Identification of a major 72 kilodalton surface antigen in twelve isolates of Leishmania braziliensis braziliensis

The study of the surface antigens of Leishmania braziliensis braziliensis revealed a great homogeneity among ten strains isolated from Bolivia and two reference strains from Brazil and Belize. A 72 kDa major protein, present in all L. b. braziliensis strains, was recognized by both cutaneous and mucocutaneous human sera, but was not recognized by Kala-azar and chagasic sera. No cross-reactive antigens were found among strains of Leishmania braziliensis guyanensis, Leishmania braziliensis panamensis, Leishmania mexicana amazonensis and Leishmania donovani chagasi testing these strains with hamster and human anti-L. b. bra ziliensis sera. Moreover, these strains possessed major antigens with molecular weights different from those of L. b. braziliensis strains. A microheterogeneity of L. b. braziliercis surface antigens was detected for the high molecular weight antigens and seemed to be related to the isoenzymic microheterogeneity.

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Detalhes bibliográficos
Principais autores: Legrand, Dominique, Desjeux, Philippe, Le Pont, François, Brenière, Simone Frédérique, Lemesre, Jean-Loup, Santoro, Ferrucio, Capron, André
Formato: Atigo biblioteca
Idioma:English
Publicado em: Molecular and Biochemical Parsitology 1987
Assuntos:LEISHMANIA BRAZILIENSIS BRAZILIENSIS, YODACIÓN DE LA SUPERFICIE CELULAR, INMUNOPRECIPITACIÓN, ANTÍGENO DE SUPERFICIE,
Acesso em linha:http://repositorio.umsa.bo/xmlui/handle/123456789/10604
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