Identification of a major 72 kilodalton surface antigen in twelve isolates of Leishmania braziliensis braziliensis

Identification of a major 72 kilodalton surface antigen in twelve isolates of Leishmania braziliensis braziliensis

The study of the surface antigens of Leishmania braziliensis braziliensis revealed a great homogeneity among ten strains isolated from Bolivia and two reference strains from Brazil and Belize. A 72 kDa major protein, present in all L. b. braziliensis strains, was recognized by both cutaneous and mucocutaneous human sera, but was not recognized by Kala-azar and chagasic sera. No cross-reactive antigens were found among strains of Leishmania braziliensis guyanensis, Leishmania braziliensis panamensis, Leishmania mexicana amazonensis and Leishmania donovani chagasi testing these strains with hamster and human anti-L. b. bra ziliensis sera. Moreover, these strains possessed major antigens with molecular weights different from those of L. b. braziliensis strains. A microheterogeneity of L. b. braziliercis surface antigens was detected for the high molecular weight antigens and seemed to be related to the isoenzymic microheterogeneity.

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Autores principales: Legrand, Dominique, Desjeux, Philippe, Le Pont, François, Brenière, Simone Frédérique, Lemesre, Jean-Loup, Santoro, Ferrucio, Capron, André
Formato: Artículo biblioteca
Idioma:English
Publicado: Molecular and Biochemical Parsitology 1987
Materias:LEISHMANIA BRAZILIENSIS BRAZILIENSIS, YODACIÓN DE LA SUPERFICIE CELULAR, INMUNOPRECIPITACIÓN, ANTÍGENO DE SUPERFICIE,
Acceso en línea:http://repositorio.umsa.bo/xmlui/handle/123456789/10604
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spelling oai:localhost:8080:123456789-106042020-09-10T15:28:53Z Identification of a major 72 kilodalton surface antigen in twelve isolates of Leishmania braziliensis braziliensis Legrand, Dominique Desjeux, Philippe Le Pont, François Brenière, Simone Frédérique Lemesre, Jean-Loup Santoro, Ferrucio Capron, André LEISHMANIA BRAZILIENSIS BRAZILIENSIS YODACIÓN DE LA SUPERFICIE CELULAR INMUNOPRECIPITACIÓN ANTÍGENO DE SUPERFICIE The study of the surface antigens of Leishmania braziliensis braziliensis revealed a great homogeneity among ten strains isolated from Bolivia and two reference strains from Brazil and Belize. A 72 kDa major protein, present in all L. b. braziliensis strains, was recognized by both cutaneous and mucocutaneous human sera, but was not recognized by Kala-azar and chagasic sera. No cross-reactive antigens were found among strains of Leishmania braziliensis guyanensis, Leishmania braziliensis panamensis, Leishmania mexicana amazonensis and Leishmania donovani chagasi testing these strains with hamster and human anti-L. b. bra ziliensis sera. Moreover, these strains possessed major antigens with molecular weights different from those of L. b. braziliensis strains. A microheterogeneity of L. b. braziliercis surface antigens was detected for the high molecular weight antigens and seemed to be related to the isoenzymic microheterogeneity. 2017-06-06T18:06:51Z 2017-06-06T18:06:51Z 1987 Article http://repositorio.umsa.bo/xmlui/handle/123456789/10604 en application/pdf Molecular and Biochemical Parsitology
institution UMSA BO
collection DSpace
country Bolivia
countrycode BO
component Bibliográfico
access En linea
databasecode dig-umsa-bo
tag biblioteca
region America del Sur
libraryname Sistema de Unidades de Información de UMSA
language English
topic LEISHMANIA BRAZILIENSIS BRAZILIENSIS
YODACIÓN DE LA SUPERFICIE CELULAR
INMUNOPRECIPITACIÓN
ANTÍGENO DE SUPERFICIE
LEISHMANIA BRAZILIENSIS BRAZILIENSIS
YODACIÓN DE LA SUPERFICIE CELULAR
INMUNOPRECIPITACIÓN
ANTÍGENO DE SUPERFICIE
spellingShingle LEISHMANIA BRAZILIENSIS BRAZILIENSIS
YODACIÓN DE LA SUPERFICIE CELULAR
INMUNOPRECIPITACIÓN
ANTÍGENO DE SUPERFICIE
LEISHMANIA BRAZILIENSIS BRAZILIENSIS
YODACIÓN DE LA SUPERFICIE CELULAR
INMUNOPRECIPITACIÓN
ANTÍGENO DE SUPERFICIE
Legrand, Dominique
Desjeux, Philippe
Le Pont, François
Brenière, Simone Frédérique
Lemesre, Jean-Loup
Santoro, Ferrucio
Capron, André
Identification of a major 72 kilodalton surface antigen in twelve isolates of Leishmania braziliensis braziliensis
description The study of the surface antigens of Leishmania braziliensis braziliensis revealed a great homogeneity among ten strains isolated from Bolivia and two reference strains from Brazil and Belize. A 72 kDa major protein, present in all L. b. braziliensis strains, was recognized by both cutaneous and mucocutaneous human sera, but was not recognized by Kala-azar and chagasic sera. No cross-reactive antigens were found among strains of Leishmania braziliensis guyanensis, Leishmania braziliensis panamensis, Leishmania mexicana amazonensis and Leishmania donovani chagasi testing these strains with hamster and human anti-L. b. bra ziliensis sera. Moreover, these strains possessed major antigens with molecular weights different from those of L. b. braziliensis strains. A microheterogeneity of L. b. braziliercis surface antigens was detected for the high molecular weight antigens and seemed to be related to the isoenzymic microheterogeneity.
format Article
topic_facet LEISHMANIA BRAZILIENSIS BRAZILIENSIS
YODACIÓN DE LA SUPERFICIE CELULAR
INMUNOPRECIPITACIÓN
ANTÍGENO DE SUPERFICIE
author Legrand, Dominique
Desjeux, Philippe
Le Pont, François
Brenière, Simone Frédérique
Lemesre, Jean-Loup
Santoro, Ferrucio
Capron, André
author_facet Legrand, Dominique
Desjeux, Philippe
Le Pont, François
Brenière, Simone Frédérique
Lemesre, Jean-Loup
Santoro, Ferrucio
Capron, André
author_sort Legrand, Dominique
title Identification of a major 72 kilodalton surface antigen in twelve isolates of Leishmania braziliensis braziliensis
title_short Identification of a major 72 kilodalton surface antigen in twelve isolates of Leishmania braziliensis braziliensis
title_full Identification of a major 72 kilodalton surface antigen in twelve isolates of Leishmania braziliensis braziliensis
title_fullStr Identification of a major 72 kilodalton surface antigen in twelve isolates of Leishmania braziliensis braziliensis
title_full_unstemmed Identification of a major 72 kilodalton surface antigen in twelve isolates of Leishmania braziliensis braziliensis
title_sort identification of a major 72 kilodalton surface antigen in twelve isolates of leishmania braziliensis braziliensis
publisher Molecular and Biochemical Parsitology
publishDate 1987
url http://repositorio.umsa.bo/xmlui/handle/123456789/10604
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