bibliographic Details

Main Authors:	SALVADOR,RAQUEL R.S., BELLO,MURILO L., BARRETO,IGOR R.L., VERA,MARIA A.F., MURI,ESTELA M.F., ALBUQUERQUE,SÉRGIO DE, DIAS,LUIZA R.S.
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Ciências 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602341
Tags:	Add Tag No Tags, Be the first to tag this record!