Voltammetric characteristics of miconazole and its cathodic stripping voltammetric determination

Miconazole is reduced at mercury electrode above pH 6 involving organometallic compound formation, responsible for an anomalous polarographic behavior. The electrodic process presents a large contribution of the adsorption effects. The drug can be determined by cathodic stripping voltammetry from 8.0 x 10-8 to 1, 5 x 10-6 molL-1 in Britton-Robinson buffer pH 8.0, when pre-accumulated for 30s at an accumulation potential of 0V. A relative standard deviation of 3.8% was obtained for ten measurements of 1.0 x 10-7 molL-1 miconazole in B-R buffer pH 8.0 and a limit detection of 1, 7 x 10-8 molL-1 was determined using 60s of deposition time and scan rate of 100 mVs-1. The proposed method is simple, precise and it was applied successfully for the determination of the miconazole in pure form and in commercial formulations, showing mean recoveries of 99.7-98.4%.

Bibliographic Details

Main Authors:	PEREIRA,FRANCISCO C., STRADIOTTO,NELSON R., ZANONI,MARIA VALNICE B.
Format:	Digital revista
Language:	English
Published:	Academia Brasileira de Ciências 2002
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000300005
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