Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern Brazil

Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern Brazil

Natural antioxidants found in marine macroalgae are bioactive compounds known to play an important role in the prevention of diseases associated with aging cells protecting them against the oxidative damage. The purpose of this study was to evaluate the antioxidant and cytotoxic activity of ethanolic extracts of two species of red seaweeds, Amansia multifida and Meristiella echinocarpa. In vitro antioxidant activity was determined by DPPH radical scavenging assay, ferric-reducing antioxidant power (FRAP) assay, ferrous ion chelating (FIC) assay, β-carotene bleaching (BCB) assay and total phenolic content (TPC) quantification. Cytotoxicity was evaluated with the brine shrimp Artemia sp. lethality test. The TPC values observed in the present study indicated that both species A. multifida and M. echinocarpa are rich in phenolic compounds, reaching values of 45.40 and 28.46 mg gallic acid equivalent (GAE) g−1 of ethanolic extract, respectively. DPPH radical scavenging and ferrous ion chelating showed values of 60% and 17%, respectively. Both seaweed extracts inhibited β-carotene oxidation by approximately 40%. None of the algal extracts were potentially cytotoxic. The results have showed that extracts of both species of marine red algae exhibit antioxidant potential and low toxicity. They are sources of natural antioxidant compounds.

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Main Authors: ALENCAR,DANIEL B. DE, SILVA,SUZETE R. DA, PIRES-CAVALCANTE,KELMA M.S., LIMA,REBECA L. DE, PEREIRA JÚNIOR,FRANCISCO N., SOUSA,MÁRCIA B. DE, VIANA,FRANCISCO A., NAGANO,CELSO S., NASCIMENTO,KYRIA S. DO, CAVADA,BENILDO S., SAMPAIO,ALEXANDRE H., SAKER-SAMPAIO,SILVANA
Format: Digital revista
Language:English
Published: Academia Brasileira de Ciências 2014
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000100251
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spelling oai:scielo:S0001-376520140001002512015-11-10Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern BrazilALENCAR,DANIEL B. DESILVA,SUZETE R. DAPIRES-CAVALCANTE,KELMA M.S.LIMA,REBECA L. DEPEREIRA JÚNIOR,FRANCISCO N.SOUSA,MÁRCIA B. DEVIANA,FRANCISCO A.NAGANO,CELSO S.NASCIMENTO,KYRIA S. DOCAVADA,BENILDO S.SAMPAIO,ALEXANDRE H.SAKER-SAMPAIO,SILVANA antioxidant bioactive compounds cytotoxic phenolic compounds Rhodophyta Natural antioxidants found in marine macroalgae are bioactive compounds known to play an important role in the prevention of diseases associated with aging cells protecting them against the oxidative damage. The purpose of this study was to evaluate the antioxidant and cytotoxic activity of ethanolic extracts of two species of red seaweeds, Amansia multifida and Meristiella echinocarpa. In vitro antioxidant activity was determined by DPPH radical scavenging assay, ferric-reducing antioxidant power (FRAP) assay, ferrous ion chelating (FIC) assay, β-carotene bleaching (BCB) assay and total phenolic content (TPC) quantification. Cytotoxicity was evaluated with the brine shrimp Artemia sp. lethality test. The TPC values observed in the present study indicated that both species A. multifida and M. echinocarpa are rich in phenolic compounds, reaching values of 45.40 and 28.46 mg gallic acid equivalent (GAE) g−1 of ethanolic extract, respectively. DPPH radical scavenging and ferrous ion chelating showed values of 60% and 17%, respectively. Both seaweed extracts inhibited β-carotene oxidation by approximately 40%. None of the algal extracts were potentially cytotoxic. The results have showed that extracts of both species of marine red algae exhibit antioxidant potential and low toxicity. They are sources of natural antioxidant compounds.info:eu-repo/semantics/openAccessAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências v.86 n.1 20142014-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000100251en10.1590/0001-37652014116312
institution SCIELO
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country Brasil
countrycode BR
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libraryname SciELO
language English
format Digital
author ALENCAR,DANIEL B. DE
SILVA,SUZETE R. DA
PIRES-CAVALCANTE,KELMA M.S.
LIMA,REBECA L. DE
PEREIRA JÚNIOR,FRANCISCO N.
SOUSA,MÁRCIA B. DE
VIANA,FRANCISCO A.
NAGANO,CELSO S.
NASCIMENTO,KYRIA S. DO
CAVADA,BENILDO S.
SAMPAIO,ALEXANDRE H.
SAKER-SAMPAIO,SILVANA
spellingShingle ALENCAR,DANIEL B. DE
SILVA,SUZETE R. DA
PIRES-CAVALCANTE,KELMA M.S.
LIMA,REBECA L. DE
PEREIRA JÚNIOR,FRANCISCO N.
SOUSA,MÁRCIA B. DE
VIANA,FRANCISCO A.
NAGANO,CELSO S.
NASCIMENTO,KYRIA S. DO
CAVADA,BENILDO S.
SAMPAIO,ALEXANDRE H.
SAKER-SAMPAIO,SILVANA
Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern Brazil
author_facet ALENCAR,DANIEL B. DE
SILVA,SUZETE R. DA
PIRES-CAVALCANTE,KELMA M.S.
LIMA,REBECA L. DE
PEREIRA JÚNIOR,FRANCISCO N.
SOUSA,MÁRCIA B. DE
VIANA,FRANCISCO A.
NAGANO,CELSO S.
NASCIMENTO,KYRIA S. DO
CAVADA,BENILDO S.
SAMPAIO,ALEXANDRE H.
SAKER-SAMPAIO,SILVANA
author_sort ALENCAR,DANIEL B. DE
title Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern Brazil
title_short Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern Brazil
title_full Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern Brazil
title_fullStr Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern Brazil
title_full_unstemmed Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern Brazil
title_sort antioxidant potential and cytotoxic activity of two red seaweed species, amansia multifida and meristiella echinocarpa, from the coast of northeastern brazil
description Natural antioxidants found in marine macroalgae are bioactive compounds known to play an important role in the prevention of diseases associated with aging cells protecting them against the oxidative damage. The purpose of this study was to evaluate the antioxidant and cytotoxic activity of ethanolic extracts of two species of red seaweeds, Amansia multifida and Meristiella echinocarpa. In vitro antioxidant activity was determined by DPPH radical scavenging assay, ferric-reducing antioxidant power (FRAP) assay, ferrous ion chelating (FIC) assay, β-carotene bleaching (BCB) assay and total phenolic content (TPC) quantification. Cytotoxicity was evaluated with the brine shrimp Artemia sp. lethality test. The TPC values observed in the present study indicated that both species A. multifida and M. echinocarpa are rich in phenolic compounds, reaching values of 45.40 and 28.46 mg gallic acid equivalent (GAE) g−1 of ethanolic extract, respectively. DPPH radical scavenging and ferrous ion chelating showed values of 60% and 17%, respectively. Both seaweed extracts inhibited β-carotene oxidation by approximately 40%. None of the algal extracts were potentially cytotoxic. The results have showed that extracts of both species of marine red algae exhibit antioxidant potential and low toxicity. They are sources of natural antioxidant compounds.
publisher Academia Brasileira de Ciências
publishDate 2014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000100251
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